Inhibition of brain hexokinase by a multisubstrate analog results from binding to a discrete regulatory site.

abstract：:Induction of cyclin D1 expression is a critical feature of growth factor-induced cell proliferation in hepatocytes. To clarify the mechanisms regulating cyclin D1 gene expression, we isolated the rat cyclin D1 gene and analyzed the transcriptional regulatory elements in rat hepatoma cells and primary cultured rat hepa...

journal_title：Biochemical and biophysical research communications

authors： Moriuchi A,Ido A,Nagata Y,Nagata K,Uto H,Hasuike S,Hori T,Hirono S,Hayashi K,Tsubouchi H

更新日期：2003-01-10 00:00:00

abstract：:The effects of trace acetylation on the contact sites in peptide-antibody binding have been investigated by using a label selection method. A 13-residue synthetic peptide having three lysines (LKLVEQQNPKVKL) corresponding to sequence position 155-168 of beta 1,4-galactosyltransferase was used in this study. The four a...

journal_title：Biochemical and biophysical research communications

authors： Yadav SP,Rawitch AB

更新日期：1994-12-30 00:00:00

abstract：:Rodent brown adipocytes express peroxisome proliferator activated receptor-alpha (PPARalpha) and PPARgamma and while the rodent uncoupling protein-1 (UCP-1) gene contains a putative peroxisome proliferator response element (PPRE), only PPARgamma activation by thiazolidinediones increase UCP-1 mRNA levels. We have inve...

journal_title：Biochemical and biophysical research communications

authors： Teruel T,Clapham JC,Smith SA

更新日期：1999-10-22 00:00:00

abstract：:Growth cone extension is guided by extracellular factors during the brain development but the underlying cellular mechanisms remain largely unclear. Here, we examined the potential function of class-3 semaphorins in cultured cerebellar granule cells. We found neuropilin-2 (NP2), the high-affinity receptor for semaphor...

journal_title：Biochemical and biophysical research communications

authors： Ding S,Luo JH,Yuan XB

更新日期：2007-05-18 00:00:00

abstract：:Comprehensive knowledge on the murine CT26 colon carcinoma line is a classic model used in the pharmacodynamic experiments involving IDO-1 inhibitors, immune-related checkpoint antibodies and immune related mechanisms. In this study, we determined the impact of different subcutaneous inoculation locations on tumor gro...

journal_title：Biochemical and biophysical research communications

authors： Fu X,Yang Y,Xie J,Pan X,Yang X,Du Z,Hao E

更新日期：2019-04-30 00:00:00

abstract：:Using affinity chromatography on immobilized transcortin of 125I-labeled, cholate-solubilized plasma membranes of human syncytiotrophoblast, a transcortin-binding protein with a minimal Mr of about 20 kDa has been isolated. It was found to be a sialoglycoprotein with an isoelectric point at pH 4.4 (about 5.0 after the...

journal_title：Biochemical and biophysical research communications

authors： Krupenko SA,Avvakumov GV,Strel'chyonok OA

更新日期：1991-06-14 00:00:00

abstract：:Myosin light-chain kinase (MLCK) of smooth muscle consists of an actin-binding domain at the N-terminal, the catalytic domain in the central portion, and the myosin-binding domain at the C-terminal. The kinase activity is mediated by the catalytic domain that phosphorylates the myosin light-chain of 20kDa (MLC20), act...

journal_title：Biochemical and biophysical research communications

authors： Nakamura A,Xie C,Zhang Y,Gao Y,Wang HH,Ye LH,Kishi H,Okagaki T,Yoshiyama S,Hayakawa K,Ishikawa R,Kohama K

更新日期：2008-04-25 00:00:00

abstract：:The reversible reduction and reoxidation of Escherichia coli sulfite reductase hemeprotein subunit at pH 9.9 produces high and low spin ferric species, the latter with properties distinct from any alkaline low spin yet reported. With virtually no effect on the 298 degrees K optical spectrum, chloride drastically reduc...

journal_title：Biochemical and biophysical research communications

authors： Young LJ,Siegel LM

更新日期：1990-05-31 00:00:00

abstract：:In rat pancreatic acinar cells epidermal growth factor (EGF) and insulin increase both basal and cholecystokinin (CCK-OP) stimulated amylase release in vitro (1) as a long term function of this tissue. Here we show that preincubation of isolated plasma membranes with EGF or with insulin leads to increased incorporatio...

journal_title：Biochemical and biophysical research communications

authors： Pröfrock A,Schnefel S,Schulz I

更新日期：1991-03-15 00:00:00

abstract：:CHFR ubiquitin ligase acts as a checkpoint upon DNA damage and its functional inactivation is one of key characteristics of tumor development and metastasis. Despite the crucial role in maintaining genome integrity and cell cycle progression, little is known how CHFR stability is regulated. Here, we showed that CHFR i...

