CRY2 is suppressed by FOXM1 mediated promoter hypermethylation in breast cancer.

abstract：:Genomic DNA of the phytopathogenic Erwinia chrysanthemi PY35 was partially digested with Sau3AI, ligated into the BamHI site of pBluescript II SK+, and introduced into E. coli. One clone that was able to hydrolyse carboxymethylcellulose and polygalacturonic acid was selected. A 2.9 kb fragment containing the pelL1 gen...

journal_title：Biochemical and biophysical research communications

authors： Park SR,Kim MK,Kim JO,Bae DW,Cho SJ,Cho YU,Yun HD

更新日期：2000-02-16 00:00:00

abstract：:The ATP-sensitive potassium channel of insulin-secreting pancreatic beta-cells is a complex of Kir6.2, a member of the inwardly rectifying potassium channel superfamily, and the sulfonylurea receptor. We have isolated cDNA clones encoding rat Kir6.2. Co-expression of rat Kir6.2 and sulfonylurea receptor in human embry...

journal_title：Biochemical and biophysical research communications

authors： Tokuyama Y,Fan Z,Furuta H,Makielski JC,Polonsky KS,Bell GI,Yano H

更新日期：1996-03-27 00:00:00

abstract：:High homocysteine (Hcy) levels are a well-known independent risk factor for endothelial damage in atherosclerosis. We examined whether a rat intestinal model of ischemia-reperfusion was associated with high Hcy and with the modification of plasma albumin into cysteinylated species (CysAlb). The three treatment groups ...

journal_title：Biochemical and biophysical research communications

authors： Bar-Or D,Curtis CG,Sullivan A,Rael LT,Thomas GW,Craun M,Bar-Or R,Maclean KN,Kraus JP

更新日期：2004-12-24 00:00:00

abstract：:In this investigation, the activities of five enzymes (catalase, superoxide dismutase, glutathione peroxidase, glutathione reductase, glucose-6-dehydrogenase) involved in oxygen radical (OR)-detoxification and antioxidative defense were measured in conjunction with an index of lipid peroxidation in major prostatic lob...

journal_title：Biochemical and biophysical research communications

authors： Ghatak S,Ho SM

更新日期：1996-05-15 00:00:00

abstract：:Triglyceride deposit cardiomyovasculopathy (TGCV) is a rare and newly identified disease among patients requiring cardiac transplantation. TGCV is characterized by cardiomyocyte steatosis and triglyceride (TG)-deposit atherosclerosis, resulting from the abnormal intracellular metabolism of TG. TGCV is classified into ...

journal_title：Biochemical and biophysical research communications

authors： Takagi A,Ikeda Y,Kobayashi K,Kobayashi K,Ikeda Y,Kozawa J,Miyauchi H,Li M,Hashimoto C,Hara Y,Yamaguchi S,Suzuki A,Toda T,Nagasaka H,Hirano KI

更新日期：2018-01-01 00:00:00

abstract：:In cultures of human foreskin fibroblasts most of the cell surface binding sites for 2-chain urokinase are masked and can be exposed by 10 min. incubation on ice at pH 2.5 (A. Bajpai and J.B. Baker (1985), Biochem. Biophys. Res. Commun.133, 475-482). Here we show that incubation on ice at pH 2.5 also releases from the...

journal_title：Biochemical and biophysical research communications

authors： Bajpai A,Baker JB

更新日期：1985-12-31 00:00:00

abstract：:Myxothiazol is a respiratory chain complex III (CIII) inhibitor that binds to the ubiquinol oxidation site Qo of CIII. It blocks electron transfer from ubiquinol to cytochrome b and thus inhibits CIII activity. It has been utilized as a tool in studies of respiratory chain function in in vitro and cell culture models....

journal_title：Biochemical and biophysical research communications

authors： Davoudi M,Kallijärvi J,Marjavaara S,Kotarsky H,Hansson E,Levéen P,Fellman V

