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Stress-induced p53 runs a transcription-independent death program.

Abstract：

:The transcription-independent p53-mediated apoptotic response has obtained a solid mechanistic basis in recent years. A fraction of stress-induced wild type p53 protein rapidly translocates to mitochondria in response to genotoxic, hypoxic, and oxidative stresses in established cell lines and primary cells, as well as in physiological and pathophysiologic stress responses in the animal. While the groundwork of mechanisms and kinetics of direct mitochondrial p53 activities is laid out, the quantitative contribution of this pathway to total p53-mediated apoptosis and tumor suppression in vivo remains to be elucidated. An update on these efforts is given here.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Erster S,Moll UM

doi

10.1016/j.bbrc.2005.03.187

subject

Has Abstract

pub_date

2005-06-10 00:00:00

pages

843-50

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(05)00710-2

journal_volume

331

pub_type

杂志文章,评审

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