Dynamic changes in HCN2, HCN4, KCNE1, and KCNE2 expression in ventricular cells from acute myocardial infarction rat hearts.

abstract：:We have studied the functional properties of an alternately spliced form of sheep testicular FSH receptor cDNA that codes for a protein similar to a previously described active receptor but differs in the carboxy terminus in sequence and is also shorter by 25 residues. The receptor expressed in HEK 293 cells fails to ...

journal_title：Biochemical and biophysical research communications

authors： Sairam MR,Jiang LG,Yarney TA,Khan H

更新日期：1996-09-24 00:00:00

abstract：:The ability of a myeloid leukemia cell line (HL-60) to undergo membrane electrical potential changes was followed during neutrophilic differentiation induced by 2 compounds. Membrane-potential changes were induced with 12-O-tetradecanoylphorbol 13-acetate (TPA) or formyl-methionyl-leucyl-phenylalanine (FMLP) and were ...

journal_title：Biochemical and biophysical research communications

authors： Brown GE,Fischkoff SA,Ordonez JV

更新日期：1984-09-28 00:00:00

abstract：:Ras can become activated via multiple distinct receptors in T lymphocytes. However, mechanistic studies of Ras signaling in normal T cells have been hampered by the lack of an efficient technology for gene transfer into resting post-thymic cells. We have overcome this limitation by utilizing adenoviral transduction of...

journal_title：Biochemical and biophysical research communications

authors： Marks RE,Ho AW,Rivas F,Marshall E,Janardhan S,Gajewski TF

更新日期：2003-12-19 00:00:00

abstract：:Bone marrow mesenchymal stem cells (BMMSCs) are pluripotent stem cells, and the osteogenic differentiation of BMMSCs has been drawing attention for a long time. Bone formation is regulated by numerous molecular and cellular signaling pathways, and the differentiation of BMMSCs is controlled by a well-defined genetic p...

journal_title：Biochemical and biophysical research communications

authors： Li X,Guo L,Liu Y,Su Y,Xie Y,Du J,Zhou J,Ding G,Wang H,Bai Y,Liu Y

更新日期：2017-11-18 00:00:00

abstract：:It was previously shown that rhodanese, inactivated with hydrogen peroxide, could only be reactivated in the presence of a reductant or the substrate thiosulfate if these reagents were added soon after inactivation and if the oxidant was removed. Here, we report on the facilitated reactivation (75%) of hydrogen peroxi...

journal_title：Biochemical and biophysical research communications

authors： Del Fierro D,Zardeneta G,Mendoza JA

更新日期：2000-08-02 00:00:00

abstract：:A murine genomic clone of about 16 kilobases encompassing putatively entire bone morphogenetic protein (BMP)-4 gene has been isolated. Comparison with the cDNA clones revealed the existence of at least five exons on the 3' side of the clone. There are two alternative transcriptional start sites, one is for the first e...

journal_title：Biochemical and biophysical research communications

authors： Kurihara T,Kitamura K,Takaoka K,Nakazato H

更新日期：1993-05-14 00:00:00

abstract：:Our previous study on the dynamic transcriptomes activated during human erythropoiesis suggested that transcription factor forkhead box O3 (FOXO3) possibly plays a role in erythroid differentiation. Functional studies in human cell line TF-1 indicated that FOXO3 knockdown repressed erythropoietin (EPO)-induced erythro...

journal_title：Biochemical and biophysical research communications

authors： Wang H,Li Y,Wang S,Zhang Q,Zheng J,Yang Y,Qi H,Qu H,Zhang Z,Liu F,Fang X

更新日期：2015-05-15 00:00:00

abstract：:AmB is an antifungal drug of polyene. Although it is prone to nephrotoxicity, it is still the gold standard in the clinical treatment of fungal infection. Sterol plays a decisive role in the drug activity of AmB. The antifungal activity of AmB depends on ergosterol in fungal membranes, and its toxicity is related to c...

