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Effects of tributyltin on barrier functions in human intestinal Caco-2 cells.

Abstract：

:The effect of tributyltin (TBT) on human intestinal epithelial cell functions was investigated by using human intestinal Caco-2 cell monolayers. We paid particular attention to the effect of TBT on two barrier functions: the tight junction as a physical barrier and MDR1/P-glycoprotein as a biological barrier. A loss of monolayer integrity was apparent from the TBT treatment and the paracellular permeability was increased by TBT. On the other hand, the activity of P-glycoprotein, which was examined by measuring the accumulation of Rhodamine-123 and daunomycin, was increased by prolonged TBT treatment in a concentration-dependent manner (1-100 nM). Furthermore, it was clarified by Western and Northern blots that this increase was accompanied by the increased expression of MDR1 mRNA and protein. The activation of a multidrug resistance transporter P-glycoprotein by TBT would cause a disorder of the human intestines by changing the drug pharmacokinetics.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Tsukazaki M,Satsu H,Mori A,Sugita-Konishi Y,Shimizu M

doi

10.1016/j.bbrc.2004.01.147

subject

Has Abstract

pub_date

2004-03-19 00:00:00

pages

991-7

issue

4

eissn

0006-291X

issn

1090-2104

pii

S0006291X04002086

journal_volume

315

pub_type

杂志文章

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