Expression of tenascin in the developing human small intestine.

abstract：:Dysfunction of Girdin plays a crucial role in the development of a variety of tumors. Phosphorylated regulation of Girdin has been studied extensively. However, how Girdin is dephosphorylated remains unclear. In this study, we report a mechanism of Girdin dephosphorylation and the importance of this mechanism in the m...

journal_title：Biochemical and biophysical research communications

authors： Li J,Enomoto A,Weng L,Sun L,Takahashi M

更新日期：2019-05-21 00:00:00

abstract：:Tubulointerstitial nephritis antigen (TIN-ag) is an extracellular matrix basement protein which was originally identified as a target antigen involved in anti-tubular basement membrane (TBM) antibody-mediated interstitial nephritis (TIN). Further investigations elucidated that TIN-ag plays a role in renal tubulogenesi...

journal_title：Biochemical and biophysical research communications

authors： Ikeda M,Takemura T,Hino S,Yoshioka K

更新日期：2000-02-05 00:00:00

abstract：:Vinca alkaloids are among a number of cytotoxic agents which target tumor cell microtubules. Studies described herein document the basis for one form of acquired resistance to these plant alkaloids involving an alteration of tubulin in a variant (DC-3F/VCRd-5L) of DC-3F Chinese hamster cells. Our results revealed a ma...

journal_title：Biochemical and biophysical research communications

authors： Sirotnak FM,Danenberg KD,Chen J,Fritz F,Danenberg PV

更新日期：2000-03-05 00:00:00

abstract：:Mouse thymocytes were separated into cortical and medullary subpopulations by differential agglutination with peanut agglutinin. A high-affinity receptor for 1,25-dihydroxyvitamin D3 is present in medullary immunocompetent mouse thymocytes and is absent from cortical immature cells. 1,25-dihydroxyvitamin D3, at physio...

journal_title：Biochemical and biophysical research communications

authors： Ravid A,Koren R,Novogrodsky A,Liberman UA

更新日期：1984-08-30 00:00:00

abstract：:Prior to the binding of peptide in the endoplasmic reticulum (ER), the major histocompatibility complex (MHC) class I heavy chain associates with an assembly complex that includes the transporter associated with antigen processing (TAP). The proximity of a part of the MHC class I alpha2 domain alpha-helix to areas pre...

journal_title：Biochemical and biophysical research communications

authors： Turnquist HR,Vargas SE,Solheim JC

更新日期：2001-12-14 00:00:00

abstract：:Ornithine transcarbamylase activity and immunoreactive enzyme level are compared during perinatal period and in adult rat. Ornithine transcarbamylase activity regularly rises during late fetal period and presents a marked increase 24 hours after birth. Immunoreactive enzyme level does not correlate with this developme...

journal_title：Biochemical and biophysical research communications

authors： Belbekouche M,Gautier C,Vaillant R

更新日期：1985-06-28 00:00:00

abstract：:Endothelial dysfunctions, such as pyroptosis, are chronic inflammatory processes with important roles in atherosclerosis. Adiponectin (APN), an adipocyte-derived protein that is abundant in circulation, reportedly protects against atherosclerosis. However, the mechanism underlying its antiatherogenic effect on human a...

journal_title：Biochemical and biophysical research communications

authors： Zhang L,Yuan M,Zhang L,Wu B,Sun X

更新日期：2019-06-18 00:00:00

abstract：:The molecular mechanisms underlying ultrasound-induced apoptosis remain poorly understood. We have demonstrated that in Jurkat cells, the over-expression of the anti-apoptotic protein Bcl-2 inhibited ultrasound-induced apoptosis, but not necrosis. Inhibition of caspase activity also protected the cells from apoptosis,...

journal_title：Biochemical and biophysical research communications

authors： Kinoshita M,Eguchi Y,Hynynen K

更新日期：2007-02-09 00:00:00

abstract：:Chemotaxis of rabbit peritoneal leucocytes stimulated by fMet-Leu-Phe, a synthetic chemoattractant, was inhibited by Glu-Glu-Glu-Glu-Tyr-Pro-Met-Glu (MT peptide) and Leu-Ile-Glu-Asp-Asn-Glu-Tyr-Thr-Ala-Arg-Glu-Gly (Src peptide). Both peptides did not inhibit the binding of [3H] formyl-NLe-Leu-Phe, a chemoattractant, t...

journal_title：Biochemical and biophysical research communications

authors： Hirata F,Notsu Y,Matsuda K,Vasanthakumar G,Schiffmann E,Wong TW,Goldberg AR

更新日期：1984-01-30 00:00:00

abstract：:One important criteria for a plasma circulating hemoglobin blood substitute is resistance to subunit dissociation. For this reason, cross-linked hemoglobins (with low oxygen affinities) are being specifically designed to serve as potential blood substitutes. An example is HbXL99 alpha, cross-linked between the alpha-s...

