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Sequence analysis of mouse tyrosinase cDNA and the effect of melanotropin on its gene expression.

Abstract：

:Using human tyrosinase cDNA as a probe, a mouse tyrosinase cDNA clone representing approximately 75% of the tyrosinase coding region and a mouse genomic clone which includes the tyrosinase 5' coding sequences were isolated: nucleotide and deduced amino acid sequence of the mouse tyrosinase gene were determined from these clones. The predicted amino acid sequence revealed that the mouse tyrosinase is composed of 533 amino acids with a molecular weight of 60,536. The deduced protein contains 6 potential N-glycosylation sites, two cysteine- and two histidine-rich regions which may serve as copper-binding sites, a potential signal and transmembrane sequences. The mouse and human tyrosinase nucleotide and deduced amino acid sequences are approximately 81% homologous. The level of mouse tyrosinase mRNA was elevated after stimulation of Cloudman S-91 melanoma cells with melanotropin and isobutylmethylxanthine and the level of transcript reflected that of tyrosinase activity and melanin content in the cells.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Kwon BS,Wakulchik M,Haq AK,Halaban R,Kestler D

doi

10.1016/s0006-291x(88)81370-6

subject

Has Abstract

pub_date

1988-06-30 00:00:00

pages

1301-9

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(88)81370-6

journal_volume

153

pub_type

杂志文章

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