The structure of the human LIM protein ACT gene and its expression in tumor cell lines.

abstract：:In hematopoietic cells, Ras has been implicated in signaling pathways that prevent apoptosis triggered by deprivation of cytokines, such as interleukin-3 (IL-3). However, the mechanism whereby Ras suppresses cell death remains incompletely understood. We have investigated the role of Ras in IL-3 signal transduction by...

journal_title：Biochemical and biophysical research communications

authors： Terada K,Kaziro Y,Satoh T

更新日期：2000-01-07 00:00:00

abstract：:The mouse nuclear receptor ERRgamma (estrogen receptor-related receptor gamma) is highly expressed in heart, skeletal muscle, kidney, and brain, as well as in the developing nervous system. We found that the expression of the coactivators PGC-1 (PGC-1alpha) and PERC (PGC-1beta) in mammalian cells augmented potently th...

journal_title：Biochemical and biophysical research communications

authors： Hentschke M,Süsens U,Borgmeyer U

更新日期：2002-12-20 00:00:00

abstract：:Conventional ESR spectra of 16-doxyl-stearic acid bound to bovine and human serum albumin were recorded at different temperatures in order to investigate the status of spin-labeled fatty acid in the interior of the protein globule. A computer spectrum simulation of measured spectra, performed by non-linear least-squar...

journal_title：Biochemical and biophysical research communications

authors： Gurachevsky A,Shimanovitch E,Gurachevskaya T,Muravsky V

更新日期：2007-09-07 00:00:00

abstract：:KK mice are genetically diabetic animals, showing glucose intolerance and insulin resistance. We examined the effects of 3,3',5-triiodo-L-thyronine (T3) on the blood glucose level and on mRNA levels of muscle cell differentiation markers in hyperglycemic KK mice. T3 treatment (T1, 1 mg; T3, 3 mg; T10, 10 mg/kg/day) of...

journal_title：Biochemical and biophysical research communications

authors： Shimokawa T,Kato M,Shioduka K,Irie J,Ezaki O

更新日期：1997-06-27 00:00:00

abstract：:In this study, we investigated the IL-1 beta converting enzyme (ICE) family cysteine proteases responsible for the Fas-mediated apoptosis of rheumatoid arthritis (RA) synoviocytes and their involvement in proinflammatory cytokine production. CPP32 inhibitor, but not ICE inhibitor, was capable of inhibiting the Fas-med...

journal_title：Biochemical and biophysical research communications

authors： Sekine C,Yagita H,Kobata T,Hasunuma T,Nishioka K,Okumura K

更新日期：1996-11-01 00:00:00

abstract：:Human thyroperoxidase (TPO) ectodomain is successively made of myeloperoxidase-, complement control protein repeat-, and epidermal growth factor-like gene modules. However, the TPO immunodominant region targeted by autoantibodies from patients with an autoimmune thyroid disease has not been mapped on the molecule. Her...

journal_title：Biochemical and biophysical research communications

authors： Blanchin S,Estienne V,Guo J,Rapoport B,McLachlan SM,Carayon P,Ruf J

更新日期：2002-08-02 00:00:00

abstract：:When human ovarian carcinoma cells are challenged with endotoxin, an I kappa B kinase is transiently induced within 3 to 5 min. This enzyme activity causes the hyperphosphorylation and subsequent degradation of I kappa B which allows NF-kappa B to translocate to the nucleus where it activates transcription. When endot...

journal_title：Biochemical and biophysical research communications

authors： Kohler NG,Joly A

更新日期：1997-03-27 00:00:00

abstract：:In order to establish a working cellular model for the study of post-receptor signaling events, insulin-dependent phosphatidylinositol 3' (PtdIns 3')-kinase activity was investigated in circulating mononuclear cells from normal subjects. The p85 alpha regulatory subunit of PtdIns 3'-kinase co-precipitated with activat...

journal_title：Biochemical and biophysical research communications

authors： Renard E,Grigorescu F,Lavabre C,Kahn CR

更新日期：1995-04-06 00:00:00

abstract：:Inhibition of the infectivity and cytopathic effect of human immunodeficiency virus type 1 (HIV-1) by the immunoactive fractions obtained from LEM, which is an extract of the culture medium of Lentinus edodes mycelia, is reported. A purified fraction, EPS4, obtained from LEM by ethanol precipitation followed by hydrop...

journal_title：Biochemical and biophysical research communications

authors： Suzuki H,Okubo A,Yamazaki S,Suzuki K,Mitsuya H,Toda S

更新日期：1989-04-14 00:00:00

abstract：:H-rev107, which belongs to class II tumor suppressor genes, is ubiquitously expressed in normal cells, but is downregulated in many carcinomas and tumor cell lines. Sequence analysis showed that the murine H-rev107 gene is composed of five exons and four introns. Transfections revealed that 7.6 kb of the H-rev107 prom...

