Stress-activated protein kinase-dependent induction of c-fos by Cd(2+) is mediated by MKK7.

abstract：:ATP is the universal energy currency but mysteriously its cellular concentration is much higher than that needed for providing energy. Recently ATP was decoded to act as a hydrotrope to dissolve liquid-liquid phase separation (LLPS) of FUS whose aggregation leads to ALS/FTD. By DIC microscopy and NMR, here we characte...

journal_title：Biochemical and biophysical research communications

authors： Kang J,Lim L,Song J

更新日期：2018-10-02 00:00:00

abstract：:Serum prealbumin isolated from a Japanese patient with familial amyloidotic polyneuropathy (FAP) has been found to consist of a mixture of normal prealbumin and a prealbumin variant which contains a methionine for valine substitution at position 30. The prealbumin variant in the serum is identical to the prealbumin va...

journal_title：Biochemical and biophysical research communications

authors： Nakazato M,Kangawa K,Minamino N,Tawara S,Matsuo H,Araki S

更新日期：1984-07-31 00:00:00

abstract：:Oleoyl coenzyme A and other acyl-CoA derivatives inhibited ADP or thrombin-induced aggregation of platelets. Arachidonic acid-induced aggregation was also inhibited, but not the slower aggregation caused by 1-oleoyl-2-acetylglycerol or tetradecanoyl-phorbol-13-acetate. Coenzyme A and free fatty acids had little or no ...

journal_title：Biochemical and biophysical research communications

authors： Lascu I,Edwards B,Cucuianu MP,Deamer DW

更新日期：1988-10-31 00:00:00

abstract：:BMP-3b (also called GDF-10) is a novel BMP-3-related protein recently discovered in rat femur tissue. Gene expression of BMP-3b in osteoblastic cells and its regulation by prolonged culture, BMP-2 and transforming growth factor beta1 (TGF-beta1) were examined. The BMP-3b gene was highly expressed in rat osteoblasts ob...

journal_title：Biochemical and biophysical research communications

authors： Hino J,Matsuo H,Kangawa K

更新日期：1999-03-16 00:00:00

abstract：:The force-extension behaviour of synthesized double-stranded DNAs (dsDNAs) designed to have 2.1% or 6.6% of the thymine bases alkyne functionalized was studied using near infrared (NIR) optical tweezers. Measurements were carried out on substrates with and without flurophores covalently attached to the alkyne moiety o...

journal_title：Biochemical and biophysical research communications

authors： Raudsepp A,Kent LM,Hall SB,Williams MAK

更新日期：2018-02-12 00:00:00

abstract：:The CXC chemokines keratinocyte-derived chemokine (KC, CXCL1) and macrophage inflammatory protein-2 (MIP-2, CXCL2) activate G-protein coupled receptor CXCR2 and are believed to have similar inflammatory effects in mice. Their specific signaling mechanisms remain elusive. A wide variety of cellular events, mediators an...

journal_title：Biochemical and biophysical research communications

authors： Lei X,Hossain M,Qadri SM,Liu L

更新日期：2012-07-06 00:00:00

abstract：:Glucose tolerance progressively declines with age in humans and is often accompanied by insulin resistance and a high prevalence of type 2 diabetes. Little is known about the mechanism underlying the age-related changes in glucose metabolism. Here we reported that acid-sensing ion channel 3 (ASIC3) is functionally exp...

journal_title：Biochemical and biophysical research communications

authors： Huang SJ,Yang WS,Lin YW,Wang HC,Chen CC

更新日期：2008-07-11 00:00:00

abstract：:Phosphate in manure of monogastric animals pollutes the environment if improperly applied to soil. Strategies that reduce phosphate inputs into animal production systems reduce environmental pollution. Using a novel vaccine to fibroblast growth factor-23 (FGF-23), we induced neutralizing antibodies that reduced the ph...

journal_title：Biochemical and biophysical research communications

authors： Bobeck EA,Burgess KS,Jarmes TR,Piccione ML,Cook ME

更新日期：2012-04-13 00:00:00

abstract：:CRTH2, the second receptor for prostaglandin D(2) (PGD(2)), is thought to play a role in allergic inflammations through the induction of chemotactic migration and/or the activation of Th2, eosinophils, and basophils, in humans. We previously identified the mouse CRTH2 homolog of human CRTH2 and suggest that animal mod...

journal_title：Biochemical and biophysical research communications

authors： Hirai H,Abe H,Tanaka K,Takatsu K,Sugamura K,Nakamura M,Nagata K

更新日期：2003-08-08 00:00:00

abstract：:The circular RNA (circRNA) circEPSTI1 has been recently identified as a new cancer-associated circRNA in multiple types of cancer. However, the involvement of circEPSTI1 in non-small cell lung cancer (NSCLC) remains unexplored. The purpose of this study was to explore the expression pattern and function of circEPSTI1 ...

