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Co-localization of a glucose transporter and the insulin receptor in microsomes of insulin-treated rat adipocytes.

Abstract：

:Microsomal vesicles prepared from rat adipocytes were immuno-adsorbed to formaldehyde-fixed Staphylococcus aureus cells (Pansorbin) coated with anti-human-erythrocyte-glucose-transporter IgG. More than 75% of the glucose transporter detected was precipitated. The glucose transporter was about 10-fold enriched by the adsorption procedure. On insulin treatment, the insulin receptor in plasma membranes was internalized and the receptor in the microsome fraction increased 5-fold. Thirty-five % of the insulin receptor in the microsome fraction was recovered with the glucose-transporter-containing vesicles. These observations indicate that on insulin treatment a considerable portion of the microsome vesicles containing the insulin receptor fuses or becomes tightly associated with ones containing the glucose transporter.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Ezaki O,Bono N,Itakura H,Kasahara M

doi

10.1016/0006-291x(89)92261-4

subject

Has Abstract

pub_date

1989-03-31 00:00:00

pages

1368-74

issue

3

eissn

0006-291X

issn

1090-2104

pii

0006-291X(89)92261-4

journal_volume

159

pub_type

杂志文章

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