Lipid conjugates of antiretroviral agents. I. Azidothymidine-monophosphate-diglyceride: anti-HIV activity, physical properties, and interaction with plasma proteins.


:3'-Azido-3'-deoxythymidine-5'-phosphate diglyceride (16:0/18:1 omega 9), a phosphatic acid conjugate of AZT, is active against HIV replication in H9 cells and syncytia formation in MOLT-3 cells. The activities rank as AZT greater than pure conjugate greater than conjugate in mixed liposomes, with the pure conjugate having about one-third the activity of free AZT. The compound binds very rapidly to serum lipoproteins, but not to serum albumin, alpha and beta globulins, or red cells. Pancreatic phospholipase A2 hydrolyzes it to the lysophosphatidic acid conjugate.


Steim JM,Camaioni Neto C,Sarin PS,Sun DK,Sehgal RK,Turcotte JG




Has Abstract


1990-08-31 00:00:00














  • Intracellular cAMP contents regulate NAMPT expression via induction of C/EBPβ in adipocytes.

    abstract::A decline in intracellular nicotinamide adenine mononucleotide (NAD+) causes adipose tissue dysfunction. Nicotinamide phosphoribosyltransferase (NAMPT) catalyzes the rate-limiting step in the NAD+ biosynthesis pathway. However, the molecular mechanism that mediates regulation of NAMPT expression in adipocytes is yet t...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Mitani T,Watanabe S,Wada K,Fujii H,Nakamura S,Katayama S

    更新日期:2020-02-12 00:00:00

  • Multi-wavelength immunoassays using surface plasmon-coupled emission.

    abstract::We describe a new method for multi-wavelength immunoassays using surface plasmon-coupled emission (SPCE). This phenomenon is coupling of excited fluorophores with a nearby thin metal film, in our case silver, resulting in strongly directional emission into the underlying glass substrate. The angle at which the radiati...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Matveeva E,Malicka J,Gryczynski I,Gryczynski Z,Lakowicz JR

    更新日期:2004-01-16 00:00:00

  • RvD1 inhibits TNFα-induced c-Myc expression in normal intestinal epithelial cells and destabilizes hyper-expressed c-Myc in colon cancer cells.

    abstract::Inflammatory bowel diseases, including ulcerative colitis and Crohn's disease, are persistent disorders that lead to development of colitis-associated cancer (CAC). Facilitated resolution of colitis has been addressed as a novel therapeutic strategy to control development of CAC. Resolvin D1 (RvD1) is an endogenous li...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Zhong X,Lee HN,Surh YJ

    更新日期:2018-02-05 00:00:00

  • Sequence homology between prokaryotic and eukaryotic forms of serine hydroxymethyltransferase.

    abstract::The sequence of tryptic and chymotryptic peptides from cytosolic and mitochondrial rabbit liver serine hydroxymethyltransferase are compared to the proposed sequence of a protein coded for by the glyA gene of Escherichia coli. The E. coli glyA gene is believed to code for serine hydroxymethyltransferase. Extensive seq...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Barra D,Martini F,Angelaccio S,Bossa F,Gavilanes F,Peterson D,Bullis B,Schirch L

    更新日期:1983-11-15 00:00:00

  • DNA sequence analysis of spontaneous tonB deletion mutations in a polA1 strain of Escherichia coli K12.

    abstract::By DNA sequence analysis, we have determined a spectrum of 61 spontaneous mutations occurring in the endogenous tonB gene in the polA1 strain of Escherichia coli. The overall mutation frequency was approximately 2.4-fold higher in the polA1 strain and this was attributable to enhanced rates of deletion and frameshift ...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Agemizu Y,Uematsu N,Yamamoto K

    更新日期:1999-08-11 00:00:00

  • A novel and potent ribonuclease from fruiting bodies of the mushroom Pleurotus pulmonarius.

    abstract::A ribonuclease (RNase), with an N-terminal sequence different from those of ribonucleases from the mushrooms Irpex lacteus, Lentinus edodes, Pleurotus ostreatus, Pleurotus tuber-regium, and Volvariella volvacea, was purified from fruiting bodies of the edible mushroom Pleurotus pulmonarius. The N-terminal sequence of ...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Ye XY,Ng TB

    更新日期:2002-05-03 00:00:00

  • A characterization of the H3 and H4 histone genes from the ascidian Styela plicata.

