Distinct role of the intracellular C-terminus for subcellular expression, shedding and function of the murine transmembrane chemokine CX3CL1.

Abstract:

:The transmembrane chemokine CX3CL1 is expressed on the endothelial surface and promotes leukocyte adhesion and transmigration by receptor interaction via its extracellular chemokine domain. Since little is known about its intracellular C-terminus, we examined the consequences of C-terminal truncation on cellular distribution, proteolytic shedding and function of murine CX3CL1. Full length murine CX3CL1 was expressed and shed by the metalloproteinase ADAM10 as described for human CX3CL1. Truncation of murine CX3CL1 led to reduced maturation and impaired trafficking to the surface. Truncation of CX3CL1 also abrogated localization to early endosomal vesicles, but increased shedding from the surface by ADAM10. Once truncated CX3CL1 was expressed on the surface, it mediated cell contact and induced leukocyte transmigration similar as full length CX3CL1. These data suggest that the C-terminus of CX3CL1 carries important determinants for cellular trafficking but not for function of the chemokine during leukocyte recruitment.

authors

Andrzejewski MG,Koelsch A,Kogel T,Dreymueller D,Schwarz N,Ludwig A

doi

10.1016/j.bbrc.2010.03.139

subject

Has Abstract

pub_date

2010-04-30 00:00:00

pages

178-84

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(10)00614-5

journal_volume

395

pub_type

杂志文章
  • Identification of a novel seven-transmembrane receptor with homology to glycoprotein receptors and its expression in the adult and developing mouse.

    abstract::Using a PCR-based cloning strategy we have isolated a cDNA from mouse brain and named it fex, because it codes for a novel putative G protein-coupled receptor expressed in follicles. The deduced amino acid sequence shows a higher degree of homology to the family of glycoprotein receptors, namely those for FSH, LH, and...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1006/bbrc.1998.9882

    authors: Hermey G,Methner A,Schaller HC,Hermans-Borgmeyer I

    更新日期:1999-01-08 00:00:00

  • In vitro display evolution of the PURE system-expressed TNFα-binding unnatural cyclic peptide containing an N-methyl-d-amino acid.

    abstract::Tumor necrosis factor-alpha (TNFα) is a multifunctional cytokine associated with inflammation, immune responses, and autoimmune diseases including rheumatoid arthritis, inflammatory bowel disease, and psoriasis. In the present study, we performed in vitro selection, systematic evolution of ligands by exponential enric...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2020.11.050

    authors: Tsukamoto K,Ando T,Fuji D,Yokoyama T,Takamori Y,Horiuchi D,Iwamoto R,Yamamoto M,Kawakami T

    更新日期:2021-01-01 00:00:00

  • Analysis of an intronic promoter within Synj2.

    abstract::Synj2 (synaptojanin 2) encodes an inositol polyphosphate phosphatase that functions in recycling neurotransmitter vesicles and is implicated in spermatogenesis. Transcription of Synj2 is thought to occur from one of two promoters based on analysis of a variable 5' untranslated region. Clustering all known mouse Synj2 ...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2013.09.115

    authors: Planchart A

    更新日期:2013-11-01 00:00:00

  • 1H NMR-based metabolomic study on resistance to diet-induced obesity in AHNAK knock-out mice.

    abstract::AHNAK is a giant protein of approximately 700 kDa identified in human neuroblastomas and skin epithelial cells. Recently, we found that AHNAK knock-out (AHNAK(-/-)) mice have a strong resistance to high-fat diet-induced obesity. In this study, we applied (1)H NMR-based metabolomics with multivariate statistical analys...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2010.11.048

    authors: Kim IY,Jung J,Jang M,Ahn YG,Shin JH,Choi JW,Sohn MR,Shin SM,Kang DG,Lee HS,Bae YS,Ryu DH,Seong JK,Hwang GS

    更新日期:2010-12-17 00:00:00

  • Crystal structure of the Rasputin NTF2-like domain from Drosophila melanogaster.

    abstract::The crystal structure of the NTF2-like domain of the Drosophila homolog of Ras GTPase SH3 Binding Protein (G3BP), Rasputin, was determined at 2.7Å resolution. The overall structure is highly similar to nuclear transport factor 2: It is a homodimer comprised of a β-sheet and three α-helices forming a cone-like shape. H...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2012.02.140

    authors: Vognsen T,Kristensen O

    更新日期:2012-03-30 00:00:00

  • Sox9 mediated transcriptional activation of FOXK2 is critical for colorectal cancer cells proliferation.

