Macrophage-mediated N-nitrosation of thioproline and proline.

Abstract:

:Thioproline (Thiazolidine-4-carboxylic acid) and proline were nitrosated by stimulated mouse macrophages in vitro. A macrophage cell line (J774.1, 1.0 x 10(6)/well, 1 ml) was incubated with Escherichia coli lipopolysaccharide, interferon-gamma and thioproline (5 mM) or proline (5 mM). After 72 hr incubation at 37 degrees C, 4 microM N-nitrosothioproline was produced. The amount of N-nitrosoproline was much lower than that of N-nitrosothioproline. Thioproline and proline inhibited the formation of carcinogenic N-nitrosomorpholine. N-nitrosothioproline and N-nitrosoproline are found as major N-nitroso compounds in human urine. Macrophage mediated N-nitrosation may contribute to the formation of these N-nitrosamino acids in the human body.

authors

Miwa M,Tsuda M,Kurashima Y,Hara H,Tanaka Y,Shinohara K

doi

10.1016/0006-291x(89)90001-6

subject

Has Abstract

pub_date

1989-03-15 00:00:00

pages

373-8

issue

2

eissn

0006-291X

issn

1090-2104

pii

0006-291X(89)90001-6

journal_volume

159

pub_type

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