Peptide-specific antibodies indicate species heterogeneity of a 42 kDa high-affinity inositol 1,3,4,5-tetrakisphosphate receptor protein from brain.

abstract：:Receptor tyrosine kinases, mediators of a variety of critical cellular functions, contribute to tumor progression and metastasis. The epidermal growth factor receptor (EGFR), a member of the receptor tyrosine kinase family, is ubiquitously expressed on the surface of mammalian cells. Erlotinib hydrochloride (Tarceva) ...

journal_title：Biochemical and biophysical research communications

authors： Lin P,An F,Xu X,Zhao L,Liu L,Liu N,Wang P,Liu J,Wang L,Li M

更新日期：2015-05-01 00:00:00

abstract：:Glycosaminoglycans were prepared as salts of different divalent cations and tested as donors in bovine testicular hyaluronidase catalyzed transglycosylation reactions. All of the metal cations examined had similar binding efficiency of divalent cations to hyaluronan. However, cations bound with different efficiencies ...

journal_title：Biochemical and biophysical research communications

authors： Kakizaki I,Nukatsuka I,Takagaki K,Majima M,Iwafune M,Suto S,Endo M

更新日期：2011-03-11 00:00:00

abstract：:The biological function of hnRNP family proteins is widely diverse and involved in pre-mRNA processing, transcriptional regulation, recombination, and telomere maintenance. In the course of our study on the elucidation of biological functions of minisatellite DNA, we isolated several nuclear proteins that bind to the ...

journal_title：Biochemical and biophysical research communications

authors： Tanaka E,Fukuda H,Nakashima K,Tsuchiya N,Seimiya H,Nakagama H

更新日期：2007-06-29 00:00:00

abstract：:The loss of paramagnetism of the stable free radical 4,4'-di-tert.-butyl- diphenyl-1-nitroxy during illumination of the photosensitizer meso-tetrahydroxyphenyl chlorine by light above 620 nm in the absence of oxygen has been followed by kinetic ESR spectroscopy. Addition of the spin trap alpha-(4-pyridyl-1-oxide)- N-t...

journal_title：Biochemical and biophysical research communications

authors： Kriska T,Korecz L,Nemes I,Gál D

更新日期：1995-10-04 00:00:00

abstract：:Non-Alzheimer's disease of the frontal type, or frontotemporal dementia (FTD), is the second most common form of dementia. Yet, a detailed characterization of the disease has been especially limiting. To identify mechanisms possibly involved in disease pathology or progression, a proteomic analysis of proteins isolate...

journal_title：Biochemical and biophysical research communications

authors： Schweitzer K,Decker E,Zhu L,Miller RE,Mirra SS,Spina S,Ghetti B,Wang M,Murrell J

更新日期：2006-09-22 00:00:00

abstract：:Using a specific radioimmunoassay we have isolated and sequenced a new 45-amino acid peptide from rat atria which exhibits similar physiological and pharmacological properties to rat atrial natriuretic peptide (rANP). We have termed the new peptide iso-rANP, because of its functional and structural similarities to rAN...

journal_title：Biochemical and biophysical research communications

authors： Flynn TG,Brar A,Tremblay L,Sarda I,Lyons C,Jennings DB

更新日期：1989-06-15 00:00:00

abstract：:CrkII is an intracellular adaptor protein involved in signal transduction by various growth factors. Activation of PDGF alpha-receptor resulted in its association with CrkII in vivo. In contrast, binding of CrkII to the PDGF beta-receptor was negligible, despite its becoming prominently phosphorylated. Bacterially exp...

journal_title：Biochemical and biophysical research communications

authors： Matsumoto T,Yokote K,Take A,Takemoto M,Asaumi S,Hashimoto Y,Matsuda M,Saito Y,Mori S

更新日期：2000-04-02 00:00:00

abstract：:Dexamethasone (DEX) induces apoptosis in lymphocytes, while protecting some cancer cells from apoptosis, by a poorly understood mechanism. In this study, we examined the potential role of the forkhead transcription factor (FOXO3A) in DEX-induced apoptosis. Unphosphorylated FOXO3A, the active form of FOXO3A, can transl...

journal_title：Biochemical and biophysical research communications

authors： Ma J,Xie Y,Shi Y,Qin W,Zhao B,Jin Y

更新日期：2008-12-19 00:00:00

abstract：:The yellow locus in Drosophila is involved in both cuticle development and behaviour. However, the function of the encoded protein is unknown. Here we have characterised the sequence and expression pattern of a new Drosophila gene, designated yellow-B, encoding a 453-amino-acid protein that is 57% identical to Yellow....

journal_title：Biochemical and biophysical research communications

authors： Maleszka R,Kucharski R

更新日期：2000-04-21 00:00:00

abstract：:We investigated the effects of neuropeptide Y on the prostacyclin production of cultured porcine aortic endothelial cells by measuring the stable metabolite of prostacyclin, 6-keto-prostaglandin F1 alpha, by radioimmunoassay. Neuropeptide Y induced dose- and time-dependent stimulation of prostacyclin production by cul...

