The N-terminal sequence of murine PRMT5 variant 2 is required for Hsp70 interaction and CHIP ligase-mediated degradation.

abstract：:The effects of the serine/threonine phosphatase inhibitors calyculin A, okadaic acid and the calmodulin antagonist W-7 on amylase secretion were studied in pancreatic acini. Calyculin A and okadaic acid dose-dependently inhibited amylase secretion to basal levels when stimulated with the intracellularly acting secreta...

journal_title：Biochemical and biophysical research communications

authors： Meyer-Alber A,Fetz I,Waschulewski IH,Höcker M,Fölsch UR,Schmidt WE

更新日期：1994-06-30 00:00:00

abstract：:N-Glycosylation has been shown to affect the rate of glycoprotein transport through the secretory pathway. In order to identify the critical components in the N-glycosylation pathway that directly influence protein secretion, we have studied the effects of downregulation of the first gene in the dolichol pathway, ALG7...

journal_title：Biochemical and biophysical research communications

authors： Kukuruzinska MA,Apekin V,Lamkin MS,Hiltz A,Rodriguez A,Lin CC,Paz MA,Oppenheim FG

更新日期：1994-02-15 00:00:00

abstract：:Botulinum neurotoxin (NT) serotype A isolated from cells from young cultures (approximately 8 h) of Clostridium botulinum type A is a approximately 150 kDa single chain protein. Supernatant from older cultures (96 h) yields approximately 150 kDa dichain NT composed approximately 50 and approximately 100 kDa subunits, ...

journal_title：Biochemical and biophysical research communications

authors： Dekleva ML,DasGupta BR

更新日期：1989-07-31 00:00:00

abstract：:Membrane protein solubilized by octyl-beta-D-glucopyranoside in the presence of dispersed phospholipid was incubated with bath-sonicated liposomes and additional detergent. The proteoliposomes formed on dilution showed transport and exchange properties consistent with a reconstitution of phosphate:sugar 6-phosphate an...

journal_title：Biochemical and biophysical research communications

authors： Ambudkar SV,Maloney PC

更新日期：1985-06-14 00:00:00

abstract：:Copper ions reportedly bind to the cellular prion (PrPC) and induce PrP proteinase K (PK) resistant from (PrPres). PrPC also plays a role in response to oxidative stress. By using purified human PrP23-98 containing octarepeats, we have found that Cu(II) induces PrPres determined by Western blots and atomic force micro...

journal_title：Biochemical and biophysical research communications

authors： Lu B,Zhao L,Qin K

更新日期：2018-05-15 00:00:00

abstract：:The cytolytic mechanism of cholesterol-dependent cytolysins (CDCs) requires the presence of cholesterol in the target cell membrane. Membrane cholesterol was thought to serve as the common receptor for these toxins, but not all CDCs require cholesterol for binding. One member of this toxin family, pneumolysin (PLY) is...

journal_title：Biochemical and biophysical research communications

authors： Lim JE,Park SA,Bong SM,Chi YM,Lee KS

更新日期：2013-01-11 00:00:00

abstract：:Due to the redundancy of the genetic code there exist six mRNA codons for arginine and several tRNA(Arg) isoacceptors which translate these triplets to protein within the context of the mRNA. The tRNA identity elements assure the correct aminoacylation of the tRNA with the cognate amino acid by the aminoacyl-tRNA-synt...

journal_title：Biochemical and biophysical research communications

authors： Eichert A,Perbandt M,Oberthür D,Schreiber A,Fürste JP,Betzel C,Erdmann VA,Förster C

更新日期：2009-07-17 00:00:00

abstract：:A 13 kb rat Cu/ZnSOD genomic clone has been purified from a rat liver genomic library and completely characterized by restriction mapping, detailed sequencing and Southern blot analysis. This gene spans approximately 6 kb and contains five exons and four introns. Comparison of rat, mouse, and human Cu/ZnSOD genes reve...

journal_title：Biochemical and biophysical research communications

authors： Hsu JL,Visner GA,Burr IA,Nick HS

更新日期：1992-07-31 00:00:00

abstract：:The production of recombinant hepatitis B virus surface antigen (rHBsAg) purified by immunoaffinity chromatography with monoclonal antibodies is used to obtain a vaccine against this virus. Monoclonal antibodies to rHBsAg from mouse ascites have been purified by Staphylococcal Protein A (SpA)--prior coupling to Sephar...

journal_title：Biochemical and biophysical research communications

authors： Valdés Veliz R,García J,Reyes B,Muñoz L,Alvarez T,Padilla S,Abrahantes Mdel C,Zubiaurrez J,Agraz A,Marrero A

更新日期：2003-04-11 00:00:00

abstract：:Rheumatoid arthritis (RA) is an autoimmune inflammatory disease exhibited most commonly in joints. We found that the expression of C1qtnf3, which encodes C1q/TNF-related protein 3 (CTRP3), was highly increased in two mouse RA models with different etiology. To elucidate the pathogenic roles of CTRP3 in the development...

