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Increase in junctional conductance caused by isoproterenol in heart cell pairs is suppressed by cAMP-dependent protein-kinase inhibitor.

Abstract：

:The influence of isoproterenol (10(-6) M) on junctional conductance of cell pairs isolated from adult rat ventricle was investigated using two separated voltage-clamp circuits. The drug increased the junctional conductance by 40% (S.E. +/- 11%) (n = 10) within 20 sec. In experiments in which an inhibitor of cAMP dependent-protein Kinase was introduced into the cells the effect of isoproterenol on junctional conductance was totally suppressed. These results support the view that cAMP involved in the fast-modulation of junctional conductance in heart and that the activation of a protein Kinase is needed for the effect of the nucleotide on junctional conductance.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

De Mello WC

doi

10.1016/0006-291x(88)90169-6

subject

Has Abstract

pub_date

1988-07-29 00:00:00

pages

509-14

issue

2

eissn

0006-291X

issn

1090-2104

pii

0006-291X(88)90169-6

journal_volume

154

pub_type

杂志文章

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