journal_title：Biochemical and biophysical research communications

authors： Roder K,Latasa MJ,Sul HS

更新日期：2002-05-03 00:00:00

abstract：:Ceramide kinase (CERK) and its product, ceramide-1-phosphate (Cer-1-P), are implicated in signaling processes, but the action mechanisms are not fully elucidated. When checking for intracellular effects of Cer-1-P by exposing CERK-expressing CHO cells to truncated ceramides, an unexpected decrease in CERK activity and...

journal_title：Biochemical and biophysical research communications

authors： Van Overloop H,Van Veldhoven PP

更新日期：2007-12-07 00:00:00

abstract：:Histamine stimulation of cultured human umbilical vein endothelial cells induced dose- and time-dependent increases in glycerophosphoinositol (GroPIns), inositol-1-phosphate (InsP), inositolbisphosphate (InsP2) and inositoltrisphosphate (InsP3) in addition to release of thromboxane A2 and prostacyclin. Increases in In...

journal_title：Biochemical and biophysical research communications

authors： Resink TJ,Grigorian GYu,Moldabaeva AK,Danilov SM,Bühler FR

更新日期：1987-04-14 00:00:00

abstract：:Bovine pulmonary artery endothelial cells (BPAEC) were prelabeled with [3H]choline or [3H]myristic acid to selectively label endogenous phosphatidylcholine. BPAEC were stimulated with ATP and bradykinin (BK), and phospholipase D (PLD) activation was detected as a 4-fold increase in [3H]choline in cells prelabeled with...

journal_title：Biochemical and biophysical research communications

authors： Martin TW,Feldman DR,Goldstein KE,Wagner JR

更新日期：1989-11-30 00:00:00

abstract：:Epididymal fluid from rats rendered infertile by oral administration of ornidazole contains a protein CAP1 (contraception-associated protein 1) that is absent from epididymal fluid, but present on epididymal sperm, from fertile vehicle-treated rats. The gene for CAP1 has been isolated from a rat testis cDNA library an...

journal_title：Biochemical and biophysical research communications

authors： Wagenfeld A,Gromoll J,Cooper TG

更新日期：1998-10-20 00:00:00

abstract：:Rat intoxication with a single dose of the hepatotoxin carbon tetrachloride induces a significant modification of liver protein kinase C total activity which depends on the degree of the intrahepatocyte oxidative unbalance provoked by various concentrations of the haloalkane. Low carbon tetrachloride amounts stimulate...

journal_title：Biochemical and biophysical research communications

authors： Pronzato MA,Domenicotti C,Rosso E,Bellocchio A,Patrone M,Marinari UM,Melloni E,Poli G

更新日期：1993-07-30 00:00:00

abstract：:Aminopeptidase B (Ap-B) is a Zn2+-aminopeptidase of the M1 family which is implicated, in conjunction with the nardilysin endoprotease, in the generation of miniglucagon, a peptide involved in the maintenance of glucose homeostasis. Other in vivo physiological roles have been established for this vertebrate enzyme, su...

journal_title：Biochemical and biophysical research communications

authors： Cadel S,Darmon C,Désert A,Mahbouli M,Piesse C,Ghélis T,Lafont R,Foulon T

更新日期：2019-05-14 00:00:00

abstract：:5-Lipoxygenase (5LO) catalyzes two steps in the biosynthesis of leukotrienes (LTs), lipid mediators of inflammation derived from arachidonic acid. LTs function in normal host defense, and have pathophysiological roles in chronic inflammatory diseases as asthma and atherosclerosis. Also, possible effects of 5LO product...

journal_title：Biochemical and biophysical research communications

authors： Rådmark O,Samuelsson B

更新日期：2010-05-21 00:00:00

abstract：UNLABELLED:The L-arginine-nitric oxide (NO) pathway was investigated in human internal mammary artery (HIMA) in vitro. HIMA rings were mounted in organ bath, and then incubated in Krebs buffer for 1 to 8 hrs, relaxing agents were tested. Under these conditions, L-arginine (0.1 microM - 1 mM) elicited only minor relaxat...

journal_title：Biochemical and biophysical research communications

authors： Qi X,Chen D,Nottin R,Mace L,Herve P,Weiss M

更新日期：1993-08-31 00:00:00

abstract：:Mutations in the gene coding for connexin26 (Cx26) is the most common cause of human nonsyndromic hereditary deafness. To investigate deafness mechanisms underlying Cx26 null mutations, we generated three independent lines of conditional Cx26 null mice. Cell differentiation and gross cochlear morphology at birth seeme...

journal_title：Biochemical and biophysical research communications

authors： Wang Y,Chang Q,Tang W,Sun Y,Zhou B,Li H,Lin X

更新日期：2009-07-17 00:00:00

abstract：:Recently, we reported that in various cell lines under conditions of deenergization of the mitochondrial membrane, the release of Ca(2+) from the endoplasmic reticulum (ER) does not produce the expected activation of store-operated calcium channels (SOCs) in the plasma membrane. In the present work, we examined the ac...

journal_title：Biochemical and biophysical research communications

authors： Wasniewska M,Karczmarewicz E,Pronicki M,Piekutowska-Abramczuk D,Zablocki K,Popowska E,Pronicka E,Duszyński J

