Bovine liver cDNA clones encoding a precursor of the alpha-subunit of the mitochondrial ATP synthase complex.

Abstract:

:cDNA clones encoding a precursor of the alpha-subunit of the mitochondrial ATP synthase complex have been isolated from a bovine liver cDNA library using the alpha-subunit gene from Saccharomyces cerevisiae as a probe. Analyses of the nucleotide sequence of these cDNA clones reveal that the bovine liver ATP synthase alpha-subunit is initially synthesized as a precursor with an aminoterminal extension 43 amino acids in length. This aminoterminal presequence contains seven basic residues, no acidic residues, and seven polar uncharged serine and threonine residues. A single mRNA species, approximately 1.85 kb in length, was detected for the ATP synthase alpha-subunit precursor in both bovine liver and heart.

authors

Breen GA

doi

10.1016/s0006-291x(88)80709-5

subject

Has Abstract

pub_date

1988-04-15 00:00:00

pages

264-9

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(88)80709-5

journal_volume

152

pub_type

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