Abstract:
:By immunohistochemistry it was found that PHI- and VIP-like immunoreactivity (-IR) occurred in the same autonomic neurons in the upper respiratory tract, tongue and salivary glands with associated ganglia in rat, guinea-pig, cat, pig and man. VIP- and PHI-like immunoreactivity was also found in similar locations in the human heart. The N-terminally directed, but not the C-terminally directed, PHI antiserum or the VIP antiserum stained endocrine cells in the pig duodenum. This suggests the existence of an additional PHI-like peptide. Ligation of nerves acutely caused marked overlapping axonal accumulations of PHI- and VIP-IR central to the lesion. Two weeks after transection of the nerves, both types of immunoreactivities were still observed in accumulations both in the axons as well as in the corresponding cell bodies. The levels of PHI- and VIP-IR in normal tissues from the cat were around 10-50 pmol/g with a molar ratio of about 1 to 2. Systemic administrations of PHI and VIP induced hypotension, probably due to peripheral vasodilation in both guinea-pig and cat. Furthermore, both PHI and VIP caused an inhibition of the vagally induced increase in respiratory insufflation pressure in guinea-pig. PHI and VIP relaxed the guinea-pig trachea in vitro, suggesting a direct action on tracheobronchial smooth muscle. VIP was about 5-10 times more potent than PHI with regard to hypotensive effects and 2-3-fold, considering respiratory smooth muscle-relaxant effects in the guinea-pig. PHI was about 50-fold less potent to induce hypotension in the cat than in the guinea-pig. Although species differences seem to exist as regards biological potency, PHI should also be considered when examining the role of VIP as an autonomic neurotransmitter.
journal_name
Peptidesjournal_title
Peptidesauthors
Lundberg JM,Fahrenkrug J,Hökfelt T,Martling CR,Larsson O,Tatemoto K,Anggård Adoi
10.1016/0196-9781(84)90090-1subject
Has Abstractpub_date
1984-05-01 00:00:00pages
593-606issue
3eissn
0196-9781issn
1873-5169pii
0196-9781(84)90090-1journal_volume
5pub_type
杂志文章相关文献
PEPTIDES文献大全abstract::Pituitary adenylate cyclase-activating polypeptide (PACAP) has a similar structure to that of vasoactive intestinal peptide (VIP) and both the polypeptides belong to the same molecular group, the secretin-glucagon superfamily. PACAP and VIP have possible potency as hypothalamic factors mediating the release of pituita...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2005.02.022
更新日期:2005-09-01 00:00:00
abstract::Previous studies have shown that the nervous system and other tissues of molluscs contain a number of peptides that potently excite molluscan hearts. Two such peptides, termed small cardioactive peptides A and B (SCPA and SCPB) are present in large quantities in the nervous system of Aplysia. These peptides are widely...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(87)90184-7
更新日期:1987-01-01 00:00:00
abstract::Trefoil factors family 2 (TFF2), also known as spasmolytic polypeptide, is primarily expressed in the mucus neck cells of gastrointestinal tracts. It has been proposed that TFF2 plays an important physiological role in protection, repair, and healing of gastrointestinal mucosa. To investigate the cis-acting regulatory...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2003.11.022
更新日期:2004-05-01 00:00:00
abstract::Previous physiological studies have suggested central roles of brain natriuretic peptide (BNP). However, little information is available about the localization of BNP in the brain. In this study, we determined cDNA sequence encoding the entire coding region of prepro-BNP of Japanese and cynomologus monkeys, and then e...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2006.01.001
更新日期:2006-07-01 00:00:00
abstract::The effects of atrial natriuretic factor (ANF) on [3H]norepinephrine ([3H]NE) release evoked by a sodium-free medium (SFM) were studied. Experiments were performed in rat adrenal medulla slices incubated in vitro. Results showed that [3H]NE release evoked by the omission of Na+ was decreased by 10 nM ANF. In addition,...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(94)90100-7
更新日期:1994-01-01 00:00:00
abstract::Circulating urotensin II (UII) concentrations and the tissue expression of its cognate receptor (UT) are elevated in patients with cardiovascular disease (CVD). The functional significance of elevated plasma UII levels in CVD is unclear. Urotensin-related peptide (URP) is a paralog of UII in that it contains the six a...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2007.08.013
更新日期:2008-05-01 00:00:00
abstract::Many scorpion toxins that act on sodium channels (NaScTxs) have been characterized till date. These toxins may act modulating the inactivation or the activation of sodium channels and are named α- or β-types, respectively. Some venom toxins from Tityus obscurus (Buthidae), a scorpion widely distributed in the Brazilia...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2017.07.010