journal_title：Biochemical and biophysical research communications

authors： Hirsch RE,Friedman JM,Harrington JR,Scarlata SF,Harrington JP

更新日期：1994-05-16 00:00:00

abstract：:Parkinson's disease (PD) is neurodegenerative disease, featured by a loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc), characteristic motor symptoms and cognitive impairment. Development of effective therapeutic drugs for PD is necessary. In this study, we investigated the potential of Brucein...

journal_title：Biochemical and biophysical research communications

authors： Yang Y,Kong F,Ding Q,Cai Y,Hao Y,Tang B

更新日期：2020-06-11 00:00:00

abstract：:The apical ectodermal ridge (AER) controls limb outgrowth and patterning, such that its removal causes changes in mesodermal gene expression, cell death and limb truncation. Fibroblast growth factor (FGF) family members are expressed in the AER and can rescue limb bud outgrowth after AER removal. Cells localized under...

journal_title：Biochemical and biophysical research communications

authors： Pascoal S,Andrade RP,Bajanca F,Palmeirim I

更新日期：2007-01-05 00:00:00

abstract：:We have compared the coupling of human alpha(1A)-, alpha(1B)-, and alpha(1D)-adrenoceptors (expressed at approximately 2000 fmol/mg protein in Chinese hamster ovary cells) to cellular growth promotion (as assessed by [(3)H]thymidine incorporation) and related signaling mechanisms. Maximum elevation of intracellular Ca...

journal_title：Biochemical and biophysical research communications

authors： Keffel S,Alexandrov A,Goepel M,Michel MC

更新日期：2000-06-16 00:00:00

abstract：:In the previous study (Sato K.-I. et al. (1997) FEBS Lett. 410, 136-140), we showed that the phosphorylation of Shc protein by c-Src is dependent on the binding of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) to the PTB domain of Shc. In this study, we demonstrate that, in contrast to c-Src, v-Src and epiderm...

journal_title：Biochemical and biophysical research communications

authors： Sato K,Gotoh N,Otsuki T,Kakumoto M,Aoto M,Tokmakov AA,Shibuya M,Fukami Y

更新日期：1997-11-17 00:00:00

abstract：:Complementary DNA corresponding to total poly(A)+-RNA from the human A431 epidermoid carcinoma cell line was cloned in the phage expression vector lambda gt 11. An epidermal growth factor (EGF) receptor cDNA clone was obtained by screening of the expression library with a rabbit polyclonal antibody (IgG), raised to th...

journal_title：Biochemical and biophysical research communications

authors： Simmen FA,Gope ML,Schulz TZ,Wright DA,Carpenter G,O'Malley BW

更新日期：1984-10-15 00:00:00

abstract：:The MCF-7 human breast cancer cell line is routinely used as a model system for the study of ER+, estrogen-responsive human breast cancer. Although most investigators have found these cells to be estrogen-responsive, there are reports that some stocks of MCF-7 cells may be either insensitive or may display decreased s...

journal_title：Biochemical and biophysical research communications

authors： Klotz DM,Castles CG,Fuqua SA,Spriggs LL,Hill SM

更新日期：1995-05-16 00:00:00

abstract：:The objective of the present study is to demonstrate that a newly developed selective c-Fos/activator protein (AP)-1 inhibitor, T-5224, inhibits the expression of matrix metalloproteinases (MMPs) in human articular chondrocytes, and prevents cartilage destruction in an osteoarthritis (OA)-induced mouse model. First, w...

journal_title：Biochemical and biophysical research communications

authors： Motomura H,Seki S,Shiozawa S,Aikawa Y,Nogami M,Kimura T

更新日期：2018-03-04 00:00:00

abstract：:AHNAK is a giant protein of approximately 700 kDa identified in human neuroblastomas and skin epithelial cells. Recently, we found that AHNAK knock-out (AHNAK(-/-)) mice have a strong resistance to high-fat diet-induced obesity. In this study, we applied (1)H NMR-based metabolomics with multivariate statistical analys...

journal_title：Biochemical and biophysical research communications

authors： Kim IY,Jung J,Jang M,Ahn YG,Shin JH,Choi JW,Sohn MR,Shin SM,Kang DG,Lee HS,Bae YS,Ryu DH,Seong JK,Hwang GS

更新日期：2010-12-17 00:00:00

abstract：:Proteins modified by oxidants are rapidly degraded by intracellular proteases. Oxidatively modified superoxide dismutase (Ox-SOD) was degraded 2-8 times faster at both acidic and alkaline pH than the native protein in bovine cardiac tissue extracts. At acidic pH, Ox-SOD hydrolysis was stimulated by ATP and by non-hydr...

journal_title：Biochemical and biophysical research communications

authors： Strack PR,Waxman L,Fagan JM

更新日期：1996-02-15 00:00:00

abstract：:The tumor suppressor, RASSF2 (Ras association domain family 2), is frequently downregulated in a number of cancers. Although exogenously expressed RASSF2 induces apoptotic cell death, the precise roles of RASSF2 under pro-apoptotic conditions remain largely unknown. Here, we demonstrate that MST1 (mammalian sterile 20...