journal_title：Biochemical and biophysical research communications

authors： Kwon YE,Bae SJ,Kim M,Seol JH

更新日期：2013-01-04 00:00:00

abstract：:Human prothrombin kringle-2 and its partial peptide, NSA9 (NSAVQLVEN), have been reported to have potent anti-angiogenic activities. Here, the internalization mechanism of NSA9 into bovine capillary endothelial (BCE) cells was examined using lactate dehydrogenase (LDH) release assay, fluorescence microscopy, and flow ...

journal_title：Biochemical and biophysical research communications

authors： Hwang HS,Kim SS

更新日期：2005-09-23 00:00:00

abstract：:Mycobacterium tuberculosis (TB) small heat shock protein Hsp16.3 was found to be a major membrane protein that is most predominantly expressed under oxidative stress and is localized to the thickened cell envelope. Gene knock-out studies indicate that the Hsp16.3 protein is required for TB to grow in its host macropha...

journal_title：Biochemical and biophysical research communications

authors： Abulimiti A,Qiu X,Chen J,Liu Y,Chang Z

更新日期：2003-05-23 00:00:00

abstract：:L-arginine may aid in the liver detoxification and may benefit in the treatment of liver disorders such as liver injury. The present study was to investigate the possible protective and curative effects of L-arginine on carbon tetrachloride (CCl(4)) induced hepatotoxicity. Mice received a single dose of CCl(4). L-argi...

journal_title：Biochemical and biophysical research communications

authors： Saad EA

更新日期：2012-06-22 00:00:00

abstract：:A body of indirect evidence has suggested the involvement of reactive oxygen species (ROS) in tumor promotion. However, direct evidence for the involvement of in situ generated ROS in tumor promotion is lacking at present. This study provides the first in situ evidence for the involvement of ROS in stage I tumor promo...

journal_title：Biochemical and biophysical research communications

authors： Giri U,Sharma SD,Abdulla M,Athar M

更新日期：1995-04-17 00:00:00

abstract：:To help clarify bases for the molecular weight and surface charge heterogeneities of forms of somatic angiotensin converting enzyme (ACE), we examined for differences in N-glycosylation. ACE preparations purified from human, guinea pig, rat and rabbit tissues were found to be heterogeneous in terms of numbers of N-gly...

journal_title：Biochemical and biophysical research communications

authors： Ripka JE,Ryan JW,Valido FA,Chung AY,Peterson CM,Urry RL

更新日期：1993-10-29 00:00:00

abstract：:Using the garfish olfactory nerve, the time-courses of lateral expansion (swelling) and birefringence changes in nerve fibers have been examined at the site of application of electric current pulses. The effects of various chemical agents on these non-electrical signs of rapid structural changes in the nerve fibers ha...

journal_title：Biochemical and biophysical research communications

authors： Tasaki I,Byrne PM

更新日期：1992-10-30 00:00:00

abstract：:Topoisomerase 1 (TOP1) poisons like camptothecin (CPT) are currently used in cancer chemotherapy but these compounds can have damaging, off-target effects on neurons leading to cognitive, sensory and motor deficits. To understand the molecular basis for the enhanced sensitivity of neurons to CPT, we examined the effec...

journal_title：Biochemical and biophysical research communications

authors： Rossi SL,Lumpkin CJ,Harris AW,Holbrook J,Gentillon C,McCahan SM,Wang W,Butchbach MER

更新日期：2016-10-14 00:00:00

abstract：:The ability of DNA damage to stabilize p53 in all cell cycle stages has not been examined in actively growing cells. The chemotherapeutic drug camptothecin is a topoisomerase I poison. Zeocin is a member of the bleomycin/phleomycin family of antibiotics, known to bind DNA. Both increase the level of p53 albeit by diff...

journal_title：Biochemical and biophysical research communications

authors： Houser S,Koshlatyi S,Lu T,Gopen T,Bargonetti J

更新日期：2001-12-21 00:00:00

abstract：:In Alzheimer's disease (AD), tau protein is abnormally hyperphosphorylated and aggregated into paired helical filaments (PHFs). It was discovered recently that tau is also O-GlcNAcylated in human brains. And O-GlcNAcylation may regulate phosphorylation of tau in a site-specific manner. In this work, we focused on the ...

journal_title：Biochemical and biophysical research communications

authors： Yu CH,Si T,Wu WH,Hu J,Du JT,Zhao YF,Li YM

更新日期：2008-10-10 00:00:00

abstract：:To investigate the involvement of nitric oxide (NO) in the pathogenesis of the cardiovascular system with aging, we studied the basal release of NO in cultured endothelial cells isolated from normal human umbilical veins (HUVECs) at different population doubling levels (PDLs). The release of NO was assayed by a newly ...

journal_title：Biochemical and biophysical research communications

authors： Sato I,Morita I,Kaji K,Ikeda M,Nagao M,Murota S

更新日期：1993-09-15 00:00:00

abstract：:Type I diabetes is a complex disease in which multiple susceptibility loci have been implicated by whole genome scans. IDDM8, a susceptibility locus, is located on chromosome 6q27, however the specific susceptibility gene has yet to be identified. We have examined five potential candidate genes using 36 genetic marker...

