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Alkylating agent methyl methanesulfonate (MMS) induces a wave of global protein hyperacetylation: implications in cancer cell death.

Abstract：

:Protein acetylation modification has been implicated in many cellular processes but the direct evidence for the involvement of protein acetylation in signal transduction is very limited. In the present study, we found that an alkylating agent methyl methanesulfonate (MMS) induces a robust and reversible hyperacetylation of both cytoplasmic and nuclear proteins during the early phase of the cellular response to MMS. Notably, the acetylation level upon MMS treatment was strongly correlated with the susceptibility of cancer cells, and the enhancement of MMS-induced acetylation by histone deacetylase (HDAC) inhibitors was shown to increase the cellular susceptibility. These results suggest protein acetylation is important for the cell death signal transduction pathway and indicate that the use of HDAC inhibitors for the treatment of cancer is relevant.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Lee MY,Kim MA,Kim HJ,Bae YS,Park JI,Kwak JY,Chung JH,Yun J

doi

10.1016/j.bbrc.2007.06.084

subject

Has Abstract

pub_date

2007-08-24 00:00:00

pages

483-9

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(07)01329-0

journal_volume

360

pub_type

杂志文章

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