journal_title：Biochemical and biophysical research communications

authors： Song H,Oh S,Oh HJ,Lim DS

更新日期：2010-01-01 00:00:00

abstract：:We have developed a rapid and sensitive method for total DNA measurement using single-stranded DNA binding protein from E coli conjugated with horseradish peroxidase or urease. To detect DNA, the sample is heated or alkali treated to denature the DNA and then filtered through nylon or nitrocellulose membranes. After t...

journal_title：Biochemical and biophysical research communications

authors： Sheldon EL 3rd,Nagainis PA,Kung VT

更新日期：1989-11-30 00:00:00

abstract：:The nonapeptide Cys-Tyr-Cys-Gln-Asp-Pro-Tyr-Val-Lys was prepared by solid-phase peptide synthesis under oxidizing conditions. Fast atom bombardment mass spectrometric analysis of the untreated molecule produced an ion consistent with a structure involving an intramolecular disulfide bond between Cys(1) and Cys(3). Mas...

journal_title：Biochemical and biophysical research communications

authors： Pramanik B,Tsarbopoulos A,Labdon JE,Czarniecki M,Nagabhushan TL,Trotta PP

更新日期：1988-12-15 00:00:00

abstract：:BHLHB2/DEC1 is a transcription factor implicated in cell proliferation, apoptosis, and metabolism, and is also known to play an important role in the regulation of the mammalian circadian rhythm. However, its precise role in metabolism remains unclear. We investigated the link between BHLHB2 and ChREBP, a glucose-acti...

journal_title：Biochemical and biophysical research communications

authors： Iizuka K,Horikawa Y

更新日期：2008-09-12 00:00:00

abstract：:The TOR pathway is a kinase signaling pathway that regulates cellular growth and proliferation in response to nutrients and growth factors. TOR signaling is also important in lifespan regulation - when this pathway is inhibited, either naturally, by genetic mutation, or by pharmacological means, lifespan is extended. ...

journal_title：Biochemical and biophysical research communications

authors： Khan MH,Hart MJ,Rea SL

更新日期：2012-08-24 00:00:00

abstract：:We investigated the role of Toll-like receptor 4 (TLR4), a major mediator of innate immune responses, on cognitive performance in a type 1 diabetes model (T1D). After administration of streptozotocin, both TLR4 knockout (TLR4 KO) and wild type (WT) diabetic mice displayed metabolic alterations similar to those observe...

journal_title：Biochemical and biophysical research communications

authors： Kawamoto EM,Cutler RG,Rothman SM,Mattson MP,Camandola S

更新日期：2014-01-10 00:00:00

abstract：:The physiologically active form of vitamin D, 1,25-dihydroxyvitamin D(3), plays an important role not only in the establishment and maintenance of calcium metabolism, but also in regulating cell growth and differentiation. Because the clinical usefulness of 1,25-dihydroxyvitamin D(3) is limited by its tendency to caus...

journal_title：Biochemical and biophysical research communications

authors： Gaschott T,Steinmeyer A,Steinhilber D,Stein J

更新日期：2002-01-11 00:00:00

abstract：:Brain cell-free extract greatly stimulates the polymerization rate of purified tubulin with a reduction of the nucleation period and without a significant alteration of the final assembly state. This effect is mimicked by neuroblastoma extract at 10-fold lower extract concentration, but not by excess muscle extract. C...

journal_title：Biochemical and biophysical research communications

authors： Liliom K,Wágner G,Kovács J,Comin B,Cascante M,Orosz F,Ovádi J

更新日期：1999-10-22 00:00:00

abstract：:Gastrin heptadecapeptides (gastrins I and II which differ in the presence of sulfate on the tyrosine of the latter) have been purified and sequenced from several mammalian species including pig, dog, cat, sheep, cow, human and rat. A 34 amino acid precursor ("big" gastrin), generally accounting for only 5% of total ga...

journal_title：Biochemical and biophysical research communications

authors： Shinomura Y,Eng J,Yalow RS

更新日期：1987-02-27 00:00:00

abstract：:Pancreatic ductal carcinoma (PDC) remains one of the most intractable human malignancies. To obtain insight into the molecular pathogenesis of PDC, we constructed a retroviral cDNA expression library with total RNA isolated from the PDC cell line MiaPaCa-2. Screening of this library with the use of a focus formation a...

journal_title：Biochemical and biophysical research communications

authors： Fujiwara S,Yamashita Y,Choi YL,Wada T,Kaneda R,Takada S,Maruyama Y,Ozawa K,Mano H

更新日期：2005-12-16 00:00:00

abstract：:Chronic elevated glucose is harmful to pancreatic β-cells, resulting in pancreatic β-cells dysfunction and apoptosis. Understanding the molecular mechanisms associated with β-cells survival is pivotal for the prevention of β-cells injury caused by glucotoxicity. The role of Phosphatase and tensin homologue (PTEN)-indu...

journal_title：Biochemical and biophysical research communications

authors： Zhang J,Chen K,Wang L,Wan X,Shrestha C,Zhou J,Mo Z

更新日期：2016-08-05 00:00:00