Full-length and truncated versions of the hepatitis B virus (HBV) X protein (pX) transactivate the cmyc protooncogene at the transcriptional level.

abstract：:Triacsin C, a product of Streptmyces sp. SK-1894, was previously reported as an inhibitor of long chain acyl-CoA synthetase. Pretreatment with triacsin C (500 nM) for 1h enhanced production of platelet-activating factor in rat neutrophils, followed by stimulation with A23187 or fMLP. Amount of lyso-PAF was also augume...

journal_title：Biochemical and biophysical research communications

authors： Hayashi M,Imai Y,Naraba H,Tomoda H,Omura S,Oh-ishi S

更新日期：1992-11-16 00:00:00

abstract：:By performing immunofluorescence staining assays in confluent COS-7 cells, hepatitis B virus core, small surface and large surface proteins were found to localize largely in the nucleus, diffusely in the cytoplasm, and accumulatively in a perinuclear area, respectively. When two proteins were co-expressed, the core pr...

journal_title：Biochemical and biophysical research communications

authors： Yeh CT,Ou JH,Chu CM,Liaw YF

更新日期：1994-09-15 00:00:00

abstract：:Interleukin 6 is a pleiotropic cytokine produced in the central nervous system (CNS) that has been involved in both direct neurotrophic activities and in the regulation of the production of acute phase proteins both at peripheral and central levels. In rat cortical type I astrocytes, interleukin 6 release is under the...

journal_title：Biochemical and biophysical research communications

authors： Grimaldi M,Florio T,Schettini G

更新日期：1997-06-09 00:00:00

abstract：:Heat shock cognate protein 70 (HSC70) has been shown to bind to the peptide corresponding to amino acids 197 to 216 of human T-cell lymphotropic virus type I (HTLV-I) envelope protein, gp46, and an anti-HSC70 monoclonal antibody (mAb) inhibits HTLV-I-induced syncytium formation. These findings suggest that HSC70 is ne...

journal_title：Biochemical and biophysical research communications

authors： Fang D,Haraguchi Y,Jinno A,Soda Y,Shimizu N,Hoshino H

更新日期：1999-08-02 00:00:00

abstract：:Adiponectin, an adipocyte-derived hormone, attenuates the production of TNFalpha by activated human macrophages. In the present study, we used porcine blood-derived macrophages to test the hypothesis that the anti-inflammatory action of adiponectin includes suppression of IL6 and an induction of IL10. Adiponectin supp...

journal_title：Biochemical and biophysical research communications

authors： Wulster-Radcliffe MC,Ajuwon KM,Wang J,Christian JA,Spurlock ME

更新日期：2004-04-09 00:00:00

abstract：:Pinin (Pnn) is a nuclear speckle-associated SR-like protein. The N-terminal region of the Pnn protein sequence is highly conserved from mammals to insects, but the C-terminal RS domain-containing region is absent in lower species. The N-terminal coiled-coil domain (CCD) is, therefore, of interest not only from a funct...

journal_title：Biochemical and biophysical research communications

authors： Wu HP,Hsu SY,Wu WA,Hu JW,Ouyang P

更新日期：2014-01-03 00:00:00

abstract：:The cooperative nature of interaction of cationic surfactants with short oligonucleotides leading to eventual stabilization of DNA duplexes is demonstrated. At submicellar concentrations and DNA:surfactant charge ratios of 0.2 to 0.8, the association of single chain (CTAB) and double chain (DOTAP) surfactants to oligo...

journal_title：Biochemical and biophysical research communications

authors： Pattarkine MV,Ganesh KN

更新日期：1999-09-16 00:00:00

abstract：:Novel conformation-specific antibodies were raised against a cyclic chimeric dodecapeptidyl multiple antigen peptide (cCD-MAP) constructed with a spacer-armed Gly-Asp dipeptide and two pentapeptides (S(169)-Q(170)-K(171)-E(172)-G(173) of CCR5 and E(179)-A(180)-D(181)-D(182)-R(183) of CXCR4) which are components of the...

journal_title：Biochemical and biophysical research communications

authors： Misumi S,Takamune N,Ido Y,Hayashi S,Endo M,Mukai R,Tachibana K,Umeda M,Shoji S

更新日期：2001-08-03 00:00:00

abstract：:Placental choriocarcinoma, a reproductive system carcinoma in women, has about 0.81% occurrence frequency in China, which leads to over 90% lethality due to indistinct pathogenesis and the absence of efficient therapeutic treatment. In the present study, using immunostaining and reverse transcription PCR, we reported ...

journal_title：Biochemical and biophysical research communications

authors： Peng S,Miao C,Li J,Fan X,Cao Y,Duan E

更新日期：2006-11-24 00:00:00

abstract：:Phosphatidylinositol 3-kinase (PI 3-kinase) was partially purified from rat liver cytosol and used to synthesize phosphatidylinositol 3,4,5-trisphosphate (PIP3), using phosphatidylinositol 4,5-bisphosphate (PIP2) as a substrate. Purified PIP3 (free of chromatographic oxalate) activated protein kinase C (PKC) in the pr...