journal_title：Biochemical and biophysical research communications

authors： Yang T,Li M,Li H,Shi P,Liu J,Chen M

更新日期：2020-09-10 00:00:00

abstract：:IL-6 is a growth and survival factor for myeloma cells, although the mechanism by which it induces myeloma cell proliferation through gene expression is largely unknown. Microarray analysis showed that some B-cell lymphoma-associated oncogenes such as Bcl6, which is absent in normal plasma cells, were upregulated by I...

journal_title：Biochemical and biophysical research communications

authors： Tsuyama N,Danjoh I,Otsuyama K,Obata M,Tahara H,Ohta T,Ishikawa H

更新日期：2005-11-11 00:00:00

abstract：BACKGROUND:Conventional hepatitis B virus (HBV) vaccines fail to induce protective antibody titers in 5-10% of immune-competent vaccines. Therefore, safe and effective HBV vaccines are still clinically needed. METHODS:In this study, we developed a plasmid DNA vaccine encoding CD317 single-chain fragment variable (α317...

journal_title：Biochemical and biophysical research communications

authors： Zhang G,Li X,Liu L,Li J,Chen Q,Huang S,Li Y,Wan X

更新日期：2018-10-12 00:00:00

abstract：:G-quadruplex is one of the best-studied non-B type DNA that is now known to be prevalently present in the genomes of almost all the biological species. Recent studies reveal roles of G-quadruplex (G4) structures in various nucleic acids and chromosome transactions. In this short article, we will first describe recent ...

journal_title：Biochemical and biophysical research communications

authors： Masai H,Tanaka T

更新日期：2020-10-08 00:00:00

abstract：:Baculovirus p35 belongs to the early class of genes of AcMNPV and requires viral factors like Immediate Early protein-1 for its transcription. To investigate the role of host factors in regulating p35 gene expression, the putative transcription factor binding sites were examined in silico and the role of these factors...

journal_title：Biochemical and biophysical research communications

authors： Mohareer K,Sahdev S,Hasnain SE

更新日期：2011-11-04 00:00:00

abstract：:The polycystic kidney disease (PKD) 1L3-PKD2L1 channel is a candidate sour taste receptor expressed in mammalian taste receptor cells. Various acids are reported to activate PKD channels after the removal of the acid stimuli, but little information is available on the activation of these channels by acetic acid. It wa...

journal_title：Biochemical and biophysical research communications

authors： Ishii S,Misaka T,Kishi M,Kaga T,Ishimaru Y,Abe K

更新日期：2009-07-31 00:00:00

abstract：:In this study, an endogenous factor(s) involved in the suppression of the induction of CYP1A1 was studied. Analyzing the sequences, we found that the sequence of xenobiotic responsive element (XRE) in the upstream region of the human CYP1A1 gene was overlapped with that of the upstream stimulatory factor 1 (USF1)-bind...

journal_title：Biochemical and biophysical research communications

authors： Takahashi Y,Nakayama K,Itoh S,Kamataki T

更新日期：1997-11-17 00:00:00

abstract：:Cardiomyogenesis is influenced by factors secreted by anterior-lateral and extra-embryonic endoderm. Differentiation of embryonic stem cells in embryoid bodies allows to study the influence of growth factors on cardiomyogenesis. By these means SPARC was identified as a new factor enhancing cardiomyogenesis [M. Stary, ...

journal_title：Biochemical and biophysical research communications

authors： Stary M,Schneider M,Sheikh SP,Weitzer G

更新日期：2006-05-05 00:00:00

abstract：:Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a type II transmembrane cytokine and a potent inducer of apoptosis. Epidermal growth factor (EGF) signaling is well known to involve in tumor survival and overexpression of EGF receptor (EGF-R) attributes to decreased responsiveness to many avail...

journal_title：Biochemical and biophysical research communications

authors： Park SY,Seol DW

更新日期：2002-07-12 00:00:00

abstract：:A cDNA for murine transcription factor S-II (Hirashima et al., J. Biol. Chem (1988) 263, 3858-3863) was inserted into a silkworm baculovirus vector and expressed in Bm-N cells, a cell line of Bombyx mori maintained in the laboratory. Recombinant S-II was purified from virus-infected cell extracts to near homogeneity b...

journal_title：Biochemical and biophysical research communications

authors： Hirashima S,Horikoshi N,Sekimizu K,Natori S

更新日期：1989-05-15 00:00:00

abstract：:Gut microbiota is critical for maintaining body immune homeostasis and thus affects tumor growth and therapeutic efficiency. Here, we investigated the link between microbiota and tumorgenesis in a mice model of subcutaneous melanoma cell transplantation, and explored the underlying mechanism. We found disruption of gu...

journal_title：Biochemical and biophysical research communications

authors： Xu C,Ruan B,Jiang Y,Xue T,Wang Z,Lu H,Wei M,Wang S,Ye Z,Zhai D,Wang L,Lu Z

