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Heteronuclear 113Cd-1H NMR study of metal coordination in the human retinoic acid receptor-beta DNA binding domain.

Abstract：

:The two zinc fingers of the DNA binding domain of the human retinoic acid receptor-beta were labelled with 113Cd. Two- and three-dimensional heteronuclear nuclear magnetic resonance (NMR) experiments show that the first eight conserved cysteine residues coordinate the two zinc ions tetrahedrally. The ninth conserved cysteine is not involved in metal coordination. In each finger one cysteine exhibits a heteronuclear 113Cd-1H coupling constant substantially smaller than those of the other metal binding cysteines.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Knegtel RM,Boelens R,Ganadu ML,George AV,van der Saag PT,Kaptein R

doi

10.1006/bbrc.1993.1442

subject

Has Abstract

pub_date

1993-04-30 00:00:00

pages

492-8

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006291X83714427

journal_volume

192

pub_type

杂志文章

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