更新日期:2017-09-01 00:00:00
abstract::Cationic lytic-type peptides have been studied for clinical application in various infections and cancers. This study aimed to determine the functions of our specially designed lytic peptide. To investigate the functional mechanism at the cell membrane level, we used giant unilayer vesicles (GUVs) mimicking cell membr...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2013.09.015
更新日期:2013-12-01 00:00:00
abstract::In this study, an amphibian (Odorrana hejiangensis) skin extract was fractionated by reverse phase HPLC and fractions were screened for trypsin inhibitory activity. Using this initial approach, a novel trypsin inhibitory peptide was detected with an apparent protonated molecular mass of 1804.83 Da, as determined by MA...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2012.01.003
更新日期:2012-02-01 00:00:00
abstract::We have developed a radioimmunoassay for synthetic dynorphin B, a novel opioid tridecapeptide, which shares a common precursor molecule with dynorphin1-17 (= dynorphin A) and the neo-endorphins. The levels of immunoreactivity towards this peptide in rat brain and pituitary show a pattern quantitatively and qualitative...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(83)90083-9
更新日期:1983-11-01 00:00:00
abstract::PACAP-27 and PACAP-38 are the exclusive physiological ligands for the mammalian PAC1 receptor. The role of C-terminal amidation of these ligands at that receptor was examined in neuroendocrine cells expressing the PAC1 receptor endogenously and in non-neuroendocrine cells in which the human and rat PAC1 receptors were...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2016.03.003
更新日期:2016-05-01 00:00:00
abstract::Bombyxin-IV, a molecular species of bombyxin, which is a member of insulin-like heterodimeric peptides of the silkworm Bombyx mori with prothoracicotropic hormone activity, was synthesized. The A- and B-chains of bombyxin-IV containing four and two Cys residues, respectively, were first synthesized separately by solid...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(90)90126-p
更新日期:1990-01-01 00:00:00
abstract::The elevated T-maze was combined with a free exploration protocol, which, in contrast to the conventional procedure, dispenses with handling of the animals during the experimental sessions. This allows measurement of fear indexes derived from the elevated plus-maze as well as assessment of acquisition of open arm avoi...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(01)00421-1
更新日期:2001-07-01 00:00:00
abstract::The purpose of this study was to investigate in the aged animal the functional interaction between cholecystokinin (CCK) and amino acid neurotransmitter activity in the frontal cortex, a structure of importance in age-related disabilities. Guide cannula for repeated push-pull perfusion were implanted bilaterally in th...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(88)90175-1
更新日期:1988-05-01 00:00:00
abstract::To identify a minimal peptide ligand that participates in recognition of heparin, we synthesized peptides extending a 29-kDa fragment in the C-terminal heparin binding domain of fibronectin. We obtained evidence that two peptides (designated D5 and D1) exhibit inhibitory activity on binding of the 29-kDa fragment to h...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(96)00149-0
更新日期:1996-01-01 00:00:00
abstract::We have previously reported that hypoxia activates corticotrophin-releasing hormone (CRH) and the expression of its type-1 receptor (CRHR1) and induces disorders of the brain-endocrine-immune network. p53 is activated by hypoxia and involved in tumorigenesis and apoptosis. Whether CRHR1 regulates p53 transactivation t...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2013.03.023
更新日期:2013-06-01 00:00:00
abstract::Dissociated neurointermediate lobe cells (75%) bound [biotinyl-Ser1]corticotropin releasing hormone (bio-CRH) and secreted adrenocorticotropin [ACTH(25-39)] in a reverse hemolytic plaque assay (RHPA). The bio-CRH was rapidly internalized (less than 1 min) in vesicles and scattered vacuoles. Plaque percentages increase...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(90)90188-b
更新日期:1990-07-01 00:00:00
abstract::The basal caeliferan family Tetrigidae is investigated to identify neuropeptides belonging to the adipokinetic hormone (AKH) family. The pygmy grasshopper Tetrix subulata contains in its corpus cardiacum two octapeptides as revealed by liquid chromatography coupled to electrospray ionization mass spectrometry. The les...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2015.01.008
更新日期:2015-06-01 00:00:00
