Platelet-derived growth factor-BB modulates membrane mobility of beta1 integrins.

abstract：:A Bacillus thuringiensis isolate, 89-T-34-22, belonging to the serovar shandongiensis (H22) produced noninsecticidal and nonhemolytic proteins crystallizing into irregular-shaped parasporal inclusions. The proteins showed in vitro cytotoxicity to human cells, including cancer cells, only when activated by protease tre...

journal_title：Biochemical and biophysical research communications

authors： Lee DW,Akao T,Yamashita S,Katayama H,Maeda M,Saitoh H,Mizuki E,Ohba M

更新日期：2000-05-27 00:00:00

abstract：:Emerging evidence has indicated that transforming growth factor-beta 1 (TGF-β1) induces the epithelial-mesenchymal transition (EMT) in cancer cells, thus promoting their motility and invasiveness. Quercetin, a member of the polyphenolic flavonoid family, has been reported to display anticancer activity against a broad...

journal_title：Biochemical and biophysical research communications

authors： Feng J,Song D,Jiang S,Yang X,Ding T,Zhang H,Luo J,Liao J,Yin Q

更新日期：2018-03-25 00:00:00

abstract：:The chemopreventive effect of nitric oxide-releasing aspirin (NO-ASA) against gastrointestinal tumorigenesis was evaluated in Min (APC(Min/+)) mice. NO-ASA consists of a traditional ASA that bears covalently attached to it an NO-releasing moiety. Four groups (N=10) of six-week-old female C57BL/6J APC(Min/+) and the co...

journal_title：Biochemical and biophysical research communications

authors： Williams JL,Kashfi K,Ouyang N,del Soldato P,Kopelovich L,Rigas B

更新日期：2004-01-16 00:00:00

abstract：:GTP gamma S-dependent phospholipase D (PLD) activity time-dependently increased during differentiation of rat C6 glioma cells to astrocytic phenotypes induced by dibutyryl cyclic AMP (dbcAMP)/theophylline. The changes in PLD mRNA level were examined by reverse transcriptase-polymerase chain reaction (RT-PCR) method us...

journal_title：Biochemical and biophysical research communications

authors： Yoshimura S,Nakashima S,Ohguchi K,Sakai H,Shinoda J,Sakai N,Nozawa Y

更新日期：1996-08-14 00:00:00

abstract：:To study the effect of interleukin-6 (IL-6) on glucose transport, 2-deoxy-D-glucose (2-DOG) uptake in 3T3-L1 adipocytes after incubation with IL-6 was measured. IL-6 increased 2-DOG uptake maximally after 5 hours by 30 +/- 12%, with a half-maximal effect at an IL-6 concentration of approximately 800 U/mL. 3-O-methylgl...

journal_title：Biochemical and biophysical research communications

authors： Stouthard JM,Oude Elferink RP,Sauerwein HP

更新日期：1996-03-18 00:00:00

abstract：:The effect of inositol 1,4,5-trisphosphate (IP3) on Ca2+ release in the transformed murine mast cells, mastocytoma P-815 cells permeabilized with digitonin was studied. Ca2+ was sequestered by intracellular organelles in the presence of ATP until the medium free Ca2+ concentration was lowered to a new steady-state lev...

journal_title：Biochemical and biophysical research communications

authors： Muto Y,Tohmatsu T,Yoshioka S,Nozawa Y

更新日期：1986-02-26 00:00:00

abstract：:In the presence of UDPglucose, rabbit muscle phosphofructokinase appeared to use PPi as a phosphoryl donor, as reported previously (Biochem. Biophys. Res. Commun. 121, 842-847). This apparent activity was due to conversion of UDPglucose and PPi to glucose 1-phosphate and UTP, the latter being metabolized by phosphofru...

