Chinchilla "big" and "little" gastrins.

abstract：:Helical hairpins, two closely spaced helical membrane spanning segments separated by a short surface turn, are thought to be common in integral membrane proteins. Here, we study the membrane integration of a naturally occurring helical hairpin from the secretory Na(+)-K(+)-2Cl(-) cotransporter NKCC1. This sequence is ...

journal_title：Biochemical and biophysical research communications

authors： Nagy A,Turner RJ

更新日期：2007-05-04 00:00:00

abstract：:We have recently shown that inhibition of nitric oxide (NO) synthesis by asymmetrical dimethylarginine (ADMA) accelerated endothelial cell (EC) senescence which was prevented by coincubation with L-arginine; however the effect of long-term treatment of l-arginine alone on senescence of ECs have not been investigated. ...

journal_title：Biochemical and biophysical research communications

authors： Scalera F,Closs EI,Flick E,Martens-Lobenhoffer J,Boissel JP,Lendeckel U,Heimburg A,Bode-Böger SM

更新日期：2009-09-04 00:00:00

abstract：:The conformations of the neuropeptide galanin in water and trifluoroethanol solutions have been examined by 1H NMR spectroscopy. Analysis of two-dimensional NMR experiments enabled the assignment of virtually all the 1H resonances of galanin in trifluoroethanol solution and many of the 1H resonances in aqueous solutio...

journal_title：Biochemical and biophysical research communications

authors： Wennerberg AB,Cooke RM,Carlquist M,Rigler R,Campbell ID

更新日期：1990-02-14 00:00:00

abstract：:FIP-3 (NEMO/IKKgamma) is an essential modulator of the activity of NF-kappaB by mechanisms that include alterations in the phosphorylation, ubiquination, and degradation of IkappaBalpha. The multiple protein-protein interactions of FIP-3 (NEMO/IKKgamma) in a high molecular weight IKK complex indicated that this protei...

journal_title：Biochemical and biophysical research communications

authors： Tarassishin L,Horwitz MS

更新日期：2001-07-13 00:00:00

abstract：:Gonadotropin releasing hormone is a hypothalamic decapeptide that stimulates the release of gonadotropic hormones from the anterior pituitary gland. Therapeutically, the human pituitary GnRH receptor is the target of agonists used in the suppression of prostate cancer. Here we report the isolation of a cDNA representi...

journal_title：Biochemical and biophysical research communications

authors： Kakar SS,Musgrove LC,Devor DC,Sellers JC,Neill JD

更新日期：1992-11-30 00:00:00

abstract：:Tamoxifen, a widely used nonsteroidal antiestrogen in the treatment of breast cancer, forms several metabolites. 4-Hydroxytamoxifen (4-OHTam), a metabolite found in the bloodstream, has much higher affinity for the estrogen receptor than tamoxifen itself. Oxidative activation of 4-OHTam induces DNA damage. DNA isolate...

journal_title：Biochemical and biophysical research communications

authors： Sharma M

更新日期：2000-06-24 00:00:00

abstract：:Cell division cycle protein 45 (Cdc45) is crucial for the initiation as well as the elongation process of eukaryotic DNA replication. Our findings suggested that the Cdc45 protein is ubiquitylated and degraded by the proteasome pathway in human cells. Firstly, the fate of Cdc45 protein after induction of terminal diff...

journal_title：Biochemical and biophysical research communications

authors： Pollok S,Grosse F

更新日期：2007-11-03 00:00:00

abstract：:A few decades ago, researchers found emerging evidence showing that a number of sequential events lead to the pathological cascade of Alzheimer's disease (AD) which is caused by the accumulation of amyloid beta (Aβ), a physiological peptide, in the brain. Therefore, regulation of Aβ represents a crucial treatment appr...

journal_title：Biochemical and biophysical research communications

authors： Oh JH,Choi S,Shin J,Park JS

更新日期：2016-09-02 00:00:00

abstract：:Mannose is a simple sugar with a complex life. It is a welcome therapy for genetic and acquired human diseases, but it kills honeybees and blinds baby mice. It could cause diabetic complications. Mannose chemistry, metabolism, and metabolomics in cells, tissues and mammals can help explain these multiple systemic effe...

journal_title：Biochemical and biophysical research communications

authors： Sharma V,Ichikawa M,Freeze HH

更新日期：2014-10-17 00:00:00

abstract：:Vascular endothelial growth factor (VEGF), also known as vascular permeability factor, is highly expressed in the myocardium under various stimuli including hypoxia and ischemia. On the other hand, lipopolysaccharide (LPS) causes systemic inflammatory response syndrome (SIRS), which consists of systemic pathophysiolog...

journal_title：Biochemical and biophysical research communications

authors： Sugishita Y,Shimizu T,Yao A,Kinugawa Ki,Nojiri T,Harada K,Matsui H,Nagai R,Takahashi T