abstract::BMAP-27, a member of cathelicidin family, plays an important role against microorganisms, including bacteria and fungi. BMAP-27 may exert antimicrobial effects through membrane integrity disruption, but the exact molecular mechanism remains unclear. To identify the structural features important for antimicrobial activ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2019.170106
更新日期:2019-08-01 00:00:00
abstract::As a novel vasoactive peptide, plasma coupling factor 6 (CF6) was shown to be elevated in patients with diabetes mellitus, yet the mechanism involved is unknown. We studied CF6 protein release and its potential mechanism in human umbilical vein endothelial cells (HUVECs) incubated with high glucose levels. High glucos...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2006.11.006
更新日期:2007-03-01 00:00:00
abstract::Experiments characterized the behavioral effects of bombesin (BN) administered systemically (1-8 micrograms/kg; IP) or centrally at the nucleus tractus solitarius (NTS) and the nucleus accumbens (NA) (0.0001-1.0 microgram/0.5 microliter). The role of dopaminergic system(s) in the mediation of BN-induced behavioral eff...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(88)90249-5
更新日期:1988-01-01 00:00:00
abstract::The UII and urotensin II-related peptide (URP) genes belong to the same superfamily as the somatostatin gene. It has been previously shown that somatostatin activates the UII-receptor (UTR). In contrast, the possible interaction between UII and URP and somatostatin receptors has remained scarcely analyzed. Herein, we ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2007.12.015
更新日期:2008-05-01 00:00:00
abstract::Pharmacological study of Phe-Met-Leu-Phe-amide (FMRFa) receptors is hindered by the lack of selective ligands. The classification of these selective ligands is further hampered by the limited availability of functional assays. In this study, we evaluated several synthetic FMRFa analogs for agonist and antagonist activ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(97)00481-6
更新日期:1998-01-01 00:00:00
abstract::Although a great deal is published on the MCH neurons, very few works were devoted to the study of their development. However, existing literature points out two important traits: first, these neurons differentiate a MCH phenotype very early in all species studied so far, which might suggest a role for the MCH peptide...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/j.peptides.2009.07.016
更新日期:2009-11-01 00:00:00
abstract::Higher plasma copeptin level has been associated with poor outcomes of critical illness. The present study was undertaken to investigate the plasma copeptin concentrations in children with traumatic brain injury (TBI) and to analyze the correlation of copeptin with disease outcome. Plasma copeptin concentrations of 12...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2013.01.015
更新日期:2013-04-01 00:00:00
abstract::Studies on the in vitro interaction of beta-endorphin with different biomembrane preparations, measured in terms of Ca2+ induced chlorotetracycline (CTC) fluorescence alterations indicate that beta-endorphin causes release of calcium ion from both synaptosomal and erythrocyte membrane stores but not from rat brain mit...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(83)90131-6
更新日期:1983-05-01 00:00:00
abstract::In the rat small intestine, neurotrophin-3 immunoreactivity was identified in ganglion cells and in processes mostly innervating the mucosa and occasionally the muscle layer and vasculature. The vast majority of neurotrophin-3 immunoreactive neurons contained vasoactive intestinal polypeptide (VIP), but not substance ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(00)00286-2
更新日期:2000-09-01 00:00:00
abstract::Peptides of the short neuropeptide F (sNPF) family have been shown to modulate feeding behavior in a wide variety of insect species. While these peptides stimulate feeding and food-searching behavior in Drosophila melanogaster and Apis mellifera, an opposite effect has recently been demonstrated in the desert locust, ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2013.09.018
更新日期:2014-03-01 00:00:00
abstract::Defensins are essentially ancient natural antibiotics with potent activity extending from lower organisms to humans. They can inhibit the growth or virulence of micro-organisms directly or indirectly enhance the host's immune system. The successful prediction of defensin peptides will provide very useful information a...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2009.06.032
更新日期:2009-10-01 00:00:00
abstract::Intestinal levels of immunoreactive neurotensin (iNT) and neuromedin N (iNMN), as well as mRNA for the NT/NMN precursor, were elevated during the suckling period in rats. While transient expression of NT/NMN was observed at 1-5 days of age in the proximal small intestine and colon, NT/NMN levels in the ileum increased...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(93)90161-9
更新日期:1993-11-01 00:00:00