Cathepsin Q, a novel lysosomal cysteine protease highly expressed in placenta.

abstract：:GLP-1 can help to overcome problems of liver cells metabolism, not only pancreatic cell. But the explicit mechanism of this effect remains unclear. In recent years, microRNAs have received the attention of researchers and some microRNAs have important implications for diabetes. The mitochondrial protective gene PGC-1α...

journal_title：Biochemical and biophysical research communications

authors： Wang C,Li Q,Wang W,Guo L,Guo C,Sun Y,Zhang J

更新日期：2015-10-09 00:00:00

abstract：:Cot/Tpl2, a member of MAP kinase kinase kinase (MAPKKK), is indispensable for the ERK activation, as well as the production of TNF-α, IL-1β, IL-23, and PGE(2) in lipopolysaccharide (LPS)-stimulated macrophages. However, the expression and the functional roles of Cot/Tpl2 in mast cells have not been elucidated. The adm...

journal_title：Biochemical and biophysical research communications

authors： Chiba N,Kakimoto K,Masuda A,Matsuguchi T

更新日期：2010-11-05 00:00:00

abstract：:Cell to cell interaction in bone marrow is crucial for differentiation of hematopoietic cells. We have shown that EphB4 receptor is expressed in erythroid progenitor and its activation accelerates erythroid differentiation. To elucidate the role of EphB4 activation in erythropoiesis, we analyzed effects of EphB4 on ce...

journal_title：Biochemical and biophysical research communications

authors： Sakamoto H,Zhang XQ,Suenobu S,Ohbo K,Ogawa M,Suda T

更新日期：2004-08-27 00:00:00

abstract：:The self-induced endogenous elicitor isolated from potato having molecular weight 9200 was degraded with trifluoroacetic acid to determine the sugar composition. The requisite composition of the elicitor was estimated to be a 2:3:4:7 mixture of galactose, rhamnose, arabinose, and galacturonic acid. Furthermore, the st...

journal_title：Biochemical and biophysical research communications

authors： Monden T,Nakamura H,Murai A

更新日期：1995-10-13 00:00:00

abstract：:Lafora disease, a progressive myoclonus epilepsy, is an autosomal recessive disease caused in approximately 80% of cases by mutation of the EPM2A gene, which encodes a dual specificity protein phosphatase called laforin. In addition to its phosphatase domain, laforin contains an N-terminal carbohydrate-binding domain ...

journal_title：Biochemical and biophysical research communications

authors： Wang W,Roach PJ

更新日期：2004-12-17 00:00:00

abstract：:Recently, the concern that toluene might have carcinogenic and reproductive toxic potential has been raised. We investigated the ability of DNA damage by minor metabolites of toluene, methylhydroquinone, and methylbenzoquinone, using (32)P-5'-end-labeled DNA fragments obtained from the human genes. Methylhydroquinone ...

journal_title：Biochemical and biophysical research communications

authors： Murata M,Tsujikawa M,Kawanishi S

更新日期：1999-08-02 00:00:00

abstract：:Aminoglycosides are important antibiotics used against a wide range of pathogens. As a mechanism of defense, bacteria have evolved enzymes able to inactivate these drugs by regio-selectively adding a variety of functionalities (acetyl, phospho, and nucelotidyl groups) to their scaffolds. The aminoglycoside nucleotidyl...

journal_title：Biochemical and biophysical research communications

authors： Porter VR,Green KD,Zolova OE,Houghton JL,Garneau-Tsodikova S

更新日期：2010-12-03 00:00:00

abstract：:Patient-derived xenografts (PDXs) are widely recognised as a more physiologically relevant preclinical model than standard cell lines, but are expensive and low throughput, have low engraftment rate and take a long time to develop. Our newly developed conditional reprogramming (CR) technology addresses many PDX drawba...

journal_title：Biochemical and biophysical research communications

authors： Mondal AM,Ma AH,Li G,Krawczyk E,Yuan R,Lu J,Schlegel R,Stamatakis L,Kowalczyk KJ,Philips GK,Pan CX,Liu X

更新日期：2019-09-10 00:00:00

abstract：:We previously showed that beta-defensin-1 (BD-1), an anti-microbial peptide, is up-regulated during progressive hyperglycemia in the kidneys of the GK rat [R.A. Page, C.A. Morris, J.D. Williams, C.J. von Ruhland, A.N. Malik, Isolation of diabetes-associated kidney genes using differential display, Biochem. Biophys. Re...

journal_title：Biochemical and biophysical research communications

authors： Malik AN,Al-Kafaji G

更新日期：2007-02-09 00:00:00

abstract：:To investigate the effect of ionophores on Cl- distribution in human erythrocyte suspensions, we measured the membrane potential by using 19F and 31P NMR methods. Incubation of human erythrocytes with 0.005 mM of the neutral ionophores valinomycin and nonactin resulted in membrane potentials of -21.2 and -17.8 mV in t...

