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Novel inhibitors of advanced glycation endproducts.

Abstract：

:Enhanced formation and accumulation of advanced glycation endproducts (AGE's) have been proposed to play a major role in the pathogenesis of diabetic complications, aging, atherosclerosis, and Alzheimer disease leading to progressive and irreversible intermolecular protein crosslinkings. This process is accelerated in diabetes and has been postulated to contribute to the development of a range of diabetic complications including nephropathy, retinopathy and neuropathy. Several potential drug candidates as AGE inhibitors have been reported recently. Aminoguanidine is the first drug extensively studied both in vitro and in vivo. We have developed a new class of compounds as potent inhibitors of glycation and AGE formation. The novel inhibitors reported here are aryl (and heterocyclic) ureido, and aryl (and heterocyclic) carboxamido phenoxy isobutyric acids and related molecules, which were found by in vitro assay methods to be potent inhibitors of multiple stage of glycation and AGE formation.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Rahbar S,Kumar Yernini K,Scott S,Gonzales N,Lalezari I

doi

10.1006/bbrc.1999.1275

subject

Has Abstract

pub_date

1999-09-07 00:00:00

pages

651-6

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(99)91275-5

journal_volume

262

pub_type

杂志文章

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