journal_title：Biochemical and biophysical research communications

authors： Wang J,Ma Y,Hou S

更新日期：2020-01-15 00:00:00

abstract：:A novel neuropeptide which stimulates adenylate cyclase in rat anterior pituitary cell cultures was isolated from ovine hypothalamic tissues. Its amino acid sequence was revealed as: His-Ser-Asp-Gly-Ile-Phe-Thr-Asp-Ser-Tyr-Ser-Arg-Tyr-Arg-Lys-Gln- Met-Ala- Val-Lys-Lys-Tyr-Leu-Ala-Ala-Val-Leu-Gly-Lys-Arg-Tyr-Lys-Gln-Ar...

journal_title：Biochemical and biophysical research communications

authors： Miyata A,Arimura A,Dahl RR,Minamino N,Uehara A,Jiang L,Culler MD,Coy DH

更新日期：1989-10-16 00:00:00

abstract：:Neutrophil discharge of calcium into the ambient medium was measured, using an ion-sensitive electrode, after cells were stimulated with phorbol myristate acetate. Dose-dependent calcium efflux was observed over the same range of stimulus concentrations associated with specific granule marker release. Calcium efflux w...

journal_title：Biochemical and biophysical research communications

authors： Styrt B,Schwartz MA,Klempner MS

更新日期：1988-08-15 00:00:00

abstract：:As vectors, adenoviruses (Ads) have many attractive advantages for in vivo gene therapy. However, Ads do not usually integrate into the host genome and gene expression is, thus, transient. Adeno-associated virus (AAV) integrates into a specific locus (AAVS1) on the human host's chromosome 19, while conventional recomb...

journal_title：Biochemical and biophysical research communications

authors： Ueno T,Matsumura H,Tanaka K,Iwasaki T,Ueno M,Fujinaga K,Asada K,Kato I

更新日期：2000-07-05 00:00:00

abstract：:BMP-3b (also called GDF-10) is a novel BMP-3-related protein recently discovered in rat femur tissue. Gene expression of BMP-3b in osteoblastic cells and its regulation by prolonged culture, BMP-2 and transforming growth factor beta1 (TGF-beta1) were examined. The BMP-3b gene was highly expressed in rat osteoblasts ob...

journal_title：Biochemical and biophysical research communications

authors： Hino J,Matsuo H,Kangawa K

更新日期：1999-03-16 00:00:00

abstract：:Diacylglycerol kinase (DGK) plays an important role in phosphoinositide signaling cascade by regulating the intracellular level of diacylglycerol and phosphatidic acid. The DGK family is involved in various pathophysiological responses that are mediated through unique binding partners in different tissues and cells. I...

journal_title：Biochemical and biophysical research communications

authors： Okada M,Hozumi Y,Iwazaki K,Misaki K,Yanagida M,Araki Y,Watanabe T,Yagisawa H,Topham MK,Kaibuchi K,Goto K

更新日期：2012-04-06 00:00:00

abstract：:We previously reported synergistic induction of apoptosis by IFN-gamma plus either cyclosporin A (CsA) or tacrolimus (FK506) in gastric carcinoma cells. In this study, we aimed to elucidate the mechanism for this synergistic induction of apoptosis. IFN-gamma plus CsA synergistically induced caspase-3 mediated apoptosi...

journal_title：Biochemical and biophysical research communications

authors： Beppu K,Morisaki T,Matsunaga H,Uchiyama A,Ihara E,Hirano K,Kanaide H,Tanaka M,Katano M

更新日期：2003-06-13 00:00:00

abstract：:We previously found a new endogenous factor in rat liver cytosol, named ATP-stimulated glucocorticoid-receptor translocation promoter (ASTP), that increased the binding of activated glucocorticoid-receptor to nuclei in the presence of ATP. We have cloned and sequenced a cDNA (2989 bp) encoding the ASTP protein. An ope...