journal_title：Biochemical and biophysical research communications

authors： Kawamura K,Smith TL,Zhou Q,Kummerow FA

更新日期：1991-08-30 00:00:00

abstract：:Triacsin C, a product of Streptmyces sp. SK-1894, was previously reported as an inhibitor of long chain acyl-CoA synthetase. Pretreatment with triacsin C (500 nM) for 1h enhanced production of platelet-activating factor in rat neutrophils, followed by stimulation with A23187 or fMLP. Amount of lyso-PAF was also augume...

journal_title：Biochemical and biophysical research communications

authors： Hayashi M,Imai Y,Naraba H,Tomoda H,Omura S,Oh-ishi S

更新日期：1992-11-16 00:00:00

abstract：:Y-box or inverted CCAAT box-binding proteins are multifunctional regulators of transcription and translation of several genes. Although YB-1 has been shown to play a key role in cell cycle, to date, there is no direct evidence. We disrupted one allele of Chk-YB-1b in a chicken pre-B lymphocyte cell line, DT40. Compare...

journal_title：Biochemical and biophysical research communications

authors： Swamynathan SK,Varma BR,Weber KT,Guntaka RV

更新日期：2002-08-16 00:00:00

abstract：:Overexpression of AtNTRC (AtNTRC(OE)) in Arabidopsis thaliana led to a freezing and cold stress tolerance, whereas a knockout mutant (atntrc) showed a stress-sensitive phenotype. Biochemical analyses showed that the recombinant AtNTRC proteins exhibited a cryoprotective activity for malate dehydrogenase and lactic deh...

journal_title：Biochemical and biophysical research communications

authors： Moon JC,Lee S,Shin SY,Chae HB,Jung YJ,Jung HS,Lee KO,Lee JR,Lee SY

更新日期：2015-08-07 00:00:00

abstract：:A great challenge for gene therapy is to develop a high efficient gene delivery system with low toxicity. Nonviral vectors are still attractive although the current agents displayed some disadvantages (i.e., low transfection efficiency, high toxicity). To overcome the high toxicity of poly(ethylene imine) (PEI) and lo...

journal_title：Biochemical and biophysical research communications

authors： Liang B,He ML,Xiao ZP,Li Y,Chan CY,Kung HF,Shuai XT,Peng Y

更新日期：2008-03-21 00:00:00

abstract：:Cathepsin E is a major intracellular aspartic protease which is predominantly present in the cells of immune system and is frequently implicated in antigen processing via the MHC class II pathway. In the present review some of the known features of cathepsin E such as tissue distribution, subcellular localization, enz...

journal_title：Biochemical and biophysical research communications

authors： Zaidi N,Kalbacher H

更新日期：2008-03-14 00:00:00

abstract：:Many plasma membrane proteins, including the epidermal growth factor (EGF) receptor, possess basic regions on the cytoplasmic surface of the membrane. To examine the function of these positively charged regions, we constructed mutated EGF receptor genes lacking this region by substitution of the basic amino acid resid...

journal_title：Biochemical and biophysical research communications

authors： Yamane K,Toyoshima C,Nishimura S

更新日期：1992-05-15 00:00:00

abstract：:The primary structure of human selenium-dependent phospholipid hydroperoxide glutathione peroxidase (GPX4) was determined by genomic cloning. The gene structure of GPX4 spans only 2.8 kb and consists of 7 exons. The coding sequence resides on all 7 exons, and the mitochondrial leader sequence is contained entirely wit...

journal_title：Biochemical and biophysical research communications

authors： Kelner MJ,Montoya MA

更新日期：1998-08-10 00:00:00

abstract：:Leukemia cells respond to toxic stimuli by undergoing a form of programmed cell death known as apoptosis. However, the signaling events responsible for the execution of this form of death are poorly understood. Mitogen-activated protein kinase (MAPK) signaling cascades are involved in the cellular response to extracel...

journal_title：Biochemical and biophysical research communications

authors： Stadheim TA,Kucera GL

更新日期：1998-04-07 00:00:00

abstract：:The fragile X mental retardation 1 (FMR1) protein binds mRNA and acts as a negative regulator of translation. Lack of FMR1 causes the most common neurological disorder, fragile X syndrome, while its overexpression is associated with metastasis of breast cancer. Its activity has been well-studied in nervous tissue, but...

journal_title：Biochemical and biophysical research communications

authors： Choi YN,Jeong DH,Lee JS,Yoo SJ

更新日期：2014-10-10 00:00:00

abstract：:Cysteine proteases and matrix metalloproteinases (MMPs) are important factors in the degradation of organic matrix components of bone. Osteoprotegerin (OPG) is an osteoblast-secreted decoy receptor that inhibits osteoclast differentiation and activation. This study investigated the direct effects of human OPG on cathe...