更新日期：2001-05-11 00:00:00

abstract：:Although it's well known that protein carbonyl (PCO) and advanced glycation end-products (AGEs) levels are elevated in plasma from patients with renal dysfunction, we recently identified patients who had no renal dysfunction but possessed high levels of plasma pentosidine (PEN), which is an AGEs, and low vitamin B6 le...

journal_title：Biochemical and biophysical research communications

authors： Koike S,Kayama T,Arai M,Horiuchi Y,Kobori A,Miyashita M,Itokawa M,Ogasawara Y

更新日期：2015-11-13 00:00:00

abstract：:C57BL/6 mice were orally infected with different doses of cysts of ME49 strain of Toxoplasma gondii to produce groups of acutely and chronically infected mice. Sera were obtained at different periods post-infection. SDS-PAGE was ran with excretory/secretory antigens of ME49 and RH strains of T. gondii, followed by Wes...

journal_title：Biochemical and biophysical research communications

authors： Rahmah N,Anuar AK

更新日期：1992-08-31 00:00:00

abstract：:The nuclear receptors for heme, REV-ERBα and REV-ERBβ, play important roles in the regulation of metabolism and inflammation. Recently it was demonstrated that reduced REV-ERBα expression in hematopoetic cells in LDL receptor null mice led to increased atherosclerosis. We sought to determine if synthetic REV-ERB agoni...

journal_title：Biochemical and biophysical research communications

authors： Sitaula S,Billon C,Kamenecka TM,Solt LA,Burris TP

更新日期：2015-05-08 00:00:00

abstract：:T-type Ca(2+) channels are important regulators of peripheral sensory neuron excitability. Accordingly, T-type Ca(2+) currents are often increased in various pathological pain conditions, such as inflammation or nerve injury. Here we investigated effects of inflammation on functional expression of T-type Ca(2+) channe...

journal_title：Biochemical and biophysical research communications

authors： Huang D,Liang C,Zhang F,Men H,Du X,Gamper N,Zhang H

更新日期：2016-04-29 00:00:00

abstract：:Activated neutrophils generate the potent oxidant hypochlorous acid (HOCl) from the enzyme myeloperoxidase (MPO). A proposed bio-marker for MPO-derived HOCl in vivo is 3-chlorotyrosine, elevated levels of which have been measured in several human inflammatory pathologies. However, it is unlikely that HOCl is produced ...

journal_title：Biochemical and biophysical research communications

authors： Whiteman M,Spencer JP

更新日期：2008-06-20 00:00:00

abstract：:A total of 951 backcross progeny have been obtained from a backcross segregating for the mouse deafness mutation, shaker-2(sh-2). Linkage analysis provides a detailed genetic map in the vicinity of sh-2 which comprises 40 backcross mice identified as recombinant within a 4 cM region. This allows construction of a cont...

journal_title：Biochemical and biophysical research communications

authors： Wakabayashi Y,Kikkawa Y,Matsumoto Y,Shinbo T,Kosugi S,Chou D,Furuya M,Jishage K,Noda T,Yonekawa H,Kominami R

更新日期：1997-05-08 00:00:00

abstract：:Sugars will eventually be exported transporters (SWEETs) are a group of recently identified sugar transporters in plants that play important roles in diverse physiological processes. However, currently, limited information about this gene family is available in pineapple (Ananas comosus). The availability of the recen...

journal_title：Biochemical and biophysical research communications

authors： Guo C,Li H,Xia X,Liu X,Yang L

更新日期：2018-02-05 00:00:00

abstract：:Vascular endothelial growth factor (VEGF), also known as vascular permeability factor, is highly expressed in the myocardium under various stimuli including hypoxia and ischemia. On the other hand, lipopolysaccharide (LPS) causes systemic inflammatory response syndrome (SIRS), which consists of systemic pathophysiolog...

journal_title：Biochemical and biophysical research communications

authors： Sugishita Y,Shimizu T,Yao A,Kinugawa Ki,Nojiri T,Harada K,Matsui H,Nagai R,Takahashi T

更新日期：2000-02-16 00:00:00

abstract：:RNA-binding proteins are believed to play important roles in regulation of neural functions. Recently, a mouse cDNA encoding the cold-inducible RNA-binding protein, Cirp, has been isolated, the amino acid sequence of which showed similarity to plant circadian rhythm proteins. In the present study, diurnal expression o...

journal_title：Biochemical and biophysical research communications

authors： Nishiyama H,Xue JH,Sato T,Fukuyama H,Mizuno N,Houtani T,Sugimoto T,Fujita J

更新日期：1998-04-17 00:00:00

abstract：:A key feature of O2 sensing by chemoreceptor tissues is the hypoxic inhibition of K+ channels. However, mechanisms coupling a fall of pO2 to channel closure differ between tissues: O2 regulation of K+ channels in chemoreceptive neuroepithelial bodies and their immortal counterparts, H146 cells, involves altered reacti...

journal_title：Biochemical and biophysical research communications

authors： O'Kelly I,Peers C,Kemp PJ

更新日期：2001-05-25 00:00:00