journal_title：Biochemical and biophysical research communications

authors： Okamoto K,Hirano H,Isohashi F

更新日期：1993-06-30 00:00:00

abstract：:SND p102 is a rat liver endoplasmic reticulum cholesterol ester hydrolase recently described as a member of a conserved family of transcriptional coactivators that promotes phospholipid secretion into lipoproteins when overexpressed in hepatocytes. In this work, we report first evidence for a mechanism of transcriptio...

journal_title：Biochemical and biophysical research communications

authors： Rodríguez L,Ochoa B,Martínez MJ

更新日期：2007-04-27 00:00:00

abstract：:An inhibitor against the egg beta-D-N-acetylglucosaminidase (GlcNAcase) was purified from the vitelline coat of eggs of the ascidian, Halocynthia roretzi. The purified inhibitor gave a single band with an apparent molecular mass of 70 kDa on SDS-PAGE under non-reducing conditions. The GlcNAcase inhibitor potently inhi...

journal_title：Biochemical and biophysical research communications

authors： Matsuura K,Sawada H,Yokosawa H

更新日期：1995-08-04 00:00:00

abstract：:Both the epidermal growth factor receptor (EGFR) and type 1 insulin-like growth factor receptor (IGF1R) require homo- and hetero-dimerisation with their own family members to acquire full function. We recently showed that IGF1R gene silencing led to EGFR hyper-phosphorylation in human breast cancer cells, and hypothes...

journal_title：Biochemical and biophysical research communications

authors： Riedemann J,Takiguchi M,Sohail M,Macaulay VM

更新日期：2007-04-13 00:00:00

abstract：:Hypoxia-inducible factors are crucial in the regulatory process of oxygen homeostasis of vertebrate cells. Inhibition of prolyl hydroxylation of HIF-alpha subunits by prolyl-hydroxylases (PHD1, PHD2 and PHD3) leads to transcription of a greater number of hypoxia responsive genes. We have investigated the subcellular d...

journal_title：Biochemical and biophysical research communications

authors： Steinhoff A,Pientka FK,Möckel S,Kettelhake A,Hartmann E,Köhler M,Depping R

更新日期：2009-10-02 00:00:00

abstract：:MET, also known as hepatocyte growth factor receptor (HGFR), is a receptor tyrosine kinase with an important role, both in normal cellular function as well as in oncogenesis. In many cancer types, abnormal activation of MET is related to poor prognosis and various strategies to inhibit its function, including small mo...

journal_title：Biochemical and biophysical research communications

authors： Humbert M,Medová M,Aebersold DM,Blaukat A,Bladt F,Fey MF,Zimmer Y,Tschan MP

更新日期：2013-02-08 00:00:00

abstract：:Methanol dehydrogenase is a heterotetrameric enzyme containing the prosthetic group pyrroloquinoline quinone (PQQ), which catalyzes the oxidation of methanol to formaldehyde. The crystal structure of methanol dehydrogenase from Methylophilus W3A1, previously determined at high resolution, exhibits a non-planar configu...

journal_title：Biochemical and biophysical research communications

authors： Li J,Gan JH,Mathews FS,Xia ZX

更新日期：2011-03-25 00:00:00

abstract：:Mutation of the Patched gene has been detected in human inherited basal cell nevus syndrome (BCNS) and sporadic basal cell carcinomas (BCC), suggesting a strong relation between a Sonic hedgehog-Patched signal and cell proliferation. In the present study, we demonstrate that Sonic hedgehog is expressed in human lung s...

journal_title：Biochemical and biophysical research communications

authors： Fujita E,Khoroku Y,Urase K,Tsukahara T,Momoi MY,Kumagai H,Takemura T,Kuroki T,Momoi T