journal_title：Biochemical and biophysical research communications

authors： Singh SS,Chauhan A,Brockerhoff H,Chauhan VP

更新日期：1993-08-31 00:00:00

abstract：:This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal). This article has been retracted at the request of the authors. The authors have indicated that Fig. 1D data originated from another source not specified in the ar...

journal_title：Biochemical and biophysical research communications

authors： Park YY,Kim SH,Kim YJ,Kim SY,Lee TH,Lee IK,Park SB,Choi HS

更新日期：2019-08-06 00:00:00

abstract：:Eicosanoid formation by transcellular routes can amplify the levels and types of lipid mediators within a local milieu. To evaluate the role of adhesion in this process, we assessed the influence of mAb against adhesion molecules on LTC4 generation by PMN-endothelial cell interaction. Transcellular LTC4 generation was...

journal_title：Biochemical and biophysical research communications

authors： Brady HR,Serhan CN

更新日期：1992-08-14 00:00:00

abstract：:The fate of [125I] lactoferrin after binding on its specific receptor on HT29-D4 cells, a clone of HT29 cells, was studied and compared with that of [125I]transferrin. Time courses of protein binding in relation with temperature clearly show that different mechanisms of ligand-transportation for the two glycoproteins ...

journal_title：Biochemical and biophysical research communications

authors： Roiron-Lagroux D,Figarella C

更新日期：1990-07-31 00:00:00

abstract：:Reversal of the plasma membrane Na(+)/Ca(2+) exchanger (NCX) has been shown to mediate Ca(2+) influx in response to activation of G-protein linked receptors. Functional coupling of reverse-mode NCX with canonical transient receptor potential channels (TRPC), specifically TRPC6, has recently been demonstrated by our la...

journal_title：Biochemical and biophysical research communications

authors： Syyong HT,Poburko D,Fameli N,van Breemen C

更新日期：2007-06-15 00:00:00

abstract：:A small fraction of tumor cells are thought to possess the potential for both multiple-lineage differentiation and self-renewal, which underlies the cancer stem cell hypothesis. However, the differentiation mechanisms of these cells have not been elucidated due to a lack of appropriate culture methods. Here, we establ...

journal_title：Biochemical and biophysical research communications

authors： Kawamata M,Katsuda T,Yamada Y,Ochiya T

更新日期：2017-01-22 00:00:00

abstract：:Non-photochemical quenching (NPQ) is the most important photoprotective system in higher plants. NPQ can be divided into several steps according to the timescale of relaxation of chlorophyll fluorescence after reaching a steady state (i.e., the fast phase, qE; middle phase, qZ or qT; and slow phase, qI). The dissipati...

journal_title：Biochemical and biophysical research communications

authors： Kohzuma K,Hikosaka K

更新日期：2018-03-25 00:00:00

abstract：:We have previously demonstrated that homeodomain proteins, MEIS1 and PBXs, transactivate the PF4 gene through the novel regulatory element termed TME. This study focuses on Pbx regulating protein 1 (PREP1), a MEIS1 homolog protein, for its transcriptional activity in the PF4 promoter. PREP1 binds to the TME in HEL cel...

journal_title：Biochemical and biophysical research communications

authors： Okada Y,Matsuura E,Nagai R,Sato T,Watanabe A,Morita I,Doi T

更新日期：2003-05-23 00:00:00

abstract：:BRCT(BRCA1) plays a major role in DNA repair pathway, and does so by recognizing the conserved sequence pSXXF in its target proteins. Remarkably, tetrapeptides containing pSXXF motif bind with high specificity and micromolar affinity. Here, we have characterized the binding interactions of pSXXF tetrapeptides using NM...

journal_title：Biochemical and biophysical research communications

authors： Joseph PR,Yuan Z,Kumar EA,Lokesh GL,Kizhake S,Rajarathnam K,Natarajan A

更新日期：2010-03-05 00:00:00

abstract：:Thioredoxin (TRX) is one of major components of thiol reducing systems. To investigate the molecular mechanism of TRX function in the lung tissue, we screened a human lung epithelial cell cDNA library for TRX-binding protein by yeast two-hybrid systems. We isolated a plasmid containing C-propeptide region of human pro...

journal_title：Biochemical and biophysical research communications

authors： Matsumoto K,Masutani H,Nishiyama A,Hashimoto S,Gon Y,Horie T,Yodoi J

更新日期：2002-07-19 00:00:00

abstract：:Bovine brain smg p25A, a guanine nucleotide-binding protein with a Mr of about 25,000, bound specifically GTP, guanosine 5'-(3-O-thio)triphosphate (GTP gamma S) and GDP. The initial velocities of the binding of GTP gamma S to GDP-bound smg p25A and the dissociation of GDP from this protein increased by decreasing Mg2+...

journal_title：Biochemical and biophysical research communications

authors： Shoji I,Kikuchi A,Kuroda S,Takai Y

更新日期：1989-07-14 00:00:00

abstract：:Prion protein (PrPc) is expressed in many tissues, both in human and animals. The scrapie isoform of PrPc has been shown to cause neurodegeneration. In other studies it has been demonstrated that overexpression of the PrP gene can result in nonneuronal tissue degradation. Little is known, however, about the normal fun...

