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Identification of a sphingosine-sensitive Ca2+ channel in the plasma membrane of Leishmania mexicana.

Abstract：

:The disruption of the intracellular Ca(2+) homeostasis of Leishmania mexicana represents a major target for the action of drugs, such as amiodarone and miltefosine. However, little is known about the mechanism of Ca(2+) entry to these cells. Here we show the presence of a Ca(2+) channel in the plasma membrane of these parasites. This channel has many characteristics similar to the human L-type voltage-gated Ca(2+) channel. Thus, Ca(2+) entry is blocked by verapamil, nifedipine and diltiazem while Bay K 8644 opened this channel. However, different to its human counterpart, sphingosine was able to open this channel, while other well known sphingolipids had no effect. This fact could have important pharmacological implications.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Benaim G,García-Marchán Y,Reyes C,Uzcanga G,Figarella K

doi

10.1016/j.bbrc.2012.12.033

subject

Has Abstract

pub_date

2013-01-18 00:00:00

pages

1091-6

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(12)02362-5

journal_volume

430

pub_type

杂志文章

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