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Evidence for lateral mobility of voltage sensors in prokaryotic voltage-gated sodium channels.

Abstract：

:Voltage-sensor domains (VSDs) in voltage-gated ion channels are thought to regulate the probability that a channel adopts an open conformation by moving vertically in the lipid bilayer. Here we characterized the movement of the VSDs of the prokaryotic voltage-gated sodium channel, NaChBac. Substitution of residue T110, which is located on the extracellular side of the fourth transmembrane helix of the VSD, by cysteine resulted in the formation of a disulfide bond between adjacent subunits in the channel. Our results suggest that T110 residues in VSDs of adjacent subunits can come into close proximity, implying that the VSDs can move laterally in the membrane and constitute a mechanism that regulates channel activity.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Nagura H,Irie K,Imai T,Shimomura T,Hige T,Fujiyoshi Y

doi

10.1016/j.bbrc.2010.07.070

subject

Has Abstract

pub_date

2010-08-27 00:00:00

pages

341-6

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(10)01381-1

journal_volume

399

pub_type

杂志文章

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