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Increased levels of myosin mRNAs in spontaneously hypertensive rat heart.

Abstract：

:RNAs isolated from normal and spontaneously hypertensive (SHR) rat heart tissues were examined by direct hybridization assay using cloned DNA probes containing chicken cardiac myosin light chain and heavy chain specific cDNA sequences. In 7 weeks old SHR heart, the level of mRNA hybridizable to these probes is the same as in normal rat heart. However, at 18 weeks of age, when hypertrophy in SHR is well established as a consequence of age-related increase in blood pressure and cardiac mass, there is an increase in SHR mRNA levels consistent with the increase in the corresponding proteins. Thus, the increase in mRNAs for major myofibrillar proteins and the onset of hypertrophic state in SHR appear to occur simultaneously.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Delaney P,Vitek S,Cribbs L,Siddiqui MA

doi

10.1016/0006-291x(85)91205-7

subject

Has Abstract

pub_date

1985-10-30 00:00:00

pages

820-8

issue

2

eissn

0006-291X

issn

1090-2104

pii

0006-291X(85)91205-7

journal_volume

132

pub_type

杂志文章

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