journal_title：Biochemical and biophysical research communications

authors： Owerbach D,Piña L,Gabbay KH

更新日期：2004-10-22 00:00:00

abstract：:Receptor tyrosine kinases, mediators of a variety of critical cellular functions, contribute to tumor progression and metastasis. The epidermal growth factor receptor (EGFR), a member of the receptor tyrosine kinase family, is ubiquitously expressed on the surface of mammalian cells. Erlotinib hydrochloride (Tarceva) ...

journal_title：Biochemical and biophysical research communications

authors： Lin P,An F,Xu X,Zhao L,Liu L,Liu N,Wang P,Liu J,Wang L,Li M

更新日期：2015-05-01 00:00:00

abstract：:Accumulating evidence demonstrates that aldosterone can cause extra-cellular matrix (ECM) accumulation, in addition to regulating sodium and potassium homeostasis. Increased extra-cellular matrix production by renal glomerular mesangial cells has been suggested to be involved in pathogenesis of glomerular sclerosis. T...

journal_title：Biochemical and biophysical research communications

authors： Lai L,Chen J,Hao CM,Lin S,Gu Y

更新日期：2006-09-15 00:00:00

abstract：:Integral membrane lysophospholipid acyltransferases (AT) are involved in many reactions that produce phospholipids and triglycerides. Enzymes that utilize lysophosphatidic acid (LPA) as an acceptor substrate have been termed LPAATs, and several are members of the 1-acylglycerol-3-phosphate O-acyltransferase (AGPAT) ge...

journal_title：Biochemical and biophysical research communications

authors： Schmidt JA,Yvone GM,Brown WJ

更新日期：2010-07-09 00:00:00

abstract：:Methotrexate (MTX) is a dihydrofolate reductase (DHFR) inhibitor widely used for treating human cancers, and overexpression of histone deacetylase (HDAC) is usually found in tumors. HDAC inhibitors (HDACi) can reactivate tumor suppressor genes and serve as potential anti-cancer drugs. In this study, we found that MTX ...

journal_title：Biochemical and biophysical research communications

authors： Yang PM,Lin JH,Huang WY,Lin YC,Yeh SH,Chen CC

更新日期：2010-01-15 00:00:00

abstract：:GATA-2 is a transcription factor expressed in stem and progenitor cells of various cell lineages. In this study, we examined the role of GATA-2 in the differentiation of adipocytes, which are the main components of the microenvironment for hematopoiesis. Suppression of GATA-2 in TBR343, a preadipocytic stromal cell li...

journal_title：Biochemical and biophysical research communications

authors： Okitsu Y,Takahashi S,Minegishi N,Kameoka J,Kaku M,Yamamoto M,Sasaki T,Harigae H

更新日期：2007-12-14 00:00:00

abstract：:The fragile X syndrome, one of the most common forms of inherited mental retardation, is caused by an expansion of a polymorphic CGG repeat upstream the coding region of the FMR1 gene. These expansions are associated with hypermethylation of the FMR1 gene, which results in the absence of the gene product, the FMR1 pro...

journal_title：Biochemical and biophysical research communications

authors： Willemsen R,Bontekoe C,Tamanini F,Galjaard H,Hoogeveen A,Oostra B

更新日期：1996-08-05 00:00:00

abstract：:To investigate the effect of ionophores on Cl- distribution in human erythrocyte suspensions, we measured the membrane potential by using 19F and 31P NMR methods. Incubation of human erythrocytes with 0.005 mM of the neutral ionophores valinomycin and nonactin resulted in membrane potentials of -21.2 and -17.8 mV in t...

journal_title：Biochemical and biophysical research communications

authors： Wittenkeller L,Mota de Freitas D,Ramasamy R

更新日期：1992-04-30 00:00:00

abstract：:We previously reported that GLP-1(7-36)amide had glucagonostatic action as well as insulinotropic action in the perfused rat pancreas. In this study, we examined the effect of GLP-1(7-36)amide on glucagon secretion and cAMP concentration in glucagon-secreting cell line, In-R1-G9. GLP-1(7-36)amide (1nM) significantly s...

journal_title：Biochemical and biophysical research communications

authors： Matsumura T,Itoh H,Watanabe N,Oda Y,Tanaka M,Namba M,Kono N,Matsuyama T,Komatsu R,Matsuzawa Y

更新日期：1992-07-15 00:00:00

abstract：:Neocarzinostatin is a radiomimetic antibiotic with a potent cytotoxic effect which elicits a hypersensitive response in human cells homozygous or heterozygous for the gene for ataxia-telangiectasia. The extent and the time course of potentially lethal damage repair and sublethal damage repair following neocarzinostati...

journal_title：Biochemical and biophysical research communications

authors： Shiloh Y,Tabor E,Becker Y

更新日期：1983-01-27 00:00:00