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Characteristics of pre-S2 region of hepatitis B virus.

Abstract：

:The nucleotide sequence of our cloned HBV DNA (subtype adw) has been determined. When the 165-nucleotide sequence of the pre-S2 region was compared with 7 other published sequences (subtypes adw, adr, ayw, and adyw), we found 38 nucleotide substitutions among different subtypes and 4 (adr) or 6 (adw and ayw) substitutions within the same subtype. Analysis of the predicted amino acid sequence from the known nucleotide sequences indicates that: there are 20 amino acid substitutions, the longest conserved amino acid sequence is located between amino acids 23 to 34, and the 54th amino acid is identical within the same subtype but varies in different subtypes.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Lo SJ,Chen ML,Chien ML,Lee YH

doi

10.1016/0006-291x(86)90006-9

subject

Has Abstract

pub_date

1986-03-13 00:00:00

pages

382-8

issue

2

eissn

0006-291X

issn

1090-2104

pii

0006-291X(86)90006-9

journal_volume

135

pub_type

杂志文章

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