Abstract:
:Transgenic mice were produced by the microinjection of the cDNA of human alpha-fetoprotein (AFP) under control of the enhancer/promoter of the human beta-actin gene. Among the 4 mouse lines where the transgene were stable transmitted to the progeny, 3 produced human AFP. The expression was not developmental stage-specific nor tissue-specific as predicted from the properties of enhancer/promoter. The serum human AFP levels of adult mice were 30-600-fold higher than those of mouse AFP. These mice could be useful for the studies of possible biological functions of AFP during development as well as in malignancies.
journal_name
Biochem Biophys Res Communjournal_title
Biochemical and biophysical research communicationsauthors
Yamashita T,Kasai N,Miyoshi I,Sasaki N,Maki K,Sakai M,Nishi S,Namioka Sdoi
10.1006/bbrc.1993.1276subject
Has Abstractpub_date
1993-03-15 00:00:00pages
715-20issue
2eissn
0006-291Xissn
1090-2104pii
S0006-291X(83)71276-3journal_volume
191pub_type
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