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Regulation of c-myc through intranuclear localization of its RNA subspecies.

Abstract：

:We used fluorescence in situ hybridization (FISH) to detect c-myc RNA subspecies in human COLO 320DM tumor cells. Although the FISH procedure removed the majority of RNAs from the nucleolus, c-myc RNA continued to be detected in both the nucleoplasm and nucleolus. This finding suggests stable association between c-myc RNA and the nucleolus. Nucleolar accumulation of c-myc RNA appeared to be temporally regulated by cell-cycle progression. Hybridization with exon- and strand-specific RNA probes indicated that the non-protein coding exon 1 plays a novel role in determining the subnuclear localization of c-myc RNA. Antisense RNA targeting exon 2 localized only with nucleoplasmic foci, where it might interact with the sense strand. Thus, c-myc gene expression may be regulated by intranuclear localization of its RNA.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Shimizu N,Kawamoto JK,Utani K

doi

10.1016/j.bbrc.2007.05.201

subject

Has Abstract

pub_date

2007-08-03 00:00:00

pages

806-10

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(07)01185-0

journal_volume

359

pub_type

杂志文章

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