Abstract:
:The present study demonstrates that exposure of human thyroid slices to thyrotropin causes an increase in phospholipid metabolism as measured by an increased incorporation of myo-2-[3H]-inositol into phosphatidylinositol, the generation of InsP3 and formation of GInsP as well as metabolism of phosphatidylcholine and phosphatidic acid. These results indicate that adenosine, probably via the A1 type of P1 receptor, modulates both incorporation of labelled substrate into thyroid slices and its metabolism to active compounds which could play a role in a cell signalling system. These observations confirmed suggestions about the physiological role of the phosphatidylinositol pathway in signalling action of thyrotropin and purinergic receptors in human thyroid.
journal_name
Biochem Biophys Res Communjournal_title
Biochemical and biophysical research communicationsauthors
Mosko P,Zarzycki W,Jaroszewicz L,Kinalska Idoi
10.1006/bbrc.1994.1830subject
Has Abstractpub_date
1994-06-30 00:00:00pages
1182-8issue
3eissn
0006-291Xissn
1090-2104pii
S0006-291X(84)71830-4journal_volume
201pub_type
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journal_title:Biochemical and biophysical research communications
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pub_type: 杂志文章
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更新日期:1994-10-14 00:00:00
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pub_type: 杂志文章
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更新日期:1999-07-14 00:00:00