更新日期：1997-09-18 00:00:00

abstract：:Ornithine decarboxylase (ODC), which catalyzes polyamine biosynthesis, plays an essential role in cell growth. DL-alpha-Difluoromethylornithine (DFMO), a synthetic inhibitor of ODC, inhibits cell growth. However, the exact mechanism by which polyamine depletion by DFMO results in growth inhibition remains to be elucid...

journal_title：Biochemical and biophysical research communications

authors： Nemoto T,Kamei S,Seyama Y,Kubota S

更新日期：2001-01-26 00:00:00

abstract：:Recent efforts have underlined the role of Serine/Threonine Protein Kinases (STPKs) in growth, pathogenesis and cell wall metabolism in mycobacteria. Herein, we demonstrated that the Mycobacterium tuberculosis EthR, a transcriptional repressor that regulates the activation process of the antitubercular drug ethionamid...

journal_title：Biochemical and biophysical research communications

authors： Leiba J,Carrère-Kremer S,Blondiaux N,Dimala MM,Wohlkönig A,Baulard A,Kremer L,Molle V

更新日期：2014-04-18 00:00:00

abstract：:Apigenin, a plant flavonoid, induced the reversion of transformed phenotypes of v-H-ras-transformed NIH 3T3 cells at a quite low concentration of 12.5 microM. In the present study, we have examined the components of this Ras-mediated signaling transduction to determine whether they were involved in the apigenin-induce...

journal_title：Biochemical and biophysical research communications

authors： Kuo ML,Yang NC

更新日期：1995-07-26 00:00:00

abstract：:Low voltage-activated, rapidly inactivating T-type Ca(2+) channels are found in a variety of cells where they regulate electrical activity and Ca(2+) entry. In whole-cell patch clamp recordings from bovine adrenal zona fasciculata cells, cis-polyunsaturated omega-3 fatty acids including docosahexaenoic acid (DHA), eic...

journal_title：Biochemical and biophysical research communications

authors： Danthi SJ,Enyeart JA,Enyeart JJ

更新日期：2005-02-11 00:00:00

abstract：:Insulin degrading enzyme (IDE) is a thiol-dependent metalloendoprotease that is responsible for initiation of cellular insulin degradation. However, its exact mode of action and the factors controlling it are poorly understood. Since IDE is a metal requiring enzyme, we have examined which metal(s) is(are) endogenously...

journal_title：Biochemical and biophysical research communications

authors： Ebrahim A,Hamel FG,Bennett RG,Duckworth WC

更新日期：1991-12-31 00:00:00

abstract：:Suppressor of cytokine signaling (SOCS) 1 was initially identified as an intracellular negative feedback regulator of the JAK-STAT signal pathway. Recently, it has been suggested that SOCS1 affects signals of growth factors and hormones. One of them, SOCS1, is also known to be involved in auto-regulation of IRS-1-medi...

journal_title：Biochemical and biophysical research communications

authors： Inaba M,Saito H,Fujimoto M,Sumitani S,Ohkawara T,Tanaka T,Kouhara H,Kasayama S,Kawase I,Kishimoto T,Naka T

更新日期：2005-03-25 00:00:00

abstract：:In this report we present evidence that a guanine nucleotide regulatory protein, Gi, mediates opiate action in the rat brain striatum. Opiates inhibit basal adenylate cyclase activity in rat brain striatum. This effect on adenylate cyclase is dose-dependently attenuated by pretreatment of membranes with pertussis toxi...

journal_title：Biochemical and biophysical research communications

authors： Abood ME,Law PY,Loh HH

更新日期：1985-03-15 00:00:00

abstract：:Receptors for atrial natriuretic peptide (ANP) are heterogeneous: an approximately 140-kDa receptor exhibits ANP-stimulated guanylate cyclase activity whereas an approximately 65-kDa receptor is thought to act only as a clearance-storage protein. We have used photoaffinity labeling techniques to show that the human ce...

journal_title：Biochemical and biophysical research communications

authors： Watt VM,Yip CC

更新日期：1989-10-31 00:00:00