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Cleavage-induced termination in U2 snRNA gene expression.

Abstract：

:The maturation of many small nuclear RNAs is dependent on RNase III-like endonuclease mediated cleavage, which generates a loading site for the exosome complex that trims the precursor at its 3' end. Using a temperature sensitive Pac1 nuclease, here we show that the endonuclease cleavage is equally important in terminating the transcription of the U2 snRNA in Schizosaccharomyces pombe. Using a temperature sensitive Dhp1p 5'-->3' exonuclease, we demonstrate that it also is an essential component of the termination pathway. Taken together the results support a "reversed torpedoes" model for the termination and maturation of the U2 snRNA; the Pac1 endonuclease cleavage provides entry sites for the 3' and 5' exonuclease activities, leading to RNA maturation in one direction and transcript termination in the other.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Nabavi S,Nazar RN

doi

10.1016/j.bbrc.2010.02.023

subject

Has Abstract

pub_date

2010-03-12 00:00:00

pages

461-5

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(10)00234-2

journal_volume

393

pub_type

杂志文章

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