更新日期：2017-06-24 00:00:00

abstract：:The product of the spontaneous dimerization and decarboxylation of aminoethylcysteine ketimine (simply named the dimer in this note) has been investigated for a possible biochemical activity. It has been found that the dimer inhibits the ADP-dependent oxidation of NAD(+)-linked substrates in rat liver mitochondria and...

journal_title：Biochemical and biophysical research communications

authors： Pecci L,Montefoschi G,Fontana M,Cavallini D

更新日期：1994-03-15 00:00:00

abstract：:GH3/B6 pituitary cells release prolactin (PRL) in response to thyrotropin releasing hormone (TRH). Electrophysiological assays of individual GH3 cells with sharp high-resistance microelectrodes have revealed complex effects of TRH on membrane excitability consisting of a transient hyperpolarization (1), which is thoug...

journal_title：Biochemical and biophysical research communications

authors： Dufy B,MacDermott A,Barker JL

更新日期：1986-05-29 00:00:00

abstract：:gamma-glutamyltranspeptidase (GGT) is a key enzyme implicated in the homeostasis of intracellular reduced glutathione (GSH) and hence in the regulation of the cellular redox state. Besides, the extracellular cleavage of GSH by GGT leads to reactive oxygen species (ROS) production, depending on the generation and enhan...

journal_title：Biochemical and biophysical research communications

authors： Accaoui MJ,Enoiu M,Mergny M,Masson C,Dominici S,Wellman M,Visvikis A

更新日期：2000-10-05 00:00:00

abstract：:A novel ribosome-inactivating protein designated beta-kirilowin was isolated from the seeds of Trichosanthes kirilowii. The proteins exhibited strong abortifacient activity in pregnant mice and produced a single band after SDS-polyacrylamide gel electrophoresis with an apparent mol. wt. of 27,500 daltons. It was activ...

journal_title：Biochemical and biophysical research communications

authors： Dong TX,Ng TB,Yeung HW,Wong RN

更新日期：1994-02-28 00:00:00

abstract：:The receptors for insulin and insulin-like growth factor (IGF)-I carry intrinsic tyrosine-specific protein kinases (TPK) in their cytoplasmic domains that show 84% homology. Our previous studies using tyrosine-containing synthetic polymers (Arch. Biochem. Biophys. 260, 416, 1988) revealed subtle differences between th...

journal_title：Biochemical and biophysical research communications

authors： Fujita-Yamaguchi Y,Kathuria S

更新日期：1988-12-30 00:00:00

abstract：:To develop antibodies against the plasma membrane 3,3',5-triiodo-L-thyronine (T3) binding protein (M.W. 55,000), rabbits were immunized with formalin-fixed GH3 cells or highly purified plasma membranes from these cells. Antibodies were screened by immunoprecipitation using detergent solubilized N-bromoacetyl-[125I]T3-...

journal_title：Biochemical and biophysical research communications

authors： Hasumura S,Rossi B,Alderson R,Pastan I,Cheng S

更新日期：1984-11-14 00:00:00

abstract：:Designed peptides that would selectively interact with lipopolysaccharide (LPS) or endotoxin and fold into specific conformations could serve as important scaffolds toward the development of antisepsis compounds. Here, we describe solution structure of a designed amphipathic peptide, H(2)N-YVKLWRMIKFIR-CONH(2) (YW12D)...

journal_title：Biochemical and biophysical research communications

authors： Bhunia A,Chua GL,Domadia PN,Warshakoon H,Cromer JR,David SA,Bhattacharjya S

更新日期：2008-05-09 00:00:00

abstract：:The bright bioluminescence of copepod Metridia longa is conditioned by a small secreted coelenterazine-dependent luciferase (MLuc). To date, three isoforms of MLuc differing in length, sequences, and some properties were cloned and successfully applied as high sensitive bioluminescent reporters. In this work, we repor...

journal_title：Biochemical and biophysical research communications

authors： Larionova MD,Markova SV,Vysotski ES

更新日期：2017-01-29 00:00:00

abstract：:Neuregulins comprise a group of growth factor proteins that regulate the differentiation of skeletal muscle. Here, we report that neuregulins are regulators of myogenic differentiation and stimulate mitogenesis in L6 skeletal myoblasts. The mitogenic response to neuregulin-1 was differentiation-dependent and observed ...

journal_title：Biochemical and biophysical research communications

authors： Ford BD,Han B,Fischbach GD

更新日期：2003-06-20 00:00:00

abstract：:The (45)Ca(2+) influx into right-side-out resealed ghosts (RG) prepared from human red blood cells (RBC) was measured. The (45)Ca(2+) equilibration occurred with t(1/2)=2.5 min and the steady-state was reached after 17 min with the level of 22+/-2 micromol/L(packed cells) at 37 degrees C. The rate of the influx was 97...

journal_title：Biochemical and biophysical research communications

authors： Hudec R,Lakatos B,Orlický J,Varecka L

更新日期：2004-12-24 00:00:00