MIDA1, an Id-associating protein, has two distinct DNA binding activities that are converted by the association with Id1: a novel function of Id protein.

abstract：:Effect of recombinant human interleukin-11 (rhIL-11) on the expression of transcripts encoding microsomal heme oxygenase (HO), the rate-limiting enzyme in heme catabolism, and haptoglobin (Hpt), a major acute-phase protein, were examined in human HepG2 hepatoma cells. Treatment of HepG2 cells with rhIL-11 elicited an ...

journal_title：Biochemical and biophysical research communications

authors： Fukuda Y,Sassa S

更新日期：1993-05-28 00:00:00

abstract：:Substrate-binding proteins (SBPs) bind to specific ligands and are associated with membrane protein complexes for transport or signal transduction. Most SBPs recognize substrates by the hinge motion between two distinct α/β domains. However, short SBP motifs are often observed in protein databases, which are located a...

journal_title：Biochemical and biophysical research communications

authors： Bae JE,Kim IJ,Kim KJ,Nam KH

更新日期：2018-02-26 00:00:00

abstract：:Proteolipid protein, the major protein component of central nervous system (CNS) myelin, is known to contain approximately 2% by weight of covalently bound fatty acids. Recently, this protein was also found, though at a lower concentration, in the peripheral nervous system (PNS). The present study was undertaken to de...

journal_title：Biochemical and biophysical research communications

authors： Tetzloff SU,Bizzozero OA

更新日期：1993-06-30 00:00:00

abstract：:Thyroglobulin of very low iodine content has been prepared from a single non-toxic human goitre. The initial iodine content of the protein (0.038%) has been increased to levels of 0.16% and 0.85% by in vitro treatment with thyroid peroxidase and the resulting proteins studied with respect to their intrinsic fluorescen...

journal_title：Biochemical and biophysical research communications

authors： Zabel KM,Rawitch AB

更新日期：1984-05-31 00:00:00

abstract：:The subunit arrangement of wheat germ RNA polymerase II was examined using the cleavable cross-linking reagent dithiobis(succinimidyl propionate). Conditions were chosen such that the enzyme was active prior to treatment, and that most of the subunits were reactive towards the reagent. Our results indicate that the en...

journal_title：Biochemical and biophysical research communications

authors： Bateman E,Nicholson BH

更新日期：1984-06-15 00:00:00

abstract：:Thrombo-occlusive diseases are major causes of morbidity and mortality, and tissue-type plasminogen activator (t-PA) is recommended for the treatment of the maladies. However, both t-PA and u-PA are rapidly inactivated by plasminogen activator inhibitor-1 (PAI-1). Here, we show that longistatin, a novel plasminogen ac...

journal_title：Biochemical and biophysical research communications

authors： Anisuzzaman,Khyrul Islam M,Abdul Alim M,Miyoshi T,Hatta T,Yamaji K,Matsumoto Y,Fujisaki K,Tsuji N

更新日期：2011-10-07 00:00:00

abstract：:The human EBAG9 was previously identified as an estrogen responsive gene using CpG-genomic binding site cloning (Watanate et al., (1998) Mol. Cell. Biol. 18: 442-449). Recently it was revealed that the EBAG9 is identical with RCAS1 which is a cancer cell surface antigen implicated in immune escape. Here, we isolated a...

journal_title：Biochemical and biophysical research communications

authors： Ikeda K,Sato M,Tsutsumi O,Tsuchiya F,Tsuneizumi M,Emi M,Imoto I,Inazawa J,Muramatsu M,Inoue S

更新日期：2000-07-05 00:00:00

abstract：:Using antibodies to the procollagen C-proteinase enhancer of mouse fibroblast culture medium, we have screened by immunoblotting extracts of several post natal mouse and rat tissues for the presence of the enhancer antigen. All rodent connective tissues were relatively rich in enhancer; lower amounts were found in ske...

journal_title：Biochemical and biophysical research communications

authors： Kessler E,Mould AP,Hulmes DJ

更新日期：1990-11-30 00:00:00

abstract：:Flavivirus non-structural protein 4A (NS4A) induces membrane rearrangements to form viral replication complex and functions as interferon antagonist. However, other non-structural roles of NS4A protein in relation to virus life-cycle are poorly defined. This study elucidated if dengue virus (DENV) NS4A protein interac...

journal_title：Biochemical and biophysical research communications

authors： Jiang L,Yao H,Duan X,Lu X,Liu Y

更新日期：2009-07-24 00:00:00

abstract：:Human myogenic cells have limited ability to proliferate in culture. Although forced expression of telomerase can immortalize some cell types, telomerase alone delays senescence of human primary cultured myogenic cells, but fails to immortalize them. In contrast, constitutive expression of both telomerase and the E7 g...

journal_title：Biochemical and biophysical research communications

authors： Hashimoto N,Kiyono T,Wada MR,Shimizu S,Yasumoto S,Inagawa M

更新日期：2006-10-06 00:00:00

abstract：:Salvianolic acid A (Sal A) is a polyphenol extracted from the root of the Salvia miltiorrhiza bunge. Hydrogen peroxide (H(2)O(2)) is a major reactive oxygen species (ROS), which has been implicated in stroke and other neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. In this study, we ...

