MicroRNAs expression in ox-LDL treated HUVECs: MiR-365 modulates apoptosis and Bcl-2 expression.

abstract：:Previously, we have demonstrated evidence suggesting that SUMO4 negatively regulates NFkappaB transcriptional activity, probably through sumoylation of IkappaBalpha. Here, we present data indicating that SUMO4 possesses the capacity to conjugate to IkappaBalpha. Luciferase reporter assays in 3T3 cells deficient for Ik...

journal_title：Biochemical and biophysical research communications

authors： Wang CY,Yang P,Li M,Gong F

更新日期：2009-04-17 00:00:00

abstract：:Receptors for atrial natriuretic peptide (ANP) are heterogeneous: an approximately 140-kDa receptor exhibits ANP-stimulated guanylate cyclase activity whereas an approximately 65-kDa receptor is thought to act only as a clearance-storage protein. We have used photoaffinity labeling techniques to show that the human ce...

journal_title：Biochemical and biophysical research communications

authors： Watt VM,Yip CC

更新日期：1989-10-31 00:00:00

abstract：:We found that pyridoxal phosphate shows considerable inhibition of cathepsins. CLIK-071, in which the phosphate ester of position 3 of pyridoxal phosphate was replaced by propionate, strongly inhibited cathepsin B. Three new types of synthetic pyridoxal propionate derivatives showing specific inhibition of cathepsin K...

journal_title：Biochemical and biophysical research communications

authors： Katunuma N,Matsui A,Inubushi T,Murata E,Kakegawa H,Ohba Y,Turk D,Turk V,Tada Y,Asao T

更新日期：2000-01-27 00:00:00

abstract：:The ability of phospholipase C inhibitors to inhibit Ca2+ channel stimulation and Ca2+ release from intracellular stores evoked by norepinephrine in single rat portal vein myocytes was investigated in the aim of identifying the type of phospholipase C involved in the transduction pathways activated by alpha 1A- and al...

journal_title：Biochemical and biophysical research communications

authors： Macrez-Leprêtre N,Morel JL,Mironneau J

更新日期：1996-01-05 00:00:00

abstract：:Injection of DN-BR mRNA encoding a dominant negative type I receptor for bone morphogenetic protein 4 (BMP4) converted prospective ectoderm into neural tissue in Xenopus animal cap explants, in the absence of expression of mesodermal marker genes. The injected caps expressed a general neural marker NCAM and the forebr...

journal_title：Biochemical and biophysical research communications

authors： Xu RH,Kim J,Taira M,Zhan S,Sredni D,Kung HF

更新日期：1995-07-06 00:00:00

abstract：:Genes for the human vacuolar type H(+)-ATPase proteolipid (16-kDa) subunit were cloned and their nucleotide sequences were determined. Comparison of the deduced sequences indicated that at least four genes including pseudogenes are present in the human genome. One of them corresponded to that for the 16-kDa subunit ex...

journal_title：Biochemical and biophysical research communications

authors： Hasebe M,Hanada H,Moriyama Y,Maeda M,Futai M

更新日期：1992-03-16 00:00:00

abstract：:The whole-cell patch-clamp technique has been applied to elucidate the effects of H2O2 and the SH-group reagent 2,2'-dithio-bis(5-nitropyridine) (DTBNP) on Ca2+ currents of mouse pancreatic B-cells. We also tested the effect of DTBNP on the whole-cell K+ ATP current. DTBNP (20 and 100 mumol/l) blocked both the current...

journal_title：Biochemical and biophysical research communications

authors： Krippeit-Drews P,Britsch S,Lang F,Drews G

更新日期：1994-04-29 00:00:00

abstract：:The crypt-villi axis of intestinal mucosa maintains homeostasis by renewal of epithelia, and also exhibits different properties from undifferentiated to terminally differentiated cells. We investigated differential susceptibility to genotoxin-induced cell death, based on the degree of differentiation of epithelial cel...

journal_title：Biochemical and biophysical research communications

authors： Chae B,Yang KM,Kim TI,Kim WH

更新日期：2009-01-23 00:00:00

abstract：:The optical spectrum of Sperm Whale myoglobin, which has been freshly reconstituted with iron protoporphyrin-IX, is shown to be different from that obtained from the native myoglobin, and from the reconstituted, incubated myoglobin (These last two have equivalent absorption spectra). The effect is immediately evident ...

journal_title：Biochemical and biophysical research communications

authors： Gebe JA,Peyton DH,Peyton JA

更新日期：1989-05-30 00:00:00

abstract：:The MCF-7 human breast cancer cell line is routinely used as a model system for the study of ER+, estrogen-responsive human breast cancer. Although most investigators have found these cells to be estrogen-responsive, there are reports that some stocks of MCF-7 cells may be either insensitive or may display decreased s...