journal_title：Biochemical and biophysical research communications

authors： Wittenkeller L,Mota de Freitas D,Ramasamy R

更新日期：1992-04-30 00:00:00

abstract：:The relationship between vascular tone and the induction by endotoxin of a nitric oxide (NO) synthase was studied in vitro in rings of rat thoracic aorta. In rings with and without endothelium there was a time-dependent induction of NO synthase accompanied by both spontaneous and L-arginine-induced relaxation and by r...

journal_title：Biochemical and biophysical research communications

authors： Rees DD,Cellek S,Palmer RM,Moncada S

更新日期：1990-12-14 00:00:00

abstract：:Profilin, an actin-binding protein, was previously described as a ubiquitous allergen which is responsible for cross-reactivities in about 20% of pollen and food allergic patients. A complete cDNA clone coding for timothy grass (Phelum pratense) pollen profilin was isolated using allergic patients IgE. The deduced ami...

journal_title：Biochemical and biophysical research communications

authors： Valenta R,Ball T,Vrtala S,Duchêne M,Kraft D,Scheiner O

更新日期：1994-02-28 00:00:00

abstract：:We developed a modified method enabling stable MALDI-MS analysis and fluorescent detection of sialyl-compounds. The modification involved the amidation of sialic acid (Neu5Ac) at the position of the carboxyl group using the fluorescent reagent, 2-(2-pyridilamino)ethylamine (PAEA). In this study the following sialyl-co...

journal_title：Biochemical and biophysical research communications

authors： Endo S,Morita M,Ueno M,Maeda T,Terabayashi T

更新日期：2009-01-23 00:00:00

abstract：:Electrofocusing of mouse small intestine mucosal cytosol yielded two prominent peaks of glutathione S-transferase activity, at pH 8.7 and pH 9.0. These intestinal transferases were indistinguishable from corresponding liver transferases in immunological reactivities and in several other properties. Dietary t-butyl-4-h...

journal_title：Biochemical and biophysical research communications

authors： Parchment RE,Benson AM

更新日期：1984-03-30 00:00:00

abstract：:Inflammation has an essential role in regulating the pathogenesis of acute respiratory distress syndrome (ARDS). The serine/threonine kinase PIM2 is highly expressed in human macrophages, and exhibits regulatory role in inflammatory response. However, its effect on ARDS progression has not been investigated and still ...

journal_title：Biochemical and biophysical research communications

authors： Wang F,Xu L,Dong G,Zhu M,Liu L,Wang B

更新日期：2020-12-17 00:00:00

abstract：:Factors affecting Ins(1,3,4,5)P4-mediated nuclear Ca2+ uptake are investigated, which include Ins(1,3,4,5)P4 receptor ligand specificity and free external Ca2+ concentrations. Among various inositol phosphates examined, Ins(1,3,4,5)P4, Ins(3,4,5,6)P4, and Ins(1,3,4,5,6)P5 can also stimulate 45Ca2+ influx into isolated...

journal_title：Biochemical and biophysical research communications

authors： Hsu AL,Lu PJ,Chen CS

更新日期：1998-02-24 00:00:00

abstract：:Disrupted-In-Schizophrenia 1 (DISC1) was identified as a novel gene disrupted by a (1;11)(q42.1;q14.3) translocation segregating with schizophrenia, bipolar disorder and other major mental illnesses in a Scottish family. We previously identified 446-533 amino acids of DISC1 as the kendrin-binding region by means of a ...

journal_title：Biochemical and biophysical research communications

authors： Shimizu S,Matsuzaki S,Hattori T,Kumamoto N,Miyoshi K,Katayama T,Tohyama M

更新日期：2008-12-26 00:00:00

abstract：:A homodimeric protein designated quinqueginsin, with a molecular weight of 53 kDa, has been isolated from the roots of American ginseng Panax quinquefolium. It was unadsorbed on DEAE cellulose in low ionic strength and neutral pH, and adsorbed on Affigel blue gel and SP-Sepharose under similar conditions. Its N-termin...

journal_title：Biochemical and biophysical research communications

authors： Wang HX,Ng TB

更新日期：2000-03-05 00:00:00

abstract：:Mutations in the GDD1 gene cause gnathodiaphyseal dysplasia, a rare human skeletal syndrome with autosomal dominant inheritance. The biochemical function(s) of GDD1 protein and the molecular pathophysiology of GDD1 mutations leading to GDD have not yet been elucidated. In this study, we characterized the complete cDNA...

journal_title：Biochemical and biophysical research communications

authors： Tsutsumi S,Inoue H,Sakamoto Y,Mizuta K,Kamata N,Itakura M

更新日期：2005-06-17 00:00:00

abstract：:We explored the effect of transforming growth factor beta (TGF-beta), a cytokine that appears to play a central role in inflammatory events, on albumin expression by normal adult human hepatocytes and hepatoma cells. Addition of TGF-beta to primary human hepatocyte cultures resulted in a dramatic decrease in albumin a...

