Abstract:
:3'-Azido-3'-deoxythymidine-5'-phosphate diglyceride (16:0/18:1 omega 9), a phosphatic acid conjugate of AZT, is active against HIV replication in H9 cells and syncytia formation in MOLT-3 cells. The activities rank as AZT greater than pure conjugate greater than conjugate in mixed liposomes, with the pure conjugate having about one-third the activity of free AZT. The compound binds very rapidly to serum lipoproteins, but not to serum albumin, alpha and beta globulins, or red cells. Pancreatic phospholipase A2 hydrolyzes it to the lysophosphatidic acid conjugate.
journal_name
Biochem Biophys Res Communjournal_title
Biochemical and biophysical research communicationsauthors
Steim JM,Camaioni Neto C,Sarin PS,Sun DK,Sehgal RK,Turcotte JGdoi
10.1016/0006-291x(90)91414-nsubject
Has Abstractpub_date
1990-08-31 00:00:00pages
451-7issue
1eissn
0006-291Xissn
1090-2104pii
0006-291X(90)91414-Njournal_volume
171pub_type
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