    abstract::FOXK2, which belongs to the fork head DNA binding protein family, has been shown to play a critical role in tumorigenesis. Here, we detected FOXK2 expression and its clinical significance in colorectal cancer, which has not been fully investigated before. Results from public database and our cohort indicated that FOXK...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2016.12.119

    authors: Qian Y,Xia S,Feng Z

    更新日期:2017-01-29 00:00:00

  • Low false positive and accurate detection of yeast cell viability and concentration using an automatic staining and lensfree imaging platform.

    abstract::Yeast cell viability and concentration are the crucial factors affecting product quality in food industry and bio-fuel production, as well as the evaluation basis for environmental toxic compounds. To overcome the drawbacks of existing methods, including high error, false positive and low automation, we propose a high...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2020.02.155

    authors: Li G,Wei M,Sun J,Zhang Y,Zhang R

    更新日期:2020-05-07 00:00:00

  • Expression and characterization of recombinant kurtoxin, an inhibitor of T-type voltage-gated calcium channels.

    abstract::Kurtoxin, a 63-amino acid peptide stabilized by four disulfide bonds, is the first reported peptide inhibitor of T-type voltage-gated calcium channels. Although T-type calcium channels have been implicated in a number of disease states, including epilepsy, chronic pain, hypertension and cancer, the lack of selective i...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2011.11.003

    authors: Lee CW,Eu YJ,Min HJ,Cho EM,Lee JH,Kim HH,Nah SY,Swartz KJ,Kim JI

    更新日期:2011-12-16 00:00:00

  • Cellular and molecular biology of prostacyclin synthase.

    abstract::Prostacyclin synthase (PGIS) cDNA comprises 1500 nucleotides coding for a 500 amino acid protein. It is a heme protein with spectral characteristics of cytochrome p450 (CYP). It does not possess the typical CYP mono-oxygenase activity but catalyzes the rearrangement of prostaglandin H2 to form PGI2. Analysis of its st...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章,评审

    doi:10.1016/j.bbrc.2005.08.021

    authors: Wu KK,Liou JY

    更新日期:2005-12-09 00:00:00

  • Direct interaction between a quinoline derivative, MS-209, and multidrug resistance protein (MRP) in human gastric cancer cells.

    abstract::MS-209 is a novel quinoline derivative reversing P-glycoprotein-mediated multidrug resistance (MDR). We investigated the interaction between MS-209 and multidrug resistance protein (MRP) in MRP-overexpressing human gastric cancer cells. We measured [3H]leukotriene C4 uptake into the membrane vesicles of the cells and ...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1006/bbrc.1999.0245

    authors: Nakamura T,Oka M,Aizawa K,Soda H,Fukuda M,Terashi K,Ikeda K,Mizuta Y,Noguchi Y,Kimura Y,Tsuruo T,Kohno S

    更新日期:1999-02-24 00:00:00

  • Synthesis and in vitro bioactivity of C-terminal deleted analogs of human growth hormone-releasing factor.

    abstract::A series of C-terminal deleted analogs of human growth hormone-releasing factor (hGRF) with either an amidated or a free carboxylic acid C-terminus were synthesized by solid phase methodology. Their capacity to release growth hormone was tested on rat anterior pituitary cells in monolayer culture. A gradual decrease o...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/0006-291x(84)90309-7

    authors: Ling N,Baird A,Wehrenberg WB,Ueno N,Munegumi T,Brazeau P

    更新日期:1984-09-17 00:00:00

  • Uniform amplification of multiple DNAs by emulsion PCR.

    abstract::When several DNAs are amplified by PCR in one PCR tube, biased amplification is known to occur because amplification efficiency differs from one DNA to another. Therefore, we conducted PCR in the water in oil-emulsion (W/O emulsion) to examine whether the procedure allows the uniform amplification of several DNAs. In ...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2006.11.037

    authors: Hori M,Fukano H,Suzuki Y

    更新日期:2007-01-12 00:00:00

  • Spectra of chloroperoxidase compounds II and III.

    abstract::Chloroperoxidase was present as Compound II during the peroxidatic oxidation of ascorbic acid. Compound III (oxy-form) was formed when excess hydrogen peroxide was added to Compound II. By decreasing the temperature it was possible to measure the spectra of Compounds II and III in the Soret and visible regions. Each s...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/0006-291x(85)91635-3

    authors: Nakajima R,Yamazaki I,Griffin BW

    更新日期:1985-04-16 00:00:00

  • Detection of total DNA with single-stranded DNA binding protein conjugates.

    abstract::We have developed a rapid and sensitive method for total DNA measurement using single-stranded DNA binding protein from E coli conjugated with horseradish peroxidase or urease. To detect DNA, the sample is heated or alkali treated to denature the DNA and then filtered through nylon or nitrocellulose membranes. After t...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/0006-291x(89)91094-2

    authors: Sheldon EL 3rd,Nagainis PA,Kung VT

    更新日期:1989-11-30 00:00:00

  • Effects of leptin on HPG axis and reproductive function in male rat in simulated altitude of 5500 m hypoxia environment.

