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Association of a CAG/CAA repeat sequence in the TBP gene with type I diabetes.

Abstract：

:Type I diabetes is a complex disease in which multiple susceptibility loci have been implicated by whole genome scans. IDDM8, a susceptibility locus, is located on chromosome 6q27, however the specific susceptibility gene has yet to be identified. We have examined five potential candidate genes using 36 genetic markers, spanning 360kb located near the chromosome 6q27 terminus in 478 families for diabetes association. No associations with type I diabetes susceptibility were detected with the strength previously observed for IDDM1 or IDDM2. However, a novel CAG/CAA polymorphism was detected in exon 3 of the TATA box-binding protein gene, which shows preliminary evidence of association with diabetes susceptibility (p<0.05).

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Owerbach D,Piña L,Gabbay KH

doi

10.1016/j.bbrc.2004.08.159

subject

Has Abstract

pub_date

2004-10-22 00:00:00

pages

865-9

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(04)01946-1

journal_volume

323

pub_type

杂志文章

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