Differential regulation of phospholipase C-beta isozymes in cardiomyocyte hypertrophy.

abstract：:The factors which control the formation of lactiferous ducts during mammary gland development are not yet fully understood. To address this issue, we assessed the effect of the multifunctional cytokine transforming growth factor-beta-1 (TGF-beta1) on the morphogenetic properties of TAC-2.1 mammary epithelial cells gro...

journal_title：Biochemical and biophysical research communications

authors： Soriano JV,Orci L,Montesano R

更新日期：1996-03-27 00:00:00

abstract：:Cisplatin is one of the most widely used anticancer agents. Cisplatin-induced cytotoxicity results from its ability to form cisplatin-DNA adducts within the cellular genome which can inhibit the transcription of genes and the replication of DNA. Cisplatin-adducts are primarily removed by the nucleotide excision repair...

journal_title：Biochemical and biophysical research communications

authors： Yang WL,Cvijic ME,Ishii K,Chin KV

更新日期：1998-09-29 00:00:00

abstract：:To investigate the mechanism underlying the antiatherogenic effect of estrogen, we examined the role of estrogen in the regulation of endothelin-1 (ET-1) production by cultured bovine carotid arterial endothelial cells. Treatment of the cells with 17beta-estradiol dose dependently inhibited gene expression and peptide...

journal_title：Biochemical and biophysical research communications

authors： Akishita M,Kozaki K,Eto M,Yoshizumi M,Ishikawa M,Toba K,Orimo H,Ouchi Y

更新日期：1998-10-09 00:00:00

abstract：:Cereblon (CRBN) was originally identified as a target protein for a mild type of mental retardation in humans. However, recent studies showed that CRBN acts as a negative regulator of AMP-activated protein kinase (AMPK) by binding directly to the AMPK catalytic subunit. Because AMPK is implicated in myocardial ischemi...

journal_title：Biochemical and biophysical research communications

authors： Kim J,Lee KM,Park CS,Park WJ

更新日期：2014-05-16 00:00:00

abstract：:Reverse cholesterol transport (RCT) plays an important role in cholesterol and lipid metabolism. Regulating the activities of key transporters and receptors in RCT, such as ATP-binding cassette transporter A1 (ABCA1), helps to prevent atherosclerotic cardiovascular disease. In this study, we used an ABCA1 promoter luc...

journal_title：Biochemical and biophysical research communications

authors： Wang X,Luo J,Li N,Liu L,Han X,Liu C,Zuo X,Jiang X,Li Y,Xu Y,Si S

更新日期：2018-09-26 00:00:00

abstract：:When cultures of Gibberella fujikuroi are incubated with 24-epiiminolanosterol the introduction of a methyl group into sterol side chains at C-24 is blocked inducing a mycelial accumulation of lanosterol and 24-desalkylsterols, i.e., having the cholestane side chain. The altered sterol composition lead to aberrant myc...

journal_title：Biochemical and biophysical research communications

authors： Nes WD,Hanners PK,Parish EJ

更新日期：1986-09-14 00:00:00

abstract：:Mutations in collagen II are associated with spondyloepiphyseal dysplasia, a group of heritable diseases whose common features include aberrations of skeletal growth. The mechanisms through which mutations in collagen II affect the cartilaginous tissues are complex and include both intracellular and extracellular proc...

journal_title：Biochemical and biophysical research communications

authors： Gawron K,Jensen DA,Steplewski A,Fertala A

更新日期：2010-05-28 00:00:00

abstract：:AMP-activated protein kinase (AMPK) is a master metabolic regulator, and is an important target for drug development against diabetes, obesity, and other diseases. AMPK is a hetero-trimeric enzyme, with a catalytic (alpha) subunit, and two regulatory (beta and gamma) subunits. Here we report the crystal structure at 2...

journal_title：Biochemical and biophysical research communications

authors： Rudolph MJ,Amodeo GA,Bai Y,Tong L

更新日期：2005-12-02 00:00:00

abstract：:Isolated brush-border membrane vesicles prepared from human placenta are known to transport amino acids via a Na+-dependent mechanism akin to that found in gut and kidney vesicle preparations. We studied sulfate transport in placental vesicles and failed to identify any Na+-dependent uptake mechanism. Rather, uptake i...

journal_title：Biochemical and biophysical research communications

authors： Cole DE

更新日期：1984-08-30 00:00:00

abstract：:Cyclooxygenase-2 (COX-2) expression is increased by hypertonicity. Therefore we hypothesized that hypertonicity increased PGE(2) can modulate the sodium transporters (Na(+)/K(+)-ATPase: NKA, epithelial sodium channel: ENaC, and sodium hydrogen exchanger: NHE) in M1 cortical collecting duct (CCD) cells. We demonstrated...