journal_title：Biochemical and biophysical research communications

authors： Busso N,Chesne C,Delers F,Morel F,Guillouzo A

更新日期：1990-09-14 00:00:00

abstract：:Intracellular B(12) metabolism involves a B(12) trafficking chaperone CblC that is well conserved in mammals including human. The protein CblC is known to bind cyanocobalamin (CNCbl, vitamin B(12)) inducing the base-off transition and convert it into an intermediate that can be used in enzyme cofactor synthesis. The b...

journal_title：Biochemical and biophysical research communications

authors： Jeong J,Kim J

更新日期：2011-08-26 00:00:00

abstract：:Myocardium of mammals contains a wide range of isoforms of proteins that provides contractile function of the heart. These are two isoforms of ventricular and two of atrial myosin, α- and β-tropomyosin, and two isoforms of α-actin: cardiac and skeletal. We believe that the difference in the amino acid sequence of α-ac...

journal_title：Biochemical and biophysical research communications

authors： Shchepkin DV,Nikitina LV,Bershitsky SY,Kopylova GV

更新日期：2017-08-19 00:00:00

abstract：:A method to prepare amyloid-like fibrils functionalized with magnetic nanoparticles has been developed. The amyloid-like fibrils are prepared in a two step procedure, where insulin and magnetic nanoparticles are mixed simply by grinding in the solid state, resulting in a water soluble hybrid material. When the hybrid ...

journal_title：Biochemical and biophysical research communications

authors： Andersson BV,Skoglund C,Uvdal K,Solin N

更新日期：2012-03-23 00:00:00

abstract：:Advanced glomerulosclerosis, a common hallmark of chronic renal diseases (CRD) is believed to be irreversible, and it is thought that glomerular hyperfiltration and hypertrophy may participate in its pathogenesis. We demonstrate here that glomerulosclerosis is "reversible" in an animal model. We used nephrotic ICGN (n...

journal_title：Biochemical and biophysical research communications

authors： Mizuno-Horikawa Y,Mizuno S,Tamura S,Kurosawa T

更新日期：2001-06-15 00:00:00

abstract：:Insulin inhibits hepatic very low density lipoprotein (VLDL) apo B secretion in rats. Current studies test whether the insulin effect is LDL receptor-mediated by examining the effect of insulin on VLDL apo B secretion in hepatocytes derived from Ldlr-/- and control mice. Primary hepatocytes were incubated overnight wi...

journal_title：Biochemical and biophysical research communications

authors： Chirieac DV,Cianci J,Collins HL,Sparks JD,Sparks CE

更新日期：2002-09-13 00:00:00

abstract：:WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. The cloning and characterization of a novel human WW domain-containing gene, hWW45, which encodes a protein of app...

journal_title：Biochemical and biophysical research communications

authors： Valverde P

更新日期：2000-10-05 00:00:00

abstract：:Disruption of cell-cell adhesion, which is essential for the maintenance of epithelial plasticity and is mediated by a class of proteins called cadherins, is an initial event in the progression of cancer. Cadherins are Ca(2+)-dependent transmembrane proteins that are associated with actin via other cytoplasmic protein...

journal_title：Biochemical and biophysical research communications

authors： Baranwal S,Alahari SK

更新日期：2009-06-19 00:00:00

abstract：:Polyamine biosynthesis pathway has long been considered an essential drug target for trypanosomatids including Leishmania. S-adenosylmethionine decarboxylase (AdoMetDc) and spermidine synthase (SpdSyn) are enzymes of this pathway that catalyze successive steps, with the product of the former, decarboxylated S-adenosyl...

journal_title：Biochemical and biophysical research communications

authors： Mishra AK,Agnihotri P,Srivastava VK,Pratap JV

更新日期：2015-01-09 00:00:00

abstract：:An organoid is a complex, multi-cell three-dimensional (3D) structure that contains tissue-specific cells. Epithelial stem cells, which are marked by leucine-rich repeat-containing G-protein coupled receptor 5 (Lgr5), have the potential for self-renewal and expansion as organoids. However, in the case of intestinal or...

journal_title：Biochemical and biophysical research communications

authors： Hahn S,Kim MS,Choi SY,Jeong S,Jee J,Kim HK,Jeong SY,Shin H,Kim HS,Park JS,Yoo J

更新日期：2019-01-08 00:00:00

abstract：:When a plasmid encoding the Sleeping Beauty (SB) transposase (pCMV-SB) was cointroduced with luciferase expression plasmid DNA into mouse skeletal muscle at a molar ratio of 4:1, luciferase gene expression was 5 times higher than the expression without pCMV-SB on day 28. This enhancement was not dependent on the prese...

journal_title：Biochemical and biophysical research communications

authors： Masuda K,Yamamoto S,Endoh M,Kaneda Y

更新日期：2004-05-07 00:00:00