journal_title：Biochemical and biophysical research communications

authors： Kruger NJ,Dennis DT

更新日期：1985-01-16 00:00:00

abstract：:Although "secretory" type II 14-kDa phospholipase A2 (sPLA2) activity has been described in neutrophils, direct evidence of enzyme secretion has been elusive. We have used immunogold electron microscopy with polyclonal and monoclonal antibodies to sPLA2 to demonstrate localization of the enzyme to granules of resting ...

journal_title：Biochemical and biophysical research communications

authors： Rosenthal MD,Gordon MN,Buescher ES,Slusser JH,Harris LK,Franson RC

更新日期：1995-03-17 00:00:00

abstract：:Seed germination is a crucial stage for plant development and agricultural production. To investigate its complex regulation process, the RNA-Seq study of rice embryo was conducted at three time points of 0, 12 and 48 h post imbibition (HPI). Dynamic transcriptional alterations were observed, especially in the early s...

journal_title：Biochemical and biophysical research communications

authors： Wei T,He Z,Tan X,Liu X,Yuan X,Luo Y,Hu S

更新日期：2015-08-14 00:00:00

abstract：:Saccharomyces cerevisiae antizyme (AZ) resembles mammalian AZ in its mode of synthesis by translational frameshifting and its ability to inhibit and facilitate the degradation of ornithine decarboxylase (ODC). Despite many studies on the interaction of AZ and ODC, the ODC:AZ complex has not been purified from any sour...

journal_title：Biochemical and biophysical research communications

authors： Chattopadhyay MK,Fernandez C,Sharma D,McPhie P,Masison DC

更新日期：2011-03-11 00:00:00

abstract：:Relative orientation of recombination substrates, neo gene, strongly influenced homologous recombination events in a bovine papillomavirus shuttle vector. Between direct repeats, recombination occurred at a high frequency while between inverted repeats, it was rare. Double strand break near the mutation site increased...

journal_title：Biochemical and biophysical research communications

authors： Naito A,Kitamura Y,Yoshikura H

更新日期：1991-01-15 00:00:00

abstract：:The Na(+)/K(+) ATPase generates the Na(+) and K(+) concentration gradients across the plasma membrane and is thus essential for cellular electrolyte homeostasis, cell membrane potential and cell volume maintenance. A powerful regulator of Na(+)/K(+) ATPase is the serum- and glucocorticoid-inducible kinase 1 (SGK1). Th...

journal_title：Biochemical and biophysical research communications

authors： Hosseinzadeh Z,Schmid E,Shumilina E,Laufer S,Borst O,Gawaz M,Lang F

更新日期：2014-09-26 00:00:00

abstract：:Histone deacetylase inhibitors (HDACIs) are promising anti-tumor agents that selectively induce cell cycle arrest, differentiation and/or apoptosis of tumor cells. Fundamentally, HDACIs are proposed to function by activating the transcription of genes, including the potent cyclin dependent kinase inhibitor p21(WAF1). ...

journal_title：Biochemical and biophysical research communications

authors： Hirsch CL,Ellis DJ,Bonham K

更新日期：2010-11-26 00:00:00

abstract：:Pain is a common symptom of injuries and inflammatory-related conditions. The perception of pain, commonly known as nociception, depends on integrated receptors and molecular pathways. Inflammatory mediators are involved in the genesis, persistence, and severity of pain. Noxious stimuli can trigger a cascade of inflam...

journal_title：Biochemical and biophysical research communications

authors： Haddad JJ

更新日期：2007-02-09 00:00:00

abstract：:Disturbance of endoplasmic reticulum (ER) homeostasis causes ER stress (ERS), and triggers the unfolded protein response (UPR) that consequently reduces accumulation of unfolded proteins by increasing the quantity of ER chaperones. Calumenin, a Ca(2+)-binding protein with multiple EF hand motifs, which is located in t...