journal_title：Biochemical and biophysical research communications

authors： Nasrallah R,Paris G,Hébert RL

更新日期：2012-02-10 00:00:00

abstract：:Steatosis is an important clinical manifestation of hepatitis C virus (HCV) infection. The molecular mechanisms of HCV-associated steatosis are not well understood. Sterol regulatory element-binding protein-1c (SREBP-1c) is a key transcription factor which activates the transcription of lipogenic genes. Here we showed...

journal_title：Biochemical and biophysical research communications

authors： Xiang Z,Qiao L,Zhou Y,Babiuk LA,Liu Q

更新日期：2010-11-19 00:00:00

abstract：:Mutations in the GDD1 gene cause gnathodiaphyseal dysplasia, a rare human skeletal syndrome with autosomal dominant inheritance. The biochemical function(s) of GDD1 protein and the molecular pathophysiology of GDD1 mutations leading to GDD have not yet been elucidated. In this study, we characterized the complete cDNA...

journal_title：Biochemical and biophysical research communications

authors： Tsutsumi S,Inoue H,Sakamoto Y,Mizuta K,Kamata N,Itakura M

更新日期：2005-06-17 00:00:00

abstract：:Kinetic analyses were performed to understand the mechanism of hyperoxic induced inhibition of prostacyclin synthesis by human umbilical arteries. Brief exposure of arterial segments to oxygen resulted in over 30% decrease in Vmax of cyclooxygenase in treated vessels. In contrast, cyclooxygenase from hypoxic arterial ...

journal_title：Biochemical and biophysical research communications

authors： Yamaja Setty BN,Walenga RW,Stuart MJ

更新日期：1984-11-30 00:00:00

abstract：:We have partially characterized the properties of a specific acetylhydrolase in plasma from spontaneous hypertensive rats. This enzyme inactivates 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (a lipid involved in platelet aggregating, hypotensive, and allergic responses) by removal of the acetate group. The extent of ...

journal_title：Biochemical and biophysical research communications

authors： Blank ML,Hall MN,Cress EA,Snyder F

更新日期：1983-06-15 00:00:00

abstract：:We have characterized genomic structure and transcription of a murine odorant receptor (OR) gene, MOR23. This gene has two distinct transcriptional initiation regions, which are differentially utilized in the olfactory and testicular cells. We have found that the MOR23 gene has an intron within the 5'-untranslated reg...

journal_title：Biochemical and biophysical research communications

authors： Asai H,Kasai H,Matsuda Y,Yamazaki N,Nagawa F,Sakano H,Tsuboi A

更新日期：1996-04-16 00:00:00

abstract：:Protein, mRNA and activity levels of the calcium-independent protein kinase C (nPKC) isoenzymes were examined in NG108-15 cells. Western blot analyses reveal that proliferating NG 108-15 cells express the delta, epsilon, and eta, but not the theta species. The atypical species PKC zeta was also detected. Differentiati...

journal_title：Biochemical and biophysical research communications

authors： Battaini F,Pascale A,Lucchi L,Racchi M,Bergamaschi S,Parenti M,Wetsel WC,Govoni S,Trabucchi M

更新日期：1994-09-30 00:00:00

abstract：:RhoD is a member of the classical Rho GTPases and it has an essential role in the regulation of actin dynamics. Furthermore, RhoD also localizes to early endosomes and recycling endosomes, indicating additional roles in the regulation of endosome trafficking. A yeast two-hybrid screen identified Zipper-Interacting Pro...

journal_title：Biochemical and biophysical research communications

authors： Nehru V,Almeida FN,Aspenström P

更新日期：2013-04-05 00:00:00

abstract：:Kinetics measurements of the electron transfer between ferricytochrome c and liposomal ferrocytochrome c1 (with and without the hinge protein) were performed. The observed rate constants(kobs) of electron transfer between liposomal ferrocytochrome c1 and ferricytochrome c at different ionic strengths were measured in ...

journal_title：Biochemical and biophysical research communications

authors： Kim CH,King TE,Balny C

更新日期：1989-08-30 00:00:00

abstract：:The physical and catalytic properties of 5 histidine-serine mutants of human 5-lipoxygenase (5-LO) have been characterized. The mutants HS363, HS391 and HS400 have activities, pH optima and stabilities similar to those of the wild type enzyme. The iron content of each of these mutants is 0.30-0.53 mol Fe/mol 5-LO whic...

journal_title：Biochemical and biophysical research communications

authors： Percival MD,Ouellet M

更新日期：1992-08-14 00:00:00

abstract：:The biological significance of isoprenoid compounds such as ubiquinones, prenols and sterols have been well established. The presence and biological function of the two quinones Q6 and Q8 in the cattle filarial parasite Setaria digitata have already been reported. Inhibition of the function of quinone was already show...

journal_title：Biochemical and biophysical research communications

authors： Kumari GA,Santhamma KR,Raj RK

更新日期：1994-11-30 00:00:00

abstract：:Multiple system atrophy is a neurodegenerative disease caused by abnormal α-synuclein (α-syn) accumulation in oligodendrocytes and neurons. We previously demonstrated that transgenic (Tg) mice that selectively overexpressed human α-syn in oligodendrocytes exhibited neuronal α-syn accumulation. Microtubule β-III tubuli...