journal_title：Biochemical and biophysical research communications

authors： Kniazeva M,Orman R,Terranova VP

更新日期：1997-05-08 00:00:00

abstract：:α-Isopropylmalate synthase (α-IPMS) is a multi-domain protein catalysing the condensation of α-ketoisovalerate (α-KIV) and acetyl coenzyme A (AcCoA) to form α-isopropylmalate. This reaction is the first committed step in the leucine biosynthetic pathway in bacteria and plants, and α-IPMS is allosterically regulated by...

journal_title：Biochemical and biophysical research communications

authors： Huisman FH,Squire CJ,Parker EJ

更新日期：2013-04-05 00:00:00

abstract：:To search autoantigens in autoimmune pancreatitis (AIP), we have screened the human pancreas cDNA library with a patient's serum and obtained 10 positive clones. Seven out of 10 clones were amylase alpha-2A, the autoantibody to which was specifically detected in sera from patients with AIP and fulminant type 1 diabete...

journal_title：Biochemical and biophysical research communications

authors： Takizawa S,Endo T,Wanjia X,Tanaka S,Takahashi M,Kobayashi T

更新日期：2009-08-14 00:00:00

abstract：:Nrf2 is a key regulator of many detoxifying enzyme genes, and cytoplasmic protein Keap1 represses the Nrf2 activity under quiescent conditions. Germ line deletion of the keap1 gene results in constitutive activation of Nrf2, but the pups unexpectedly died before weaning. To investigate how constitutive activation of N...

journal_title：Biochemical and biophysical research communications

authors： Okawa H,Motohashi H,Kobayashi A,Aburatani H,Kensler TW,Yamamoto M

更新日期：2006-01-06 00:00:00

abstract：:CMP-Kdn synthetase catalyses the reaction of sialic acids (Sia) and cytidine-5'-triphosphate (CTP) to the corresponding activated sugar nucleotide CMP-Sia and pyrophosphate PP(i). STD NMR experiments of a recombinant nucleotide cytidine-5'-monophosphate-3-deoxy-d-glycero-d-galacto-nonulosonic acid synthetase (CMP-Kdn ...

journal_title：Biochemical and biophysical research communications

authors： Haselhorst T,Münster-Kühnel AK,Stolz A,Oschlies M,Tiralongo J,Kitajima K,Gerardy-Schahn R,von Itzstein M

更新日期：2005-02-11 00:00:00

abstract：:The specific binding of leukotriene B4 to its receptor on human leukocyte membranes was enhanced in a dose-dependent manner by metal ions. Mg2+ and Ca2+ were the most potent followed by Mn2+ and Co2+. These divalent cations increased receptor density and did not affect the binding affinity. Addition of the same divale...

journal_title：Biochemical and biophysical research communications

authors： Ng CF,Haeggström JZ,Samuelsson B

更新日期：1997-07-18 00:00:00

abstract：:Exposure of pancreatic islet B-cells to D-glucose and many other insulinotropic agents results in an increase of cytoplasmic calcium concentration, which triggers the exocytosis of secretroy granules. Previous studies have demonstrated that calcium itself, at concentrations ranging from 2 to 18 mM, is able to induce a...

journal_title：Biochemical and biophysical research communications

authors： Rasschaert J,Malaisse WJ

更新日期：1999-11-02 00:00:00

abstract：:Microsomal vesicles prepared from rat adipocytes were immuno-adsorbed to formaldehyde-fixed Staphylococcus aureus cells (Pansorbin) coated with anti-human-erythrocyte-glucose-transporter IgG. More than 75% of the glucose transporter detected was precipitated. The glucose transporter was about 10-fold enriched by the a...

journal_title：Biochemical and biophysical research communications

authors： Ezaki O,Bono N,Itakura H,Kasahara M

更新日期：1989-03-31 00:00:00

abstract：:Adipose tissue is an endocrine organ that produces and secretes adipokines. The aim of this study was to identify genes predominantly expressed in human subcutaneous adipocytes. For this purpose, an algorithm was developed and DNA microarray expression profiles from 33 human tissues and cell types were used to select ...

journal_title：Biochemical and biophysical research communications

authors： Sjöholm K,Palming J,Lystig TC,Jennische E,Woodruff TK,Carlsson B,Carlsson LM

更新日期：2006-06-16 00:00:00

abstract：:Endostatin, a natural angiogenesis inhibitor, had been identified for years. It opened a new approach for cancer therapy. Sequence analysis revealed that endostatin is the NC1 domain (non-triple-helical domain) of collagen XVIII. In this report, the cDNA of NC1 domain of type VIII collagen (alpha 1) was cloned and exp...

journal_title：Biochemical and biophysical research communications

authors： Xu R,Yao ZY,Xin L,Zhang Q,Li TP,Gan RB

更新日期：2001-11-23 00:00:00