更新日期：2000-02-16 00:00:00

abstract：:The cellular molecular motor kinesin-1 mediates the microtubule-dependent transport of a range of cargo. We have previously identified an interaction between the cargo-binding domain of kinesin-1 heavy chain KIF5B and the membrane-associated SNARE proteins SNAP-25 and SNAP-23. In this study we further defined the mini...

journal_title：Biochemical and biophysical research communications

authors： Morton AM,Cunningham AL,Diefenbach RJ

更新日期：2010-01-01 00:00:00

abstract：:Liposomes prepared from lecithin:cholesterol:p-aminophenyl-alpha-mannoside (7:2:1, v/v/v) were efficiently incorporated into the mouse brain across the blood brain barrier. Furthermore, liposomes injected intraperitoneally were exclusively distributed into lysosome rich fraction and also taken up by glial cells. These...

journal_title：Biochemical and biophysical research communications

authors： Umezawa F,Eto Y

更新日期：1988-06-30 00:00:00

abstract：:The pattern of micrococcal nuclease digestion of chromatin from different organs of Allium cepa has been studied. The DNA from small oligonucleosomes appears to be highly degraded and heterogeneous. In solutions of intermediate ionic strength (0.15 M NaCl) histones H2A and H2B form dimers, however at high salt concent...

journal_title：Biochemical and biophysical research communications

authors： Moreno ML,Puigdomenech P,Palau J

更新日期：1985-06-28 00:00:00

abstract：:We describe here two human VIP receptor cDNA clones isolated from a jejunal epithelial cell cDNA library. The hIVR8 cDNA encodes a human VIP receptor consisting of 460 amino acids and has seven putative transmembrane domains like other G protein-coupled receptors. When expressed in COS-7 cells, hIVR8 conferred specifi...

journal_title：Biochemical and biophysical research communications

authors： Couvineau A,Rouyer-Fessard C,Darmoul D,Maoret JJ,Carrero I,Ogier-Denis E,Laburthe M

更新日期：1994-04-29 00:00:00

abstract：:Lipocortin I-S100 (calcyclin) heterotetramer exhibited ATPase activity in the presence of dsDNA but not ssDNA. To demonstrate its helicase activity, an 80-mer polynucleotide complementary to the replication origin of M13mp18 was synthesized, and the oligonucleotide, (dC)(20), was ligated to either its 5'- or 3'- end f...

journal_title：Biochemical and biophysical research communications

authors： Hirata A,Hirata F

更新日期：2002-02-22 00:00:00

abstract：:Alzheimer's disease is a growing concern in the context of the increasing lifespan of the populations. The work presented here is part of the fight against this threat. It supports a therapeutic approach to reduce the incidence of Alzheimer's disease, taking advantage of the specific binding of several domains of Netr...

journal_title：Biochemical and biophysical research communications

authors： Borel F,Marzocca F,Delcros JG,Rama N,Mehlen P,Ferrer JL

更新日期：2017-07-01 00:00:00

abstract：:Herpes simplex virus-1 (HSV-1) glycoprotein E (gE) is a multifunctional protein capable of both binding the Fc portion of IgG and mediating cell-to-cell spread of HSV-1. Here we report that the domain on gE involved in IgG binding is distinct from the domain involved in mediating cell-to-cell spread. To do this we hav...

journal_title：Biochemical and biophysical research communications

authors： Weeks BS,Sundaresan P,Nagashunmugam T,Kang E,Friedman HM

更新日期：1997-06-09 00:00:00

abstract：:Protein-binding DNA-regions inside and in the vicinity of the phenobarbital-inducible P450bm-3 gene from Bacillus megaterium were characterized by gel-retardation technique and foot-printing analysis. Regions with induction-dependent protein binding capacity were shown to be situated in -279bp/-215bp, -215bp/+83bp and...

journal_title：Biochemical and biophysical research communications

authors： Gaidamakova EK,Karginov VA,Kovalenko SP

更新日期：1994-02-15 00:00:00

abstract：:Acidic fibroblast growth factors (FGF1s) are heparin binding proteins that regulate a wide array of key cellular processes and are also candidates for promising biomedical applications. FGF1-based therapeutic applications are currently limited due to their inherent thermal instability and susceptibility to proteases. ...

journal_title：Biochemical and biophysical research communications

authors： Kerr R,Agrawal S,Maity S,Koppolu B,Jayanthi S,Suresh Kumar G,Gundampati RK,McNabb DS,Zaharoff DA,Kumar TKS

更新日期：2019-10-15 00:00:00

abstract：:The tissue targeting and rate of clearance of cobra venom factor (CVF) from the circulation was studied in mice by intravenous or intraperitoneal injection of radioiodinated CVF. In both modes of administrations, CVF was targeted mainly to liver. CVF injected directly into the blood was cleared from the circulation wi...