journal_title：Biochemical and biophysical research communications

authors： Zhang HA,Gao M,Zhang L,Zhao Y,Shi LL,Chen BN,Wang YH,Wang SB,Du GH

更新日期：2012-05-11 00:00:00

abstract：:We have cloned the 5' upstream -1034 to +88 fragment of the human inducible nitric oxide synthase (hiNOS) gene and demonstrate its competence to promote luciferase gene transcription in vascular-smooth-muscle (VSM) cells and macrophages. Sequential 5' end-deletions localized positive regulatory elements of hiNOS trans...

journal_title：Biochemical and biophysical research communications

authors： Kolyada AY,Savikovsky N,Madias NE

更新日期：1996-03-27 00:00:00

abstract：:Rats were fed for 15 days a diet containing ammonium acetate (20% w/w) and then injected i. p. with ammonium acetate (7 mmol/Kg). Only 1 out of 18 control rats but 9 of 18 rats fed ammonium survived, indicating a protective effect of ammonium ingestion against an acute ammonia challenge. Blood ammonia returned to norm...

journal_title：Biochemical and biophysical research communications

authors： Miñana MD,Felipo V,Grisolía S

更新日期：1988-06-30 00:00:00

abstract：:Age-related hearing loss (ARHL) is a neurodegenerative disease associated with an aged population. ARHL is influenced by biological factors such as aging, sex difference, and atherosclerosis. The mechanisms of ARHL caused by atherosclerosis have not been previously determined in apolipoprotein E knockout (ApoE KO) mal...

journal_title：Biochemical and biophysical research communications

authors： Kim YY,Chao JR,Kim C,Kim B,Thi-Thanh Nguyen P,Jung H,Chang J,Lee JH,Suh JG

更新日期：2020-03-12 00:00:00

abstract：:Myocardial fibrosis is the pathological consequence of injury-induced fibroblastto-myofibroblast transition, resulting in increased stiffness and diminished cardiac function. Histone modification has been shown to play an important role in the pathogenesis of cardiac fibrosis. Here, we identified H3K27me3 demethylase ...

journal_title：Biochemical and biophysical research communications

authors： Long F,Wang Q,Yang D,Zhu M,Wang J,Zhu Y,Liu X

更新日期：2020-08-06 00:00:00

abstract：:The TOR pathway is a kinase signaling pathway that regulates cellular growth and proliferation in response to nutrients and growth factors. TOR signaling is also important in lifespan regulation - when this pathway is inhibited, either naturally, by genetic mutation, or by pharmacological means, lifespan is extended. ...

journal_title：Biochemical and biophysical research communications

authors： Khan MH,Hart MJ,Rea SL

更新日期：2012-08-24 00:00:00

abstract：:Cycloprodigiosin hydrochloride (cPrG.HCl), a member of the prodigiosin family, is a red pigment obtained from the marine bacterium Pseudoalteromonas denitrificans. cPrG.HCl markedly suppressed 3H-thymidine incorporation by concanavalin A stimulated murine splenocytes but had little effect on lipopolysaccharide depende...

journal_title：Biochemical and biophysical research communications

authors： Kawauchi K,Shibutani K,Yagisawa H,Kamata H,Nakatsuji S,Anzai H,Yokoyama Y,Ikegami Y,Moriyama Y,Hirata H

更新日期：1997-08-28 00:00:00

abstract：:The transcription factor hypoxia-inducible factor 1alpha (HIF-1alpha) is regulated by oxygen availability as well as various inflammatory mediators, including tumor necrosis factor alpha (TNFalpha). Early work suggested that the phosphatidylinositol-3-kinase (PI3K) and mitogen-activated protein kinase (MAPK) signaling...

journal_title：Biochemical and biophysical research communications

authors： Kuo HP,Lee DF,Xia W,Wei Y,Hung MC

更新日期：2009-11-27 00:00:00

abstract：:The effect of the mitochondrial dye rhodamine 123 (Rho 123) on protein synthesis (PS) activity was investigated in mitochondria isolated from liver and from both chloroma and erythroleukemia tumors. Incorporation of labelled leucine into mitochondrial protein was used to measure the rate of PS. While PS specific activ...

journal_title：Biochemical and biophysical research communications

authors： Abou-Khalil WH,Arimura GK,Yunis AA,Abou-Khalil S

更新日期：1986-06-13 00:00:00

abstract：:We studied the regulation of glutathione (GSH) synthesis and characterised the 5'-promoter region of the gamma-glutamylcysteine synthetase-heavy subunit (gammaGCS-HS) gene in human alveolar type II cells (A549) following exposure to menadione (MQ) and hydrogen peroxide (H2O2). Both MQ (100 microM) and H2O2 (100 microM...

