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Inhibitors of sterol synthesis. Dietary administration of 5 alpha-cholest-8(14)-en-3 beta-ol-15-one inhibits the intestinal absorption of cholesterol in lymph-cannulated rats.

Abstract：

:The effect of 5 alpha-cholest-8(14)-en-3 beta-ol-15-one, a potent inhibitor of cholesterol synthesis with marked hypocholesterolemic activity, on the intestinal absorption of exogenous cholesterol has been studied in lymph-cannulated rats. Administration of the 15-ketosterol at a level of 0.05% in a rat chow diet for 10 days was associated with a marked decrease (-64%) in the absorption of cholesterol.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Schroepfer GJ Jr,Christophe A,Needleman DH,Kisic A,Sherrill BC

doi

10.1016/0006-291x(87)90747-9

subject

Has Abstract

pub_date

1987-08-14 00:00:00

pages

1003-8

issue

3

eissn

0006-291X

issn

1090-2104

pii

0006-291X(87)90747-9

journal_volume

146

pub_type

杂志文章

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