    abstract::Information about histone sequences and histone gene organization from invertebrate chordates is completely lacking. A genomic clone containing linked H3 and H4 histone genes from the urochordate Styela plicata was analyzed. The nucleotide sequence indicates that the two genes are transcribed in opposite directions an...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Ishaq AI,Rizvi SB,Wells DE,Tomlinson CR

    更新日期:1993-07-30 00:00:00

  • Translationally controlled tumor protein is a novel heat shock protein with chaperone-like activity.

    abstract::Translationally controlled tumor protein (TCTP) is often designated as a stress-related protein because of its highly regulated expression in stress conditions. Following a thermal shock, TCTP expression is highly upregulated in a variety of cells. However, at present it is not known whether this upregulation has any ...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Gnanasekar M,Dakshinamoorthy G,Ramaswamy K

    更新日期:2009-08-21 00:00:00

  • Cellular prion protein in ovine milk.

    abstract::Cellular prion protein, PrP(C), is essential for the development of prion diseases where it is considered to be a substrate for the formation of the disease-associated conformer, PrP(Sc). In sheep, PrP(C) is abundant in neuronal tissue and is also found at lower concentrations in a range of non-neuronal tissues, inclu...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Maddison BC,Whitelam GC,Gough KC

    更新日期:2007-02-02 00:00:00

  • Interleukin-1beta-induced apoptosis through adenylyl cyclase and ERK1/2 inhibition in primary cultured thyroid cells.

    abstract::The programmed cell death plays a crucial role in the regulation of numerous physiological and pathological phenomena. In this study, we show that interleukin-1 beta (IL-1beta) induces an early production of endogenous ceramides via N-sphingomyelinase (N-Smase) as well as an inhibition of adenylyl cyclase activity in ...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: El Btaouri H,Rath G,Morjani H,Schneider C,Petitfrere E,Antonicelli F,Martiny L

    更新日期:2006-01-13 00:00:00

  • Dystrophin-related protein in the fetal and denervated skeletal muscles of normal and mdx mice.

    abstract::The amino acid sequence of the polyclonal antibodies we developed against the carboxyl terminus of the dystrophin-related protein, the putative gene product of B3 cDNA, had no homologous sequence to the dystrophin molecule except for two amino acids located at its ends for immunization. By immunohistochemical examinat...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Takemitsu M,Ishiura S,Koga R,Kamakura K,Arahata K,Nonaka I,Sugita H

    更新日期:1991-11-14 00:00:00

  • Differential expression of components of the microRNA machinery during mouse organogenesis.

    abstract::MicroRNA (miRNA)-mediated gene silencing has recently emerged as a major mechanism of gene expression regulation during development in a variety of species. Little is known, however, about the presence of components of miRNA machinery in mammalian organogenesis. In this study, we report that members of the Argonaute (...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Lü J,Qian J,Chen F,Tang X,Li C,Cardoso WV

    更新日期:2005-08-26 00:00:00

  • Purification and molecular cloning of a novel calcium-binding protein, p26olf, in the frog olfactory epithelium.

    abstract::Olfactory adaptation requires the change of intracellular calcium concentration during stimuli. To contribute in the study of the molecular mechanism of calcium-dependent regulations in olfactory receptor cells, we isolated a novel 26-kDa Ca2+-binding protein named p26olf from the frog olfactory epithelium after four ...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Miwa N,Kobayashi M,Takamatsu K,Kawamura S

    更新日期:1998-10-29 00:00:00

  • Significance of glycosylation in Notch signaling.

    abstract::Notch signaling is essential for cell-fate specification in metazoans, and dysregulation of the pathway leads to a variety of human diseases including heart and vascular defects as well as cancer. Glycosylation of the Notch extracellular domain has emerged as an elegant means for regulating Notch activity, especially ...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章,评审


    authors: Takeuchi H,Haltiwanger RS

    更新日期:2014-10-17 00:00:00

  • Identification of the peptide region that folds native conformation in the early stage of the renaturation of reduced lysozyme.

    abstract::We prepared three peptide fragments (fg.59-105, fg.63-105 and fg.64-105) by the BrCN cleavage of mutant lysozymes where Ile58, Trp62 and Trp63 were mutated to Met, respectively. From the analysis of formation of the disulfide bonds among Cys64, Cys76, Cys80 and Cys94 in the renaturation of each peptide fragment from t...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Ueda T,Ohkuri T,Imoto T

    更新日期:1996-11-01 00:00:00

  • Dual effect of insulin on in vitro leptin secretion by adipose tissue.