journal_title：Biochemical and biophysical research communications

authors： Ito H,Nakayama K,Jin C,Suzuki Y,Yazawa I

更新日期：2012-11-23 00:00:00

abstract：:The abilities of FK506 and rapamycin to block distinct signal transduction pathways are mediated by soluble binding proteins. Previously, a family of these receptors has been recognized that includes a 25 kDa protein, FKBP25. We now report the isolation of a cDNA for FKBP25 from a human hippocampal cDNA library by oli...

journal_title：Biochemical and biophysical research communications

authors： Hung DT,Schreiber SL

更新日期：1992-04-30 00:00:00

abstract：:Intracellular Ca2+ oscillations in fertilized mammalian eggs, the key signal that stimulates egg activation and early embryonic development, are regulated by inositol 1,4,5-trisphosphate (IP3) signaling pathway. We investigated temporal changes in intracellular IP3 concentration ([IP3]i) in mouse eggs, using a fluores...

journal_title：Biochemical and biophysical research communications

authors： Shirakawa H,Ito M,Sato M,Umezawa Y,Miyazaki S

更新日期：2006-06-30 00:00:00

abstract：:The dodecapeptide MCLV3 is a functional peptide, derived from the CLV3 precursor protein, which is a candidate ligand of the CLV1/CLV2 receptor complex that restricts the stem cell population in the shoot apical meristem (SAM). MCLV3 can induce shoot and root meristem consumption, the typical phenotype of transgenic p...

journal_title：Biochemical and biophysical research communications

authors： Kondo T,Nakamura T,Yokomine K,Sakagami Y

更新日期：2008-12-05 00:00:00

abstract：:After allylisopropylacetamide-mediated "suicide" destruction of their prosthetic heme moieties, certain rat liver cytochrome P-450 isozymes can be effectively reconstituted by addition of exogenous hemin in vitro. We now report that two of these isozymes will equally accept mesohemin , a 2,4-diethyl heme-analog and re...

journal_title：Biochemical and biophysical research communications

authors： Bornheim LM,Correia MA,Smith KM

更新日期：1984-05-31 00:00:00

abstract：:Cytoglobin is a recently discovered myoglobin-related O2-binding protein of vertebrates with uncertain function. It occurs as single-copy gene in mammals. Here, we demonstrate the presence of two paralogous cytoglobin genes (Cygb-1 and Cygb-2) in the teleost fishes Danio rerio, Oryzias latipes, Tetraodon nigroviridis,...

journal_title：Biochemical and biophysical research communications

authors： Fuchs C,Luckhardt A,Gerlach F,Burmester T,Hankeln T

更新日期：2005-11-11 00:00:00

abstract：:The acyclic nucleotide analogue (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine [(S)-HPMPA] is a potent and selective inhibitor of African swine fever virus (ASFV) replication. Using the DNA-DNA hybridization technique with plasmid pRPEL-2 as probe, we have shown that (S)-HPMPA exerts a specific, dose-dependent, in...

journal_title：Biochemical and biophysical research communications

authors： Arzuza O,García-Villalón D,Tabarés E,Gil-Fernández C,De Clercq E

更新日期：1988-07-15 00:00:00

abstract：:Expression of ALP in F9 teratocarcinoma cells is induced by all-trans retinoic acid (ATRA) (Gianni' et al., Biochem. J. 274: 673-678, 1991). The specific ligand for retinoic acid related receptors (RXRs), 9-cis retinoic acid (9-cis RA), and three synthetic analogs binding to the alpha, beta and gamma forms of the reti...

journal_title：Biochemical and biophysical research communications

authors： Gianni M,Zanotta S,Terao M,Garattini S,Garattini E

更新日期：1993-10-15 00:00:00

abstract：:The IGF-I receptor binds IGF-I with complex kinetics characterized by a curvilinear Scatchard plot, suggesting receptor heterogeneity and apparent negative cooperativity. To explore the molecular mechanisms underlying these properties, we have characterized the binding of a hybrid receptor formed from a wild-type rece...

journal_title：Biochemical and biophysical research communications

authors： Chakravarty A,Hinrichsen J,Whittaker L,Whittaker J

更新日期：2005-05-27 00:00:00

abstract：:Eicosapentaenoic acid (EPA; 20:5 n-3; ethyl ester) in combination with atherogenic or non-atherogenic high fat diets was fed to young adult male marmoset monkeys for a period of 30 weeks. EPA markedly reduced the raised plasma cholesterol level evident when feeding an atherogenic diet but did not influence the cardiac...

journal_title：Biochemical and biophysical research communications

authors： Patten GS,Rinaldi JA,McMurchie EJ

更新日期：1989-07-31 00:00:00