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DNA repair in lymphocytes from humans and rats with chronic iron overload.

Abstract：

:A marked reduction of the proliferative capability after a mitogenic stimulus and a dramatic decrease of the capacity to repair DNA damages were found in lymphocytes from iron overloaded rats. These immunological parameters were not significantly different from controls in peripheral blood lymphocytes from patients with primary iron overload: hereditary hemochromatosis and porphyria cutanea tarda. This discrepancy could be due to the accelerated modality of iron overload in the rat model and to the fact that rat lymphocytes were obtained from an highly iron repleted microenvironment (i.e. spleen). Our data indicate that iron overload can affect the structure and/or the function of cellular DNA thus offering new insights on the close association of iron overload conditions and cancer.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Pietrangelo A,Cossarizza A,Monti D,Ventura E,Franceschi C

doi

10.1016/0006-291x(88)90196-9

subject

Has Abstract

pub_date

1988-07-29 00:00:00

pages

698-704

issue

2

eissn

0006-291X

issn

1090-2104

pii

0006-291X(88)90196-9

journal_volume

154

pub_type

杂志文章

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