    abstract::Although it is widely accepted that insulin stimulates leptin secretion, a dual action was observed using a validated in vitro system, i.e., an early (less than 48 h) inhibitory action, followed later (48-96 h) by a clear-cut stimulation. While the inhibitory phase was observed at every glucose concentration tested (f...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Casabiell X,Piñeiro V,De la Cruz LF,Gualillo O,Folgar L,Diéguez C,Casanueva FF

    更新日期:2000-09-24 00:00:00

  • A new sialoglycoprotein from rat seminal vesicle and its association with semen coagulum.

    abstract::By radiolabeling using NaIO4/[3H]KBH4, a new sialoglycoprotein with Mr of 19,000 was found in the secretion of rat seminal vesicle. It was shown to interact non-covalently with semen coagulum. It existed in three acidic forms with pI values of 4.1, 3.7 and 2.9 and possessed high contents of sialic acids and acidic ami...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Limpaseni T,Chulavatnatol M

    更新日期:1986-04-29 00:00:00

  • 8-Oxo-2'-deoxyguanosine ameliorates features of metabolic syndrome in obese mice.

    abstract::Metabolic syndrome describes a group of clinical features that together increase the incidence of coronary artery disease, stroke and type 2 diabetes. Insulin resistance is a major risk factor for developing metabolic syndrome. A chronic state of inflammation accompanies the accumulation of surplus lipids in adipose a...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Ko SH,Lee JK,Lee HJ,Ye SK,Kim HS,Chung MH

    更新日期:2014-01-10 00:00:00

  • PPARγ alleviated hepatocyte steatosis through reducing SOCS3 by inhibiting JAK2/STAT3 pathway.

    abstract::Peroxisome proliferator-activated receptor gamma (PPARγ) participates in the process of insulin resistance (IR), a crucial pathophysiology in non-alcoholic fatty liver disease (NAFLD). Meanwhile, suppressor of cytokine signaling3 (SOCS3) also regulates IR in NAFLD. Both PPARγ and SOCS3 play a role in NAFLD through reg...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Bi J,Sun K,Wu H,Chen X,Tang H,Mao J

    更新日期:2018-04-15 00:00:00

  • AtVps11 is essential for vacuole biogenesis in embryo and participates in pollen tube growth in Arabidopsis.

    abstract::Vacuoles are multiple functional and essential organelles in plants. Studies in Saccharomyces cerevisiae had identified a tethering factor HOPS (Homotypic Fusion and Vacuolar Protein Sorting) complex that plays a critical role in vacuole biogenesis. The HOPS complex consists of four core subunits (Vps11, Vps16, Vps18 ...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Tan X,Wei J,Li B,Wang M,Bao Y

    更新日期:2017-09-23 00:00:00

  • Histone H1-stimulated phosphorylase phosphatase from rabbit skeletal muscle.

    abstract::A major rabbit skeletal muscle phosphorylase phosphatase activity which is markedly stimulated by histone H1 has been resolved from inhibitor-sensitive phosphorylase phosphatase (type-1 phosphatase), glycogen synthase kinase 3-activated phosphatase, phosphatase heat-stable inhibitor proteins, and alkaline phosphatase ...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Mellgren RL,Schlender KK

    更新日期:1983-12-16 00:00:00

  • Cathepsin D inactivates cysteine proteinase inhibitors, cystatins.

    abstract::The formation of inactive complexes in excess molar amounts of human cathepsins H and L with their protein inhibitors human stefin A, human stefin B and chicken cystatin at pH 5.6 has been shown by measurement of enzyme activity coupled with reverse-phase HPLC not to involve covalent cleavage of the inhibitors. Inhibi...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Lenarcic B,Kos J,Dolenc I,Lucovnik P,Krizaj I,Turk V

    更新日期:1988-07-29 00:00:00

  • A differentially expressed prion gene mRNA is found in prion-infected mouse brains and in N2A cells but not in uninfected mice.

    abstract::The transmissible spongiform encephalopathies comprise a group of fatal neurodegenerative diseases that are characterized by the conversion of the normal host cellular prion protein (PrPC) to the abnormal protease-resistant isoform PrPSC. Distinct alterations of transcriptional regulation during disease progression co...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Schröder B,Groschup M,Hunsmann G,Bodemer W

    更新日期:1998-10-20 00:00:00

  • An explanation for the disparate effects of synthetic peptides corresponding to human follicle-stimulating hormone beta-subunit receptor binding regions (33-53) and (81-95) and their serine analogs on steroidogenesis in cultured rat Sertoli cells.