journal_title：Biochemical and biophysical research communications

authors： Klotz DM,Castles CG,Fuqua SA,Spriggs LL,Hill SM

更新日期：1995-05-16 00:00:00

abstract：:The inward rectifier potassium channel, Kir2.1, contributes to the I(K1) current in cardiac myocytes and is closely associated with atrial fibrillation. Strong evidences have shown that atrial dilatation or stretch may result in atrial fibrillation. However, the role of Kir2.1 channels in the stretch-mediated atrial f...

journal_title：Biochemical and biophysical research communications

authors： He Y,Xiao J,Yang Y,Zhou Q,Zhang Z,Pan Q,Liu Y,Chen Y

更新日期：2006-12-15 00:00:00

abstract：:B7-H3, an immunoregulatory protein, has been found highly expressed in several cancer types, and involved in cancer cell migration and invasion. Here, we investigated the role of B7-H3 in oxaliplatin resistance in colorectal cancer (CRC) cells. Transient silencing of B7-H3 enhanced oxaliplatin sensitivity by increasin...

journal_title：Biochemical and biophysical research communications

authors： Zhang P,Chen Z,Ning K,Jin J,Han X

更新日期：2017-08-26 00:00:00

abstract：:Circulating hormones are engaged in initiating and controlling the process of spermatogenesis, however, the Sertoli cell tight junctions prevent these substances from directly influencing the spermatogenic cells. Thus, the Sertoli cells play a vital role in regulating the spermatogenic process. Our studies correlate r...

journal_title：Biochemical and biophysical research communications

authors： Page KC,Heitzman DA,Chernin MI

更新日期：1996-05-15 00:00:00

abstract：:Cardiac hypertrophy is a major predictor of heart failure and of morbidity and mortality in developed countries. Many hormones and growth factors induce cardiac hypertrophy via activation of members of the phospholipase C (PLC) family. The expression pattern of the PLCbeta isozyme subfamily was investigated in neonata...

journal_title：Biochemical and biophysical research communications

authors： Schnabel P,Mies F,Nohr T,Geisler M,Böhm M

更新日期：2000-08-18 00:00:00

abstract：:X-linked Emery-Dreifuss muscular dystrophy is usually caused by absence of the nuclear membrane protein, emerin, due to nonsense mutations or deletions, but a few missense mutations also exist. A pathogenic g993t mutation causes a Q133H change in the nuclear targeting region of emerin, but it may also reduce emerin le...

journal_title：Biochemical and biophysical research communications

authors： Holt I,Clements L,Manilal S,Morris GE

更新日期：2001-10-12 00:00:00

abstract：:The hpa cluster of Escherichia coli W ATCC 11105 encodes the enzymes involved in the catabolism of 4-hydroxyphenylacetate (4-HPA). The catabolic genes are organized in two operons, the hpaBC operon, which produces the hydroxylase activity, and the meta operon, which encodes the enzymes that cleave the aromatic ring an...

journal_title：Biochemical and biophysical research communications

authors： Prieto MA,García JL

更新日期：1997-03-27 00:00:00

abstract：:microRNAs (miRNAs) are frequently dysregulated in human malignancies. It was recently shown that miR-204-5p is downregulated in papillary thyroid carcinoma (PTC); however, the functional significance of this observation is not known. This study investigated the role of miR-204-5p in PTC. Overexpressing miR-204-5p supp...

journal_title：Biochemical and biophysical research communications

authors： Liu L,Wang J,Li X,Ma J,Shi C,Zhu H,Xi Q,Zhang J,Zhao X,Gu M

更新日期：2015-02-20 00:00:00

abstract：:Most vertebrates possess at least two gonadotropin-releasing hormone (GnRH) neuron types. To understand the physiological significance of the multiple GnRH systems in the brain, we examined three GnRH neuron type-specific transcriptomes using single-cell microarray analyses in the medaka (Oryzias latipes). A microarra...

journal_title：Biochemical and biophysical research communications

authors： Moriya S,Ogawa S,Parhar IS

更新日期：2013-06-14 00:00:00

abstract：:K63-linked polyubiquitination of proteins regulates their trafficking into specific cellular pathways such as endocytosis and autophagy. CYLD, a deubiquitinase specific for K63-linked polyubiquitins, is present in high quantities at the postsynaptic density (PSD). It was previously shown that, under excitatory conditi...

journal_title：Biochemical and biophysical research communications

authors： Thein S,Pham A,Bayer KU,Tao-Cheng JH,Dosemeci A

更新日期：2014-07-18 00:00:00

abstract：:The HMGA family proteins HMGA1a and HMGA1b are nuclear nonhistone species implicated in a wide range of cellular processes including inducible gene transcription, modulation of chromosome structure through nucleosome and chromosome remodeling, and neoplastic transformation. HMGA proteins are highly modified, and chang...

journal_title：Biochemical and biophysical research communications

authors： Miranda TB,Webb KJ,Edberg DD,Reeves R,Clarke S

更新日期：2005-10-28 00:00:00

abstract：:We compared the intracellular signalling pathways through Ret tyrosine kinase activated by glial cell line-derived neurotrophic factor (GDNF), multiple endocrine neoplasia (MEN) 2A, or MEN 2B mutation. Tyrosine phosphorylation of Grb2-associated binder-1 (Gab1) and activation of phosphatidylinositol 3-kinase (PI 3-kin...

