Characterization of an alveolyn-like protein associated with mouse type 2 pneumocytes using immunochemical methods.

Abstract:

:Delipidated proteins from a fraction of mouse lung homogenate enriched for lamellar bodies of type 2 pneumocytes were characterized by a combination of gel filtration and enzyme immunoassay for the presence of a surfactant-associated antigen. Immunoreactivity was associated with a protein of Mr 250-270,000 as well as its multimers and proteolytic fragments. The characteristics of the antigenic protein closely resembled those of a surfactant-associated protein termed alveolyn which is reported to be secreted by type 2 pneumocytes of various other species. Surfactant-associated proteins of M 32-38,000 in bronchoalveolar lavage fluid may be derived from this molecule by proteolysis.

authors

Kumar RK,Smith GJ,Truscott JY,Hristoforidis CP,Lykke AW

subject

Has Abstract

pub_date

1986-09-30 00:00:00

pages

1135-41

issue

3

eissn

0006-291X

issn

1090-2104

journal_volume

139

pub_type

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