Abstract:
:S-100 protein and annexin II2-p11(2) were reported to inhibit and to stimulate the assembly of glial fibrillary acidic protein (GFAP), respectively, in a Ca(2+)-dependent manner. Here we show by a number of experimental approaches that S-100 protein contrasts all the effects of annexin II2-p11(2) on GFAP assembly and, conversely, that annexin II2-p11(2) contrasts the inhibitory effects of S-100 protein on GFAP assembly, in a dose-dependent manner in both cases. Altogether, these data suggest that two specific Ca2+ effectors, i.e., annexin II2-p11(2) and S-100 protein, might regulate the state of assembly of glial filaments in a concerted manner.
journal_name
Biochem Biophys Res Communjournal_title
Biochemical and biophysical research communicationsauthors
Bianchi R,Garbuglia M,Verzini M,Giambanco I,Spreca A,Donato Rdoi
10.1006/bbrc.1995.1421subject
Has Abstractpub_date
1995-03-28 00:00:00pages
910-8issue
3eissn
0006-291Xissn
1090-2104pii
S0006291X85714210journal_volume
208pub_type
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