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Secretion of insulin-like growth factor II into milk.

Abstract：

:125I-labeled insulin-like growth factor II (IGF-II) was infused directly into the pudic artery supplying one gland of lactating goats (n = 4). Maximum specific activity for [125I]IGF-II transferred into milk from the infused gland was reached 60 min after that in plasma and was 2.5 fold greater than in milk from the non-infused gland. Inclusion of either 67.5 nmoles unlabeled IGF-II or IGF-I had no influence on the amount or pattern of secretion of [125I]IGF-II into milk from either gland. While the temporal pattern of secretion of [125I]IGF-II into milk was consistent with a transcellular mechanism of transfer, the lack of competition by unlabeled IGF-II or IGF-I suggests a non-specific mechanism is operable, which contrasts to secretion of IGF-I.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Prosser CG,Fleet IR

doi

10.1016/s0006-291x(05)80322-5

subject

Has Abstract

pub_date

1992-03-31 00:00:00

pages

1230-7

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(05)80322-5

journal_volume

183

pub_type

杂志文章

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