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Identification of human semaphorin E gene expression in rheumatoid synovial cells by mRNA differential display.

Abstract：

:Rheumatoid arthritis (RA) is characterised by chronic inflammation of synovial tissue with aggressive proliferation of synovial cells causing destruction of cartilage and bone. Immunopathological mechanisms, infectious causes and genetic factors have been discussed, but the etiology of the disease has not been understood until now. Especially, the mechanisms driving tumourlike growth and invasive behaviour of fibroblastoid synovial cells have not been identified yet. Our aim is to find cellular factors which are mediators for such pathways. One possibility to approach this, is searching for disease-relevant genes. We applied the mRNA-differential display technique to compare mRNA expression patterns of normal and rheumatic synovial fibroblasts. We identified an upregulation of the human semaphorin E gene in rheumatoid synovial fibroblastoid cells. Interestingly semaphorin E is a member of a protein-family described to play an immunosuppressive role via inhibition cytokines. A relevance of this finding towards the pathogenesis of RA is discussed.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Mangasser-Stephan K,Dooley S,Welter C,Mutschler W,Hanselmann RG

doi

10.1006/bbrc.1997.6607

subject

Has Abstract

pub_date

1997-05-08 00:00:00

pages

153-6

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(97)96607-9

journal_volume

234

pub_type

杂志文章

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