journal_title：Biochemical and biophysical research communications

authors： Murakami H,Iwashita T,Asai N,Shimono Y,Iwata Y,Kawai K,Takahashi M

更新日期：1999-08-19 00:00:00

abstract：:The cDNA encoding human ferrochelatase [EC 4.99.1.1] was isolated from a human placenta cDNA library in bacteriophage lambda gt11 by screening with a radiolabeled fragment of mouse ferrochelatase cDNA. The cDNA had an open reading frame of 1269 base pairs (bp) encoding a protein of 423 amino acid residues (Mr. 47,833)...

journal_title：Biochemical and biophysical research communications

authors： Nakahashi Y,Taketani S,Okuda M,Inoue K,Tokunaga R

更新日期：1990-12-14 00:00:00

abstract：:Deficiency in the DNA mismatch repair (MMR) is frequently involved in various cancers. The hMSH3 gene is one of the human MMR genes whose role in bladder cancer is not known. We hypothesized that down-regulation of the hMSH3 gene might be involved in bladder cancer. In this study we analyzed this gene with regard to f...

journal_title：Biochemical and biophysical research communications

authors： Kawakami T,Shiina H,Igawa M,Deguchi M,Nakajima K,Ogishima T,Tokizane T,Urakami S,Enokida H,Miura K,Ishii N,Kane CJ,Carroll PR,Dahiya R

更新日期：2004-12-17 00:00:00

abstract：:Signal transduction by transforming growth factor-beta (TGF-beta) involves the formation of a heteromeric complex of two transmembrane serine/threonine kinase receptors, type I (T beta R-I) and type II (T beta R-II). In the region preceeding the kinase domain of T beta R-I there is a glycine- and serine-rich sequence,...

journal_title：Biochemical and biophysical research communications

authors： Franzén P,Heldin CH,Miyazono K

更新日期：1995-02-15 00:00:00

abstract：:The developing and the adult brain respond in similar ways to ischemia, but also display clear differences. For example, the relative contributions of necrosis and apoptosis to neuronal death may be different, such that apoptotic mechanisms would be more prevalent in the developing brain. During normal development, mo...

journal_title：Biochemical and biophysical research communications

authors： Blomgren K,Zhu C,Hallin U,Hagberg H

更新日期：2003-05-09 00:00:00

abstract：:Dexamethasone (Dex) induces direct cytotoxicity to cultured osteoblasts. The benzimidazole derivative compound 991 ("C991") is a novel and highly-efficient AMP-activated protein kinase (AMPK) activator. Here, in both MC3T3-E1 osteoblastic cells and primary murine osteoblasts, treatment with C991 activated AMPK signali...

journal_title：Biochemical and biophysical research communications

authors： Xu YY,Chen FL,Ji F,Fei HD,Xie Y,Wang SG

更新日期：2018-01-01 00:00:00

abstract：:Available evidence suggests that insulin-like growth factor I receptor (IGF-IR) expression leads to increased cellular radioresistance. The most direct explanation of these findings predicts that IGF-IR is the source of survival signals in resistant cells. Mutational analysis revealed that protein truncated at amino a...

journal_title：Biochemical and biophysical research communications

authors： Yu D,Shibuya H,Miura M

更新日期：2003-11-07 00:00:00

abstract：:In the present study, we tested the anti-pancreatic cancer activity by AT406, a small-molecule antagonist of IAP (inhibitor of apoptosis proteins). In established (Panc-1 and Mia-PaCa-2 lines) and primary human pancreatic cancer cells, treatment of AT406 significantly inhibited cell survival and proliferation. Yet, sa...

journal_title：Biochemical and biophysical research communications

authors： Jiang Y,Meng Q,Chen B,Shen H,Yan B,Sun B

更新日期：2016-09-09 00:00:00

abstract：:Lipopolysaccharides (LPS) of Porphyromonas gingivalis have been implicated in the initiation and development of periodontal diseases. In a previous study, we investigated the signal transduction pathway of P. gingivalis and demonstrated that LPS stimulates the production of interleukin (IL)-6 in human gingival fibrobl...

journal_title：Biochemical and biophysical research communications

authors： Wang PL,Shirasu S,Shinohar M,Azuma Y,Daito M,Yasuda H,Ohura K

更新日期：1999-09-24 00:00:00

abstract：:NMR spectroscopy is used to compare the structure of the EGF-like domain of heregulin-alpha and HT1, a mutated form of heregulin-alpha with significantly reduced activity. HT1 is a chimeric protein that has the first seven residues of transforming growth factor-alpha and the sequence of heregulin-alpha from the first ...

journal_title：Biochemical and biophysical research communications

authors： Adler M,Thompson SA

更新日期：1999-03-05 00:00:00