    abstract::High altitude hypobaric hypoxia environment impairs male's reproductive function. Leptin is an adipose tissue-derived hormone which regulates body weight homeostasis. Its receptor (LepR) has been found in all levels of male reproductive axis, indicating that it can affect male reproductive system in a direct or (and) ...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2020.05.194

    authors: Liu X,Liu S,Xu C

    更新日期:2020-08-13 00:00:00

  • Antiviral potency of adenosine analogues: correlation with inhibition of S-adenosylhomocysteine hydrolase.

    abstract::For a series of adenosine analogues a close correlation (r = 0.986) was found between their antiviral potency (against vesicular stomatitis virus) and their inhibitory effects (Ki/Km) on S-adenosylhomocysteine (AdoHcy) hydrolase; thus, in order of increasing inhibitory potency for both virus replication and AdoHcy hyd...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/0006-291x(85)91438-x

    authors: De Clercq E,Cools M

    更新日期:1985-05-31 00:00:00

  • Solution structure of human steroidogenic acute regulatory protein STARD1 studied by small-angle X-ray scattering.

    abstract::Intracellular cholesterol transfer to mitochondria, a bottleneck of adrenal and gonadal steroidogenesis, relies on the functioning of the steroidogenic acute regulatory protein (StAR, STARD1), for which many disease-associated mutations have been described. Despite significant progress in the field, the exact mechanis...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2017.05.167

    authors: Sluchanko NN,Tugaeva KV,Maksimov EG

    更新日期:2017-08-05 00:00:00

  • The kinetics and magnesium requirements for the folding of antigenomic delta ribozymes.

    abstract::Using an oligonucleotide hybridization assay to gain insight into the folding of delta ribozymes, we demonstrate a correlation between their folding and catalytic behavior. Together with recent structural information on the crystal structure of self-cleaved genomic delta ribozyme, in which the L3 loop interacts with J...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1006/bbrc.2000.2465

    authors: Ananvoranich S,Perreault JP

    更新日期:2000-04-13 00:00:00

  • Calmodulin regulation of cholinergic muscarinic receptor: effects of calcium and phosphorylating states.

    abstract::Calmodulin (CaM) regulation of cholinergic muscarinic receptor was investigated using synaptic membrane isolated from rat brains and [3H]-QNB as a binding ligand. CaM exerts a biphasic effect on receptor binding showing both a Ca2+-dependent receptor loss and an increase depending on the state of membrane phosphorylat...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/0006-291x(85)91263-x

    authors: Ho AK,Wang JH

    更新日期:1985-12-31 00:00:00

  • Low density lipoprotein (LDL) inhibits histamine release from human mast cells.

    abstract::We examined the effect of low density lipoprotein (LDL) on histamine release from purified human lung mast cells. LDL inhibited anti-IgE- induced histamine release in a dose-dependent manner, with 100 micrograms/ml LDL-protein inhibiting histamine release by 53 +/- 8% (mean +/- SEM); half-maximal inhibition occurred a...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/0006-291x(87)90912-0

    authors: Schulman ES,Quinn TJ,Post TJ,O'Donnell P,Rodriguez A,Gonen B

    更新日期:1987-10-29 00:00:00

  • Picrotoxin is a CYP1A1 inducer in rainbow trout hepatocytes.

    abstract::Picrotoxin is a CYP2B inducer in mammals (1). However, in primary cultures of rainbow trout hepatocytes we showed CYP1A1 gene expression to be strongly induced as characterized by 7-ethoxyresorufin-O-deethylase activity, immunoblots of CYP1A1 protein, and Northern blots of CYP1A1 mRNA. Induction of CYP1A1 in these cel...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1006/bbrc.1995.2393

    authors: Sadar MD,Ash R,Andersson TB

    更新日期:1995-09-25 00:00:00

  • Direct observations of the redox states of frozen cherry buds by a unique in vivo ESR.

    abstract::Low temperatures cause cellular damage in flower buds of the sweet cherry (Prunus avium L. cv. Satohnishiki). In this study, the redox states within the cherry buds suffering freezing damage were non-destructively observed by a unique in vivo electron spin resonance (ESR) technique with a spin probe such as carbamoyl-...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2003.08.123

    authors: Tada M,Shiraishi T,Takashina T,Ohya H,Ogata T

    更新日期:2003-10-10 00:00:00

  • Long non-coding RNA GClnc1 promotes tumorigenesis in osteosarcoma by inhibiting p53 signaling.

