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Chlorpromazine inhibits human natural killer cell activity and antibody-dependent cell-mediated cytotoxicity.

Abstract：

:The phenothiazine antipsychotic drug chlorpromazine, a potent calmodulin antagonist, inhibited human natural killer cell-mediated cytotoxicity in a dose-dependent manner. This inhibition of natural killer cell activity was not due to interference with conjugate formation, nor was it due to toxicity to the natural killer cells or nonspecific alteration of the target cells. Chlorpromazine also suppressed antibody-dependent cell-mediated cytotoxicity in a dose-dependent fashion, suggesting that the two activities share a calmodulin-dependent step. Finally, it was not possible to overcome chlorpromazine-mediated inhibition of natural killer cell activity by first treating the cells with interleukin-2 or Beta-interferon.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Steele TA,Brahmi Z

doi

10.1016/s0006-291x(88)80536-9

subject

Has Abstract

pub_date

1988-09-15 00:00:00

pages

597-602

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(88)80536-9

journal_volume

155

pub_type

杂志文章

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