journal_title：Biochemical and biophysical research communications

authors： Rahman I,Bel A,Mulier B,Lawson MF,Harrison DJ,Macnee W,Smith CA

更新日期：1996-12-24 00:00:00

abstract：:We have investigated the status of the MTS2 gene, encoding the cyclin-dependent kinase (CDK) inhibitor p15, in 32 glioblastomas. Semi-quantitative PCR identified 7 tumors in which the amplified material was 18.6% of controls and 7 in which was 48.0%, suggesting the occurrence of homozygous and hemizygous deletions, re...

journal_title：Biochemical and biophysical research communications

authors： Tenan M,Benedetti S,Finocchiaro G

更新日期：1995-12-05 00:00:00

abstract：:The formation of inactive complexes in excess molar amounts of human cathepsins H and L with their protein inhibitors human stefin A, human stefin B and chicken cystatin at pH 5.6 has been shown by measurement of enzyme activity coupled with reverse-phase HPLC not to involve covalent cleavage of the inhibitors. Inhibi...

journal_title：Biochemical and biophysical research communications

authors： Lenarcic B,Kos J,Dolenc I,Lucovnik P,Krizaj I,Turk V

更新日期：1988-07-29 00:00:00

abstract：:Members of the Rab family of low molecular weight GTP-binding (LMWG) proteins regulate vesicular transport; distinct Rab proteins are located in specific vesicular compartments within the exocytotic and endocytotic pathway. Pancreatic zymogen granules possess multiple LMWG. Rab 3A, however, which has been suggested to...

journal_title：Biochemical and biophysical research communications

authors： Wagner AC,Strowski MZ,Göke B,Williams JA

更新日期：1995-02-27 00:00:00

abstract：:Upon incubation of bovine thyroglobulin with trypsin at high enzyme/substrate ratio, some fragments with apparent masses between 18 and 31 kDa resisted prolonged digestion. Their NH2-terminal sequences were determined. All fragments overlapped with some of the Cys-rich repeats that compose a large part of thyroglobuli...

journal_title：Biochemical and biophysical research communications

authors： Gentile F,Palumbo G

更新日期：1993-11-15 00:00:00

abstract：:To study the hierarchical levels of stem cell targets for ABL-kinase domain mutations in CML, highly purified CD34+CD38- and CD34+CD38+ cell populations and their LTC-IC-derived progeny were analyzed in four patients at diagnosis (n=1) or in advanced phases (n=3) of their disease. In the single patient with early phas...

journal_title：Biochemical and biophysical research communications

authors： Sorel N,Bonnet ML,Guillier M,Guilhot F,Brizard A,Turhan AG

更新日期：2004-10-22 00:00:00

abstract：:Th2 type immune responses are essential for protective immunity against parasites and play crucial roles in allergic disorders. Helminth parasites secrete a variety of proteases for their infectious cycles including for host entry, tissue migration, and suppression of host immune effector cell function. Furthermore, a...

journal_title：Biochemical and biophysical research communications

authors： Nishikado H,Fujimura T,Taka H,Mineki R,Ogawa H,Okumura K,Takai T

更新日期：2015-05-01 00:00:00

abstract：:With the global pandemic of hepatitis B and C infections, the incidence of Hepatocellular carcinoma (HCC) is rapidly increasing world wide. We identified glypican-3 (GPC3), a novel oncofetal gene over-expressed specifically in human HCC, as based on data of cDNA microarrays. As GPC3 is a GPI-anchored membrane protein ...

journal_title：Biochemical and biophysical research communications

authors： Nakatsura T,Yoshitake Y,Senju S,Monji M,Komori H,Motomura Y,Hosaka S,Beppu T,Ishiko T,Kamohara H,Ashihara H,Katagiri T,Furukawa Y,Fujiyama S,Ogawa M,Nakamura Y,Nishimura Y

更新日期：2003-06-20 00:00:00

abstract：:The developing and the adult brain respond in similar ways to ischemia, but also display clear differences. For example, the relative contributions of necrosis and apoptosis to neuronal death may be different, such that apoptotic mechanisms would be more prevalent in the developing brain. During normal development, mo...

journal_title：Biochemical and biophysical research communications

authors： Blomgren K,Zhu C,Hallin U,Hagberg H

更新日期：2003-05-09 00:00:00

abstract：:A complementary DNA clone encoding serum amyloid A protein has been isolated from an acute rabbit liver cDNA library. Complete nucleotide sequence analysis reveals that the cloned gene contains a 24 bases 5' untranslated region, 369 bases coding region and a 106 bases 3' untranslated region. Primer extension analysis ...

journal_title：Biochemical and biophysical research communications

authors： Ray BK,Ray A

更新日期：1991-07-15 00:00:00

abstract：:EGF stimulates gene expression through a variety of signal transduction pathways that include the ras-Erk pathway. We have shown previously that EGF receptor activation stimulates gastrin gene expression through a GC-rich element called gERE. This element binds Sp1 family members and raises the possibility that the ra...

journal_title：Biochemical and biophysical research communications

authors： Merchant JL,Du M,Todisco A

更新日期：1999-01-19 00:00:00