journal_title：Biochemical and biophysical research communications

authors： Fu Q,Satyaswaroop PG,Gowda DC

更新日期：1997-02-13 00:00:00

abstract：:Allylisothiocyanate (ANCS) is shown to inhibit (H+ + K+)-ATPase isolated from the parietal cell of hog gastric mucosa. The ATPase is the proton pump in the secretory membrane of the parietal cell and is an essential component of the acid secretory mechanism. Furthermore, ANCS suppresses acid secretion by bullfrog gast...

journal_title：Biochemical and biophysical research communications

authors： Takeguchi N,Nishimura Y,Watanabe T,Mori Y,Morii M

更新日期：1983-04-29 00:00:00

abstract：:Endothelial cells line the inside of all blood vessels forming a structurally and functionally highly heterogenous population of cells. Here we describe the application of the differential RNA display technique to the analysis of the heterogeneity of endothelial cells. Multiple fragment cDNAs from quiescent resting an...

journal_title：Biochemical and biophysical research communications

authors： Kozian DH,Augustin HG

更新日期：1995-04-26 00:00:00

abstract：:The protein folding problem has long been a formidable challenge. Here we present a synthetic natural motif approach that exploits small preexisting structural models for the dissection of forces important in protein folding. An example for this approach is shown in the modification of a 31-residue leucine zipper pept...

journal_title：Biochemical and biophysical research communications

authors： Butcher DJ,Luo Z,Huang Z

更新日期：1999-11-19 00:00:00

abstract：:The aggregation of α-synuclein is clearly related to the pathogenesis of Parkinson's disease. Therefore, detailed understanding of the mechanism of fibril formation is highly valuable for the development of clinical treatment and also of the diagnostic tools. Here, we have investigated the interaction of α-synuclein w...

journal_title：Biochemical and biophysical research communications

authors： Bae SY,Kim S,Hwang H,Kim HK,Yoon HC,Kim JH,Lee S,Kim TD

更新日期：2010-10-01 00:00:00

abstract：:Adenosine inhibits ram sperm adenylate cyclase activity which is membrane-bound and comprises only the catalytic subunit. The inhibition parameters of adenylate cyclase by adenosine were not modified when the enzyme was purified 3 to 5,000 fold. Optimal inhibition by adenosine was found to require a high concentration...

journal_title：Biochemical and biophysical research communications

authors： Henry D,Ferino F,Tomova S,Ferry N,Stengel D,Hanoune J

更新日期：1986-06-30 00:00:00

abstract：:Glycogen storage disease type Ia (GSD-Ia) is caused by a deficiency in glucose-6-phosphatase-α (G6Pase-α or G6PC), a key enzyme in endogenous glucose production. This autosomal recessive disorder is characterized by impaired glucose homeostasis and long-term complications of hepatocellular adenoma/carcinoma (HCA/HCC)....

journal_title：Biochemical and biophysical research communications

authors： Cho JH,Kim GY,Mansfield BC,Chou JY

更新日期：2018-04-15 00:00:00

abstract：:The anti-glutathione antibody scFv 20C9, which we previously isolated from a human synthetic phage antibody scFv library [Hirose, M., Hayano, T., Shirai, H., Nakamura, H., and Kikuchi, M. (1998) Protein Eng. 11, 243-248], was expressed in the E. coli pET system and purified by sequential chromatography on Ni and gluta...

journal_title：Biochemical and biophysical research communications

authors： Horibe T,Furuya R,Iwai A,Yosho C,Tujimoto Y,Kikuchi M

更新日期：2001-03-01 00:00:00

abstract：:p47-phox is one of the cytosolic activation factors of NADPH oxidase in neutrophils and known to translocate to plasma membranes and function by protein kinase C-phosphorylation. In cytosol fraction, prepared from calyculin A-treated neutrophils, the activity of cytosolic factor to activate NADPH oxidase was more redu...

journal_title：Biochemical and biophysical research communications

authors： Yamaguchi M,Saeki S,Yamane H,Okamura N,Ishibashi S

更新日期：1995-11-02 00:00:00

abstract：:S-Adenosyl-l-methionine (SAM) is the biological methyl-group donor for the enzymatic methylation of numerous substrates including proteins. SAM has been reported to activate smooth muscle derived ryanodine receptor calcium release channels. Therefore, we examined the effects of SAM on the cardiac isoform of the ryanod...

journal_title：Biochemical and biophysical research communications

authors： Kampfer AJ,Balog EM

更新日期：2008-07-11 00:00:00

abstract：:We isolated and sequenced a cDNA clone corresponding to the entire coding sequence of rat liver lysosomal cathepsin D. The deduced amino acid sequence revealed that cathepsin D consists of 407 amino acid residues (Mr 44,608) and the 20 NH2-terminal residues seem to constitute a cleavable signal peptide after which 44 ...

journal_title：Biochemical and biophysical research communications

authors： Fujita H,Tanaka Y,Noguchi Y,Kono A,Himeno M,Kato K

更新日期：1991-08-30 00:00:00