    abstract::Recent studies suggest important roles for long noncoding RNAs as essential regulators of human cancer. GClnc1 was found to be upregulated in gastric cancer, playing oncogenic roles. However, the biological function and underlying mechanism of GClnc1 in osteosarcoma (OS) remain unclear. Here, we report that GClnc1 is ...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2018.10.135

    authors: Sui Y,Han Y,Zhao X,Li D,Li G

    更新日期:2018-12-09 00:00:00

  • Monoclonal antibodies against beta-galactoside-binding lectin of chick embryo recognizes conformational change of the antigen.

    abstract::Monoclonal antibodies against chick embryonic beta-galactoside-binding lectin were obtained. One of the monoclonal antibodies was ineffective in Western blotting and seemed to be unable to bind the SDS-denatured lectin. When the native lectin was dotted on a nitrocellulose filter and subjected to denaturation by treat...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/s0006-291x(84)80257-0

    authors: Oda Y,Kasai K

    更新日期:1984-09-28 00:00:00

  • ATP binding to two sites is necessary for dimerization of nucleotide-binding domains of ABC proteins.

    abstract::ATP binding cassette (ABC) transporters have a functional unit formed by two transmembrane domains and two nucleotide binding domains (NBDs). ATP-bound NBDs dimerize in a head-to-tail arrangement, with two nucleotides sandwiched at the dimer interface. Both NBDs contribute residues to each of the two nucleotide-bindin...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2013.11.050

    authors: Zoghbi ME,Altenberg GA

    更新日期:2014-01-03 00:00:00

  • Trafficking of cGMP-dependent protein kinase II via interaction with Rab11.

    abstract::cGMP-dependent protein kinase II (cGK-II) is implicated in several physiological functions including intestinal secretion, bone growth, and learning and memory, but the detailed mechanisms are still unclear. To identify proteins that are involved in cGMP/cGK-II signaling, we performed yeast two-hybrid screening and id...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2008.07.071

    authors: Yuasa K,Yamagami S,Nagahama M,Tsuji A

    更新日期:2008-09-26 00:00:00

  • Hypertonicity increases sodium transporters in cortical collecting duct cells independently of PGE2.

    abstract::Cyclooxygenase-2 (COX-2) expression is increased by hypertonicity. Therefore we hypothesized that hypertonicity increased PGE(2) can modulate the sodium transporters (Na(+)/K(+)-ATPase: NKA, epithelial sodium channel: ENaC, and sodium hydrogen exchanger: NHE) in M1 cortical collecting duct (CCD) cells. We demonstrated...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2012.01.028

    authors: Nasrallah R,Paris G,Hébert RL

    更新日期:2012-02-10 00:00:00

  • Inhibition of the acetyl lysine-binding pocket of bromodomain and extraterminal domain proteins interferes with adipogenesis.

    abstract::The bromodomain and extraterminal (BET) domain family proteins are epigenetic modulators involved in the reading of acetylated lysine residues. The first BET protein inhibitor to be identified, (+)-JQ1, a thienotriazolo-1, 4-diazapine, binds selectively to the acetyl lysine-binding pocket of BET proteins. We evaluated...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/j.bbrc.2016.03.013

    authors: Goupille O,Penglong T,Kadri Z,Granger-Locatelli M,Fucharoen S,Maouche-Chrétien L,Prost S,Leboulch P,Chrétien S

    更新日期:2016-04-15 00:00:00

  • Compound heterozygous mutations affecting both hepatic and erythrocyte isozymes of pyruvate kinase.

    abstract::Novel erythrocyte pyruvate kinase gene defects were found in a patient without a family history of consanguinity. The polymerase chain reaction products of the R-type pyruvate kinase cDNA from the propositus contained two point mutations of Ser80 (TCC)-->Pro (CCC) and Arg490 (CGG)-->Trp (TGG). Allele-specific polymera...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1006/bbrc.1995.1432

    authors: Uenaka R,Nakajima H,Noguchi T,Imamura K,Hamaguchi T,Tomita K,Yamada K,Kuwajima M,Kono N,Tanaka T

    更新日期:1995-03-28 00:00:00

  • A pancreatic-type phospholipase A2 in rat gastric mucosa.

    abstract::A phospholipase A2, which is immuno-crossreactive with the anti-rat pancreatic phospholipase A2 antibody, is present in rat gastric mucosa. The content of the enzyme in the gastric mucosa was comparable to that in the pancreas, but the specific activity in the gastric mucosa homogenate (60.7 +/- 19.5 nmol/min/mg) was ...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章

    doi:10.1016/s0006-291x(88)80491-1

    authors: Tojo H,Ono T,Okamoto M

    更新日期:1988-03-30 00:00:00