journal_title：Biochemical and biophysical research communications

authors： Lee JH,Kwon EJ,Kim DH

更新日期：2013-09-27 00:00:00

abstract：:The VLDL (very low-density lipoprotein) receptor is a peripheral lipoprotein receptor expressing in fatty acid active tissues abundantly. In the Balb/c fasting mice, VLDL receptor as well as LPL (lipoprotein lipase), FAT (fatty acid translocase)/CD36, H-FABP (heart-type fatty acid-binding protein), ACS (acyl-CoA synth...

journal_title：Biochemical and biophysical research communications

authors： Kamataki A,Takahashi S,Masamura K,Iwasaki T,Hattori H,Naiki H,Yamada K,Suzuki J,Miyamori I,Sakai J,Fujino T,Yamamoto TT

更新日期：2002-05-10 00:00:00

abstract：:Cell extracts from wheat embryos have been widely used for mRNA-directed protein production. Here, we found that a significant fraction of exogenous linear RNAs are circularized in a wheat embryo extract. The circularization was seen only in uncapped RNAs. The amount of the circular species reached around 1% of the in...

journal_title：Biochemical and biophysical research communications

authors： Makino S,Sawasaki T,Tozawa Y,Endo Y,Takai K

更新日期：2006-09-08 00:00:00

abstract：:YKL-40 (cartilage gp-39), is a mammalian glycoprotein related in sequence to chitinases. Its function is unknown, but it is thought to be involved in tissue remodeling. Immunocytochemical staining of YKL-40 in guinea pig chondrocytes (GPC), rabbit chondrocytes (RC), and rabbit synoviocytes (RS) was higher in dividing ...

journal_title：Biochemical and biophysical research communications

authors： De Ceuninck F,Gaufillier S,Bonnaud A,Sabatini M,Lesur C,Pastoureau P

更新日期：2001-07-27 00:00:00

abstract：:HMG-CoA reductase was located to the envelope membranes of pea etioplasts, the first report of the suborganelle localization of this key enzyme in isoprenoid synthesis. The enzyme was purified 156 fold from isolated envelope membranes. Purification was achieved by detergent solubilization, hydroxylapatite chromatograp...

journal_title：Biochemical and biophysical research communications

authors： Wilson TM,Russell DW

更新日期：1992-04-15 00:00:00

abstract：:Rab proteins, members of the Ras superfamily of small GTPases, play regulatory roles in intercompartmental vesicular transport. Each step of traffic seems to require the participation of at least one distinct Rab, with the Rab3 subfamily involved in stimulated exocytosis. We report our studies on the murine rab3D gene...

journal_title：Biochemical and biophysical research communications

authors： Adachi R,Nigam R,Tuvim MJ,DeMayo F,Dickey BF

更新日期：2000-07-14 00:00:00

abstract：:In growing neurite of neuronal cells, it is suggested that α/β-tubulin heterodimers assemble to form microtubule, and assembly of microtubule promotes neurite elongation. On the other hand, recent studies reveal importance of intracellular Cl(-) in regulation of various cellular functions such as cell cycle progressio...

journal_title：Biochemical and biophysical research communications

authors： Nakajima K,Niisato N,Marunaka Y

更新日期：2012-08-24 00:00:00

abstract：:DNA containing unmethylated cytosine-guanine motifs (CpG DNA) initiates innate immune responses, including the secretion of cytokines from macrophages. Some antimicrobial peptides modulate the responses to CpG DNA, although the molecular mechanisms of this process remain unclear. This study examined the effects of fou...

journal_title：Biochemical and biophysical research communications

authors： Nishihara S,Kawasaki K

更新日期：2020-09-10 00:00:00

abstract：:Using fluorescein isothiocyanate (FITC)-conjugated H-2K(b) CTL epitope (SIINFEKL) as a model system, we investigated the antigen delivery route by pH-sensitive liposomes in vivo. Fluorescence was initially detected in lymph nodes at 3 h after immunization, and its intensity reached a peak value in superticial inguinal...