    abstract::We have recently reported that synthetic peptide amides corresponding to regions of human FSH beta-subunit, hFSH-beta-(33-53) and hFSH-beta-(81-95), bind to receptor and stimulate estradiol biosynthesis by cultured rat Sertoli cells. Because of experimental difficulties caused by the presence of free sulfhydryl groups...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Grasso P,Crabb JW,Reichert LE Jr

    更新日期:1993-01-15 00:00:00

  • Nuclear-factor-kappaB (NF-kappaB) and radical oxygen species play contrary roles in transforming growth factor-beta1 (TGF-beta1)-induced apoptosis in hepatocellular carcinoma (HCC) cells.

    abstract::Nuclear-Factor-kappaB (NF-kappaBeta can counteract transforming growth factor-beta1 (TGF-beta1)-induced apoptosis in malignant hepatocytes through up-regulation of its downstream genes, such as X-linked inhibitor of apoptosis protein (XIAP). Reports have demonstrated that TGF-beta1 can induce oxidative stress, and c-J...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Wang F,Kaur S,Cavin LG,Arsura M

    更新日期:2008-12-26 00:00:00

  • Two independent domains of factor VIII co-expressed using recombinant vaccinia viruses have procoagulant activity.

    abstract::Using recombinant DNA technology, the NH2 and COOH terminal domains of the human Factor VIII molecule were co-expressed in baby hamster kidney 21 (BHK21) cells using the vaccinia virus system. Procoagulant activity was detectable in cell supernatants, thus suggesting that the central portion present in the FVIII prote...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Pavirani A,Meulien P,Harrer H,Dott K,Mischler F,Wiesel ML,Mazurier C,Cazenave JP,Lecocq JP

    更新日期:1987-05-29 00:00:00

  • Wnt/β-catenin pathway mediates (-)-Epigallocatechin-3-gallate (EGCG) inhibition of lung cancer stem cells.

    abstract::Cancer stem cells (CSCs) play essential role in the progression of many tumors. Wnt/β-catenin pathway is crucial in maintaining the stemness of CSCs. (-)-Epigallocatechin-3-gallate (EGCG), the major bioactive component in green tea, has been shown to possess anti-cancer activity. To date, the interventional effect of ...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Zhu J,Jiang Y,Yang X,Wang S,Xie C,Li X,Li Y,Chen Y,Wang X,Meng Y,Zhu M,Wu R,Huang C,Ma X,Geng S,Wu J,Zhong C

    更新日期:2017-01-01 00:00:00

  • UDP-GalNAc:NeuAc alpha 2,3Gal beta-R (GalNAc to Gal) beta 1,4-N-acetylgalactosaminyltransferase responsible for the Sda specificity in human colon carcinoma CaCo-2 cell line.

    abstract::The UDP-GalNAc:NeuAc alpha 2,3Gal beta-R (GalNAc to Gal) beta-1,4-N-acetylgalactosaminyltransferase (beta 1,4GalNAc-transferase) is the enzyme responsible for the addition of the immunodominant sugar of the Sda isto-blood group determinant. In humans the enzyme is mainly expressed in the large intestine. We screened n...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Malagolini N,Dall'Olio F,Serafini-Cessi F

    更新日期:1991-10-31 00:00:00

  • A new fluorescence-based method to monitor the pH in the thylakoid lumen using GFP variants.

    abstract::The ΔpH-dependent/Tat pathway is unique for using only the proton motive force for driving proteins transport across the thylakoid membrane in chloroplasts. 9-aminoacridine fluorescence quenching is widely used to monitor the ΔpH developed across the thylakoid membrane in the light. However, this method suffers from l...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Yang H,Pu X,Wang L,Liu L,Theg SM

    更新日期:2017-04-22 00:00:00

  • MtDNA mutations associated with Leber's hereditary optic neuropathy: studies on cytoplasmic hybrid (cybrid) cells.

    abstract::Leber's hereditary optic neuropathy (LHON) has been associated with "primary" and "secondary" mtDNA missense point mutations, and a synergistic role has been proposed for secondary mutations. No previous study has investigated the effects of LHON primary or primary plus secondary mutations on the respiratory competenc...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Vergani L,Martinuzzi A,Carelli V,Cortelli P,Montagna P,Schievano G,Carrozzo R,Angelini C,Lugaresi E

    更新日期:1995-05-25 00:00:00