Abstract:
:microRNAs (miRNAs) are frequently dysregulated in human malignancies. It was recently shown that miR-204-5p is downregulated in papillary thyroid carcinoma (PTC); however, the functional significance of this observation is not known. This study investigated the role of miR-204-5p in PTC. Overexpressing miR-204-5p suppressed PTC cell proliferation and induced cell cycle arrest and apoptosis. The results of a luciferase reporter assay showed that miR-204-5p can directly bind to the 3' untranslated region (UTR) of insulin-like growth factor-binding protein 5 (IGFBP5) mRNA, and IGFBP5 overexpression partially reversed the growth-inhibitory effects of miR-204-5p. These results indicate that miR-204-5p acts as a tumor suppressor in PTC by regulating IGFBP5 expression and that miR-204-5p can potentially serve as an antitumorigenic agent in the treatment of PTC.
journal_name
Biochem Biophys Res Communjournal_title
Biochemical and biophysical research communicationsauthors
Liu L,Wang J,Li X,Ma J,Shi C,Zhu H,Xi Q,Zhang J,Zhao X,Gu Mdoi
10.1016/j.bbrc.2015.01.037subject
Has Abstractpub_date
2015-02-20 00:00:00pages
621-6issue
4eissn
0006-291Xissn
1090-2104pii
S0006-291X(15)00059-5journal_volume
457pub_type
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