journal_title：Biochemical and biophysical research communications

authors： Wittrant Y,Couillaud S,Theoleyre S,Dunstan C,Heymann D,Rédini F

更新日期：2002-04-26 00:00:00

abstract：:2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a well-known immunotoxic compound affecting the expression of inflammatory genes. We found that TCDD induces the expression of the B-cell activating factor of the tumor necrosis factor family (BAFF), B-lymphocyte chemoattractant (BLC), CC-chemokine ligand 1 (CCL1), and the...

journal_title：Biochemical and biophysical research communications

authors： Vogel CF,Sciullo E,Matsumura F

更新日期：2007-11-23 00:00:00

abstract：:To examine the effects of a replacement of the proximal or the distal histidine on the structure of hemoglobin (Hb), absorption and circular dichroic (CD) spectra of five species of Hbs M in the visible region were measured. Four Hbs M had a characteristic but a similar absorption spectrum upon amino acid substitution...

journal_title：Biochemical and biophysical research communications

authors： Nagai M,Takama S,Yoneyama Y

更新日期：1985-04-30 00:00:00

abstract：:N(6)-methyl-2(')-deoxyadenosine (MedAdo) is a nucleoside naturally found in prokaryotic DNA. Interestingly, the N(6)-methylation of adenine in DNA seems to have been counter-selected during the course of evolution since MedAdo has not been detected in mammalian DNA until now. We show here that treatment with MedAdo in...

journal_title：Biochemical and biophysical research communications

authors： Charles MP,Ravanat JL,Adamski D,D'Orazi G,Cadet J,Favier A,Berger F,Wion D

更新日期：2004-02-06 00:00:00

abstract：:Carboxysome, encapsulating an enzymatic core within an icosahedral-shaped semipermeable protein shell, could enhance CO2 fixation under low CO2 conditions in the environment. The shell of Halothiobacillus neapolitanus α-carboxysome possesses two 38% sequence-identical pentameric proteins, namely CsoS4A and CsoS4B. How...

journal_title：Biochemical and biophysical research communications

authors： Zhao YY,Jiang YL,Chen Y,Zhou CZ,Li Q

更新日期：2019-07-30 00:00:00

abstract：:Docetaxel efficiency in the therapy of prostate cancer (PCa) patients is limited due to the development of chemoresistance. Recent studies have implied a role of INPP4B in tumor chemoresistance, while the effects of INPP4B on docetaxel resistance in PCa have not been elucidated. In the present study, the docetaxel-res...

journal_title：Biochemical and biophysical research communications

authors： Chen H,Li H,Chen Q

更新日期：2016-08-26 00:00:00

abstract：:Altered brain cholesterol homeostasis plays a key role in neurodegenerative diseases such as Alzheimer's disease (AD). For a long time, the blood-brain barrier (BBB) was basically considered as a barrier isolating the brain from circulating cholesterol, however, several lines of evidence now suggest that the BBB stric...

journal_title：Biochemical and biophysical research communications

authors： Gosselet F,Saint-Pol J,Fenart L

更新日期：2014-04-11 00:00:00

abstract：:Leucine-rich alpha(2)-glycoprotein (LRG) is a plasma protein in which leucine-rich repeats (LRRs) were first discovered. Although the physiological function of LRG is not known, increases in the serum level of LRG have been reported in various diseases. In this study, we found that LRG was induced by recombinant human...

journal_title：Biochemical and biophysical research communications

authors： Shirai R,Hirano F,Ohkura N,Ikeda K,Inoue S

更新日期：2009-05-15 00:00:00

abstract：:The ability of tissue plasminogen activator (tPA) to induce human umbilical vein endothelial (HUVE) cell migration was studied using an in vitro, serum-free wound assay system. At pharmacological doses, tPA stimulated HUVE cell migration dose-dependently. Treatment of cells with epsilon amino caproic acid (EACA) to de...

journal_title：Biochemical and biophysical research communications

authors： Inyang AL,Tobelem G

更新日期：1990-09-28 00:00:00

abstract：:Small heat-shock proteins (sHSPs) represent an abundant and ubiquitous family of molecular chaperones. The current model proposes that sHSPs function to prevent irreversible aggregation of non-native proteins by forming soluble complex. The chaperone activity of sHSPs is usually determined by the capacity to suppress ...

journal_title：Biochemical and biophysical research communications

authors： Jiao W,Li P,Zhang J,Zhang H,Chang Z

更新日期：2005-09-16 00:00:00

abstract：:In the case of a new viral disease outbreak, an immediate development of virus detection kits and vaccines is required. For COVID-19, we established a rapid production procedure for SARS-CoV-2 spike protein (S protein) by using the baculovirus-silkworm expression system. The baculovirus vector-derived S proteins were ...

journal_title：Biochemical and biophysical research communications

authors： Fujita R,Hino M,Ebihara T,Nagasato T,Masuda A,Lee JM,Fujii T,Mon H,Kakino K,Nagai R,Tanaka M,Tonooka Y,Moriyama T,Kusakabe T

更新日期：2020-08-20 00:00:00