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Calpain inhibitor-induced apoptosis in human prostate adenocarcinoma cells.

Abstract：

:Although it has been shown that calpains may play a positive role in causing apoptosis of T cells, we report here that, on the contrary, the inhibition of calpain-like activities can induce apoptosis in human prostate cancer cells. Two calpain inhibitors were used to test growth response on prostate cancer cells and showed remarkable cytotoxicity. The cytotoxicity was due to apoptosis as judged by large genomic DNA fragmentation, chromatin condensation and nuclear fragmentation. Furthermore, using gel band shift assays we have demonstrated that calpain inhibitor 1 causes a prolonged elevation of AP-1 protein activity in human prostate cancer cells. The elevation of AP-1 activity appears to be specific, because calpain inhibitor 1 only stimulates AP-1 but not AP-2 and SP-1 activities. We postulate that the sustained increase in AP-1 activity may be involved in apoptosis induced in prostate cells by calpain inhibitors. Our study thus suggests that calpain-like activity may be a potentially therapeutic target for cancer.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Zhu W,Murtha PE,Young CY

doi

10.1006/bbrc.1995.2403

subject

Has Abstract

pub_date

1995-09-25 00:00:00

pages

1130-7

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(85)72403-5

journal_volume

214

pub_type

杂志文章

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