Abstract:
:To identify a minimal peptide ligand that participates in recognition of heparin, we synthesized peptides extending a 29-kDa fragment in the C-terminal heparin binding domain of fibronectin. We obtained evidence that two peptides (designated D5 and D1) exhibit inhibitory activity on binding of the 29-kDa fragment to heparin-Sepharose CL 6B. It dose inhibitory studies, peptide D5 showed the potent inhibitory activity with IC50 of 210 +/- 37 microM. A new heparin binding site in the C-terminal heparin binding domain of fibronectin is demonstrated and provides a rationale for understanding the mechanism of cell adhesion and spreading.
journal_name
Peptidesjournal_title
Peptidesauthors
Mohri H,Katoh K,Motomura S,Okubo Tdoi
10.1016/0196-9781(96)00149-0subject
Has Abstractpub_date
1996-01-01 00:00:00pages
1079-81issue
6eissn
0196-9781issn
1873-5169pii
0196-9781(96)00149-0journal_volume
17pub_type
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