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Leucine stimulates the secretion of hepatocyte growth factor by hepatic stellate cells.

Abstract：

:Branched-chain amino acids (BCAAs) modulate various cellular functions, in addition to providing substrates for the production of proteins. In this study, we examined the effect of BCAAs on the secretion of hepatocyte growth factor (HGF) by hepatic stellate cells. A hepatic stellate cell clone was cultured in medium supplemented with various concentrations of valine, leucine, or isoleucine. Of these BCAAs, leucine markedly induced an increase in the levels of HGF in the medium in a dose-dependent manner. The addition of valine or isoleucine had no significant effect on HGF levels in the medium. The difference in levels of HGF in the medium between leucine-treated and non-treated cells was enhanced by the incubation period. These results demonstrate that, among BCAAs, leucine stimulates the secretion of HGF by cultured hepatic stellate cells.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Tomiya T,Inoue Y,Yanase M,Arai M,Ikeda H,Tejima K,Nagashima K,Nishikawa T,Fujiwara K

doi

10.1016/s0006-291x(02)02339-2

subject

Has Abstract

pub_date

2002-10-11 00:00:00

pages

1108-11

issue

5

eissn

0006-291X

issn

1090-2104

pii

S0006291X02023392

journal_volume

297

pub_type

杂志文章

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