journal_title：Biochemical and biophysical research communications

authors： Murayama MA,Kakuta S,Maruhashi T,Shimizu K,Seno A,Kubo S,Sato N,Saijo S,Hattori M,Iwakura Y

更新日期：2014-01-03 00:00:00

abstract：:The paired-like homeobox-containing gene Ehox plays a role in embryonic stem cell differentiation and is highly expressed in the developing placenta and thymus. To understand the mechanisms of regulation of Ehox gene expression, the 5'-flanking region of the Ehox gene was isolated from a mouse BAC library. 5'-RACE ana...

journal_title：Biochemical and biophysical research communications

authors： Lee WK,Kim YM,Malik N,Ma C,Westphal H

更新日期：2006-03-03 00:00:00

abstract：:This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal). This article has been retracted at the request of the authors. The authors have indicated that Fig. 1D data originated from another source not specified in the ar...

journal_title：Biochemical and biophysical research communications

authors： Park YY,Kim SH,Kim YJ,Kim SY,Lee TH,Lee IK,Park SB,Choi HS

更新日期：2019-08-06 00:00:00

abstract：:For influenza H5N1 hemagglutinin, a switch from SA-alpha-2, 3-Gal to SA-alpha-2, 6-Gal receptor specificity is a critical step leading to the conversion from avian-to-human to human-to-human infection. Therefore, the understanding of the binding modes of SA-alpha-2, 3-Gal and SA-alpha-2, 6-Gal to H5N1 hemagglutinin wi...

journal_title：Biochemical and biophysical research communications

authors： Li M,Wang B

更新日期：2006-09-01 00:00:00

abstract：:Branched-chain amino acids (BCAAs) modulate various cellular functions, in addition to providing substrates for the production of proteins. In this study, we examined the effect of BCAAs on the secretion of hepatocyte growth factor (HGF) by hepatic stellate cells. A hepatic stellate cell clone was cultured in medium s...

journal_title：Biochemical and biophysical research communications

authors： Tomiya T,Inoue Y,Yanase M,Arai M,Ikeda H,Tejima K,Nagashima K,Nishikawa T,Fujiwara K

更新日期：2002-10-11 00:00:00

abstract：:In order to search for novel estrogen-responsive genes, we performed serial analysis of gene expression (SAGE) for estrogen-treated MCF-7 human breast cancer cells. SAGE analysis of 31,000 and 30,856 tags from non-treated and 17 beta-estradiol (E2)-treated cells for 24 h, respectively, facilitated the identification o...

journal_title：Biochemical and biophysical research communications

authors： Inadera H,Hashimoto S,Dong HY,Suzuki T,Nagai S,Yamashita T,Toyoda N,Matsushima K

更新日期：2000-08-18 00:00:00

abstract：:We have classified microvesicles into two subtypes: larger MVs released upon stimulation of prostate cancer cells, sMVs, and smaller cMVs, released constitutively. cMVs are released as part of cell metabolism and sMVs, released at 10-fold higher levels, produced upon activation, including sublytic C5b-9. From electron...

journal_title：Biochemical and biophysical research communications

authors： Stratton D,Moore C,Antwi-Baffour S,Lange S,Inal J

更新日期：2015-05-08 00:00:00

abstract：:An alternative molecular biology strategy is needed to characterize cholinephosphotransferase (CPT) gene because of the complexity of the problem associated with the solubilization of the membrane-bound enzyme without denaturation. We have synthesized five heterologous oligonucleotide probes based on the published yea...

journal_title：Biochemical and biophysical research communications

authors： Das SK,Beg O,Mukherjee S

更新日期：1997-12-18 00:00:00

abstract：:Using circular dichroism, fluorescence, and infrared spectroscopies, we studied the secondary structure of purified hamster PrP(C) in the presence of the mild, nonionic detergent octylglucoside. Under these native conditions, PrP(C) displayed an unexpectedly high beta-sheet component, intermediate between the values p...

journal_title：Biochemical and biophysical research communications

authors： Pergami P,Bramanti E,Ascoli GA

更新日期：1999-11-02 00:00:00

abstract：:Integrins alpha(M)beta(2) plays important role on leukocytes, such as adhesion, migration, phagocytosis, and apoptosis. It was hypothesized that homomeric associations of integrin subunits provide a driving force for integrins activation, and simultaneously inducing the formation of integrins clusters. However, experi...

journal_title：Biochemical and biophysical research communications

authors： Fu G,Wang C,Wang GY,Chen YZ,He C,Xu ZZ

更新日期：2006-12-29 00:00:00

abstract：:We designed an experimental approach to differentiate the kinetics of protein binding to a lipid membrane from the kinetics of the associated conformational change in the protein. We measured the fluorescence intensity of the single Trp6 in chicken liver bile acid-binding protein (L-BABP) as a function of time after m...

