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Molecular cloning and expression of rat contraception associated protein 1 (CAP1), a protein putatively involved in fertilization.

Abstract：

:Epididymal fluid from rats rendered infertile by oral administration of ornidazole contains a protein CAP1 (contraception-associated protein 1) that is absent from epididymal fluid, but present on epididymal sperm, from fertile vehicle-treated rats. The gene for CAP1 has been isolated from a rat testis cDNA library and its expression investigated in different tissues. The deduced protein sequence of CAP1 contains 189 amino-acid residues and database searches revealed a high degree of homology (83-95%) with human and mouse DJ-1 at the nucleotide and amino acid levels. Northern blot hybridisation from different rat tissues indicated that CAP1 is encoded by a 1.6-kilobase RNA transcript and seems to be ubiquitiously expressed in the rat with a high level of expression in the testis.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Wagenfeld A,Gromoll J,Cooper TG

doi

10.1006/bbrc.1998.9512

subject

Has Abstract

pub_date

1998-10-20 00:00:00

pages

545-9

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(98)99512-2

journal_volume

251

pub_type

杂志文章

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