更新日期：2014-04-18 00:00:00

abstract：:The aorta-gonad-mesonephros (AGM) region is involved in the generation and maintenance of the first definitive hematopoietic stem cells (HSCs). A mouse AGM-derived cell line, AGM-S3, was shown to support the development of HSCs. To elucidate the molecular mechanisms regulating early hematopoiesis, we obtained subclone...

journal_title：Biochemical and biophysical research communications

authors： Nagao K,Ohta T,Hinohara A,Tahara T,Hagiwara T,Maeda Y,Yoneya T,Sohma Y,Heike T,Nakahata T,Inagaki Y,Nishikawa M

更新日期：2008-12-05 00:00:00

abstract：:Tyrosine protein kinase activity was measured in membranes from DMBA-induced mammary tumors, with Angiotensin II as substrate. The apparent Km for the peptide was 3.3 mM. This enzymatic activity is inhibited by Ca+2; Mn+2 can replace Mg+2 with an increase in the Km for ATP from 47 /microM to 172 microM. The enzymatic ...

journal_title：Biochemical and biophysical research communications

authors： Levy J,Teuerstein I,Marbach M,Radian S,Sharoni Y

更新日期：1984-09-28 00:00:00

abstract：:Efficiency of the induction protocol is crucial for the generation of insulin-producing cells (IPCs) from human dental pulp stem cells (hDPSCs). Here, we established the integrative induction protocol by merging genetic manipulation technique with our previous published 3-step induction protocol aiming to enhance the ...

journal_title：Biochemical and biophysical research communications

authors： Sawangmake C,Rodprasert W,Osathanon T,Pavasant P

更新日期：2020-09-10 00:00:00

abstract：:Homocysteine is an accepted risk factor when its plasma level exceeds the physiological upper limit of 12 mumol/L. We found in vitro that homocysteine is able to lyse the erythrocytes (RBCs) at higher concentrations than 15 mumol/L only when activated polymorphonuclear leukocytes (PMNL) are present. The hemolytic effe...

journal_title：Biochemical and biophysical research communications

authors： Olinescu R,Kummerow FA,Handler B,Fleischer L

更新日期：1996-09-24 00:00:00

abstract：:Free methionine-R-sulfoxide reductase (fRMsr) is a new type of methionine sulfoxide reductase that catalyzes the reduction of free methionine-R-sulfoxide to methionine. This enzyme cannot reduce oxidized methionine residues in proteins. While three Cys residues, Cys-91, Cys-101 and Cys-125, have been demonstrated to b...

journal_title：Biochemical and biophysical research communications

authors： Kwak GH,Kim MJ,Kim HY

更新日期：2010-05-07 00:00:00

abstract：:To analyze the mechanisms of mRNA export from the nucleus to the cytoplasm, we have isolated eleven mutants, ptr [poly(A)(+) RNA transport] 1 to 11, which accumulate poly(A)(+) RNA in the nucleus at a nonpermissive temperature in Schizosaccharomyces pombe. Of those, the ptr5-1 mutant shows dots- or a ring-like accumul...

journal_title：Biochemical and biophysical research communications

authors： Watanabe N,Ikeda T,Mizuki F,Tani T

更新日期：2012-02-03 00:00:00

abstract：:The murine 3T3-L1 preadipocyte cell line is well characterized for its capacity to undergo differentiation into adipocytes under appropriate hormonal stimulation. p107, a member of the retinoblastoma tumor suppressor gene family has been shown to be dramatically upregulated during the early requisite clonal expansion ...

journal_title：Biochemical and biophysical research communications

authors： May JS,Prince AM,Lyle RE,McGehee RE Jr

更新日期：2001-05-18 00:00:00

abstract：:The present study revealed that low density lipoprotein (LDL) obtained from rabbits fed highly purified eicosapentaenoic acid-ethyl ester (EPA-E) (EPA-LDL) was significantly less susceptible to oxidative modification catalyzed by Cu2+ as compared to LDL from rabbits fed a normal diet (control LDL). In a comparison of ...