journal_title：Biochemical and biophysical research communications

authors： Galassi V,Nolan V,Villarreal MA,Perduca M,Monaco HL,Montich GG

更新日期：2009-05-15 00:00:00

abstract：:By its antioxidant effect, molecular hydrogen gas (H2) was reported to protect organs from tissue damage induced by ischemia reperfusion. To evaluate its anti-inflammatory effects, we established a mouse model of human inflammatory bowel disease (IBD) by supplying mice with water containing (1) dextran sodium sulfate ...

journal_title：Biochemical and biophysical research communications

authors： Kajiya M,Silva MJ,Sato K,Ouhara K,Kawai T

更新日期：2009-08-14 00:00:00

abstract：:Homocysteine is an accepted risk factor when its plasma level exceeds the physiological upper limit of 12 mumol/L. We found in vitro that homocysteine is able to lyse the erythrocytes (RBCs) at higher concentrations than 15 mumol/L only when activated polymorphonuclear leukocytes (PMNL) are present. The hemolytic effe...

journal_title：Biochemical and biophysical research communications

authors： Olinescu R,Kummerow FA,Handler B,Fleischer L

更新日期：1996-09-24 00:00:00

abstract：:Non-small cell lung cancer (NSCLC) has been identified as a leading cause of tumor-associated death around the world. Presently, it is necessary to find effective and safe therapy for its treatment in clinic. Jervine (Jer), a sterodial alkaloid from rhizomes of Veratrum album, exhibits anti-inflammatory and anti-cance...

journal_title：Biochemical and biophysical research communications

authors： Lei W,Huo Z

更新日期：2020-12-10 00:00:00

abstract：:The post-translational modification of histones has been implicated in the regulation of cellular lifespan. Previously, we reported that cellular aging is associated with increased ubiquitylation of histone H2B and methylation of histone H3 at lysines 4 and 79 in yeast telomeric heterochromatin. Here, we show the anta...

journal_title：Biochemical and biophysical research communications

authors： Ryu HY,Rhie BH,Ahn SH

更新日期：2014-03-28 00:00:00

abstract：:Streptokinase (SK), an extracellular protein of several haemolytic strains of Streptococcus, is utilized as a potent thrombolytic agent for the treatment of various myocardial disorders. Functional properties of SK remain unchanged when the first 13 N-terminal amino acid (aa) residues are removed. At present, role of ...

journal_title：Biochemical and biophysical research communications

authors： Pratap J,Kaur J,RajaMohan G,Singh D,Dikshit KL

更新日期：1996-10-03 00:00:00

abstract：:Atrial fibrillation (AF) is the most common cardiac arrhythmia in the clinic, and accounts for more than 15% of strokes. Mutations in cardiac sodium channel alpha, beta1 and beta2 subunit genes (SCN5A, SCN1B, and SCN2B) have been identified in AF patients. We hypothesize that mutations in the sodium channel beta3 subu...

journal_title：Biochemical and biophysical research communications

authors： Wang P,Yang Q,Wu X,Yang Y,Shi L,Wang C,Wu G,Xia Y,Yang B,Zhang R,Xu C,Cheng X,Li S,Zhao Y,Fu F,Liao Y,Fang F,Chen Q,Tu X,Wang QK

更新日期：2010-07-16 00:00:00

abstract：:Bolus intravenous injection of arachidonic acid (10 mg/kg) in the rat led to the appearance of hepoxilin A3 in the circulation. The product was assayed as the Me t-BDMSi derivative of its stable trihydroxy product trioxilin A3, by capillary gas chromatography-electron impact mass spectrometry using the stable deuteriu...

journal_title：Biochemical and biophysical research communications

authors： Pace-Asciak CR,Lee SP,Martin JM

更新日期：1987-09-30 00:00:00

abstract：:Epigenetics plays a role in the regulation of gene expression. Epigenetic changes control gene expression at the transcriptional level. Our previous study suggested that the La protein, which is mainly localized in the nucleus, was associated with hepatitis A virus (HAV) internal ribosomal entry site (IRES)-mediated t...

journal_title：Biochemical and biophysical research communications

authors： Kanda T,Sasaki R,Nakamoto S,Haga Y,Nakamura M,Shirasawa H,Okamoto H,Yokosuka O

更新日期：2015-10-23 00:00:00

abstract：:Gaucher disease (GD) is the most common lysosomal storage disorder (LSD) and is divided into three phenotypes, I, II, and III. Type I is the most prevalent form and has its onset in adulthood. The degree of endoplasmic reticulum (ER) stress is one of the factors that determine GD severity. It has recently been reporte...

journal_title：Biochemical and biophysical research communications

authors： Lee YJ,Kim SJ,Heo TH

更新日期：2011-09-23 00:00:00

abstract：:Poly(ADP-ribose) glycohydrolase (PARG) is a major enzyme that plays a role in the degradation of poly(ADP-ribose) (PAR). PARG deficiency reportedly sensitizes cells to the effects of radiation. In lung cancer, however, it has not been fully elucidated. Here, we investigated whether PARG siRNA contributes to an increas...

journal_title：Biochemical and biophysical research communications

authors： Nakadate Y,Kodera Y,Kitamura Y,Tachibana T,Tamura T,Koizumi F

更新日期：2013-11-29 00:00:00