journal_title：Biochemical and biophysical research communications

authors： Lee KY,Chun E,Seong BL

更新日期：2002-04-05 00:00:00

abstract：:Signal regulatory protein α (SIRPα) is a transmembrane protein that binds the protein tyrosine phosphatases SHP-1 and SHP-2 through its cytoplasmic region and is abundantly expressed on dendritic cells and macrophages. Wild-type (WT) C57BL/6 mice are known to be resistant to Leishmania major infection. We here found t...

journal_title：Biochemical and biophysical research communications

authors： Morimoto N,Murata Y,Motegi S,Suzue K,Saito Y,Okazawa H,Ohnishi H,Kotani T,Kusakari S,Ishikawa O,Matozaki T

更新日期：2010-10-22 00:00:00

abstract：:Oxidative stress plays a key role in the pathogenesis of diabetic nephropathy (DN). The anti-aging protein Klotho has been demonstrated to have antioxidant capacity. Nuclear factor-erythroid 2-related factor 2 (Nrf2) is a central transcription factor regulating antioxidant responses. The present study aimed to explore...

journal_title：Biochemical and biophysical research communications

authors： Xing L,Guo H,Meng S,Zhu B,Fang J,Huang J,Chen J,Wang Y,Wang L,Yao X,Wang H

更新日期：2021-01-01 00:00:00

abstract：:High sensitivity detection of DNA is essential for genomics. The intrinsic fluorescence from DNA is very weak and almost all methods for detecting DNA rely on the use of extrinsic fluorescent probes. We show that the intrinsic emission from DNA can be enhanced many-fold by spatial proximity to silver island films. Sil...

journal_title：Biochemical and biophysical research communications

authors： Lakowicz JR,Shen B,Gryczynski Z,D'Auria S,Gryczynski I

更新日期：2001-09-07 00:00:00

abstract：:Here we analyzed Pfkfb3 and Pfkfb4 gene expression in rat testis development, isolated testicular cells and spermatozoa. Real time RT-PCR analysis during testis development showed the maximum expression of Pfkfb3 in pre-puber samples and of Pfkfb4 in adult samples. Western blot analysis showed that uPFK-2 protein, a p...

journal_title：Biochemical and biophysical research communications

authors： Gómez M,Navarro-Sabaté A,Manzano A,Duran J,Obach M,Bartrons R

更新日期：2009-09-18 00:00:00

abstract：:We located a novel binding site for grayanotoxin on the cytoplasmic linkers of voltage-dependent cardiac (rH1) or skeletal-muscle (mu 1) Na(+) channel isoforms (segments S4-S5 in domains D1 and D4), using the alanine scanning substitution method. GTX-modification of Na(+) channels, transiently expressed in HEK 293 cel...

journal_title：Biochemical and biophysical research communications

authors： Maejima H,Kinoshita E,Yuki T,Yakehiro M,Seyama I,Yamaoka K

更新日期：2002-07-12 00:00:00

abstract：:L86-8275 [(-) cis-5,7-dihydroxy-2-(2-chlorophenyl)-8[4-(3-hydroxy-1- methyl)-piperidinyl]-4H-benzopyran-4-one] directly inhibits immunoprecipitated Cdc2 kinase activity from G2/M synchronized MDA-MB-468 breast carcinoma cells and is at least 250-fold more potent than either quercetin or genistein. Purified sea-star Cd...

journal_title：Biochemical and biophysical research communications

authors： Losiewicz MD,Carlson BA,Kaur G,Sausville EA,Worland PJ

更新日期：1994-06-15 00:00:00

abstract：:It is unknown how very short introns (<65 nt; termed 'ultra-short' introns) could be spliced in a massive spliceosome (>2.7 MDa) without steric hindrance. By screening an annotated human transcriptome database (H-InvDB), we identified three model ultra-short introns: the 56-nt intron in the HNRNPH1 (hnRNP H1) gene, th...

journal_title：Biochemical and biophysical research communications

authors： Sasaki-Haraguchi N,Shimada MK,Taniguchi I,Ohno M,Mayeda A

更新日期：2012-06-29 00:00:00