journal_title：Biochemical and biophysical research communications

authors： Saito H,Chang KJ,Tamura Y,Yoshida S

更新日期：1991-02-28 00:00:00

abstract：:Phosphatases play an important role in cellular signaling and are often found dysregulated in cancers including glioblastoma (GBM). A comprehensive bioinformatics analysis of phosphatases (n = 403) in multiple datasets revealed their deregulation in GBM. Among the differentially regulated phosphatases (n = 186; 46.1%)...

journal_title：Biochemical and biophysical research communications

authors： Tomar VS,Baral TK,Nagavelu K,Somasundaram K

更新日期：2019-07-12 00:00:00

abstract：:The chemokine receptor CCR-7 is expressed in T, NK, and dendritic cells in a time-ordered and stimulus-dependent manner. Thorough analyses of the pharmacological profiles of the recombinant ligands for CCR-7, MIP-3beta/ELC/CK-beta 11, and SLC/Exodus-2/TCA4/6C-kine, using CCR-7-expressing HEK-293E transfectants determi...

journal_title：Biochemical and biophysical research communications

authors： Sullivan SK,McGrath DA,Grigoriadis D,Bacon KB

更新日期：1999-10-05 00:00:00

abstract：:The Frizzled-type cysteine-rich domain (CRD) is a binding motif for soluble-type glycoprotein WNTs, which play key roles in embryogenesis and carcinogenesis. Here, we have cloned and characterized a novel gene MFRP, encoding a type II transmembrane protein with CRD. In addition to CRD, two tandem-repeats containing th...

journal_title：Biochemical and biophysical research communications

authors： Katoh M

更新日期：2001-03-23 00:00:00

abstract：:Type III polyketide synthases (PKSs) play an important role in biosynthesis of various plant secondary metabolites and plant adaptation to environmental stresses. Aquilaria sinensis (A. sinensis) is the main plant species for production of agarwood, little is known about its PKS family. In this study, AsCHS1 and two n...

journal_title：Biochemical and biophysical research communications

authors： Wang X,Zhang Z,Dong X,Feng Y,Liu X,Gao B,Wang J,Zhang L,Wang J,Shi S,Tu P

更新日期：2017-05-13 00:00:00

abstract：:v-Src activates gene expression mediated by serum response elements (SREs) and TPA response elements (TREs). v-Src-induced SRE- and TRE-mediated gene expressions are both dependent upon HaRas. Protein phosphatase 2A (PP2A) is a serine/threonine phosphatase that has been implicated in v-Src-initiated signals. We report...

journal_title：Biochemical and biophysical research communications

authors： Gupta R,Foster DA

更新日期：1994-12-15 00:00:00

abstract：:In rat mesenteric vessels changes in external pH (pHo) alter tension. Changes in intracellular pH (pHi) and calcium ([Ca2+]i) have both been suggested to underlie the tension changes. As no simultaneous measurements of pHi and [Ca2+]i had been made, however, the relative importance and temporal relationship between pH...

journal_title：Biochemical and biophysical research communications

authors： Austin C,Dilly K,Eisner D,Wray S

更新日期：1996-05-15 00:00:00

abstract：:Hepatitis C virus (HCV), a hepacivirus member of the Flaviviridae family, has a positive-stranded RNA genome, which consists of a single open reading frame (ORF) and nontranslated regions (NTRs) at the 5' and 3' ends. The 5'NTR was found to contain an internal ribosomal entry site (IRES), which is required for the tra...

journal_title：Biochemical and biophysical research communications

authors： Kim YK,Kim CS,Lee SH,Jang SK

更新日期：2002-01-11 00:00:00

abstract：:RNA interference (RNAi) mediated inhibition of virus-specific genes has emerged as a potential therapeutic strategy against virus induced diseases. Human hepatitis B virus (HBV) surface antigen (HBsAg) has proven to be a significant risk factor in HBV induced liver diseases, and an increasing number of mutations in HB...

journal_title：Biochemical and biophysical research communications

authors： Cheng TL,Chang WW,Su IJ,Lai MD,Huang W,Lei HY,Chang WT

更新日期：2005-10-28 00:00:00

abstract：:Although "secretory" type II 14-kDa phospholipase A2 (sPLA2) activity has been described in neutrophils, direct evidence of enzyme secretion has been elusive. We have used immunogold electron microscopy with polyclonal and monoclonal antibodies to sPLA2 to demonstrate localization of the enzyme to granules of resting ...

journal_title：Biochemical and biophysical research communications

authors： Rosenthal MD,Gordon MN,Buescher ES,Slusser JH,Harris LK,Franson RC

更新日期：1995-03-17 00:00:00

abstract：:A bovine brain calmodulin-dependent protein kinase undergoes autophosphorylation with a maximal incorporation of 10 mol phosphate per mol enzyme. The autophosphorylated enzyme is fully active, independent of Ca2+ and calmodulin. Although the autophosphorylation reaction depends on Ca2+ and calmodulin, it can be render...

journal_title：Biochemical and biophysical research communications

authors： Zhang GY,Wang JH,Sharma RK

更新日期：1993-03-15 00:00:00

abstract：:Bovine thyroid 100,000 X g supernatant contained calcium-activated, calmodulin-dependent protein kinase (PK-CaM) activity. The PK-CaM was partially purified using ion-exchange chromatography and characterized. PK-CaM, using casein as exogenous substrate, was not stimulated by Ca2+(0-500 microM) or calmodulin (1-10 mic...

journal_title：Biochemical and biophysical research communications

authors： Friedman Y,Henricks L,Poleck T,Levasseur S,Burke G

更新日期：1986-10-15 00:00:00

abstract：:8-Hydroxyguanine (8-OH-Gua) residues were formed in DNA of Ehrlich ascites cells exposed to the carcinogen 4-nitroquinoline 1-oxide. Formation of 8-OH-Gua was confirmed by chemical treatment of calf thymus DNA with the proximate metabolite of this carcinogen, 4-hydroxyaminoquinoline 1-oxide, together with seryl-adenos...

journal_title：Biochemical and biophysical research communications

authors： Kohda K,Tada M,Kasai H,Nishimura S,Kawazoe Y

更新日期：1986-09-14 00:00:00

abstract：:Drosophila Dicer-2 processes RNA substrates into short interfering RNAs (siRNAs). Loquacious-PD (Loqs-PD), a dsRNA-binding protein that associates with Dicer-2, is required for processing of a subset of RNA substrates including hairpin RNAs into siRNAs. Inorganic phosphate-a small molecule present in all cell types-in...

journal_title：Biochemical and biophysical research communications

authors： Fukunaga R

更新日期：2018-04-15 00:00:00

abstract：:Secretion of growth hormone (GH) exhibits marked sexual dimorphism in the rat. To examine the underlying mechanism that involves hypothalamic GH-releasing factor (GRF), we determined pituitary GRF receptor mRNA levels in male and female rats and compared their in vitro abilities to release GRF, an endogenous ligand fo...

journal_title：Biochemical and biophysical research communications

authors： Ono M,Miki N,Murata Y,Osaki E,Tamitsu K,Ri T,Yamada M,Demura H

更新日期：1995-11-22 00:00:00

abstract：:Translationally controlled tumor protein (TCTP) is often designated as a stress-related protein because of its highly regulated expression in stress conditions. Following a thermal shock, TCTP expression is highly upregulated in a variety of cells. However, at present it is not known whether this upregulation has any ...

journal_title：Biochemical and biophysical research communications

authors： Gnanasekar M,Dakshinamoorthy G,Ramaswamy K

更新日期：2009-08-21 00:00:00