Novel synthetic peptides from the C-terminal heparin binding domain of fibronectin with heparin binding activity.

Abstract:

:To identify a minimal peptide ligand that participates in recognition of heparin, we synthesized peptides extending a 29-kDa fragment in the C-terminal heparin binding domain of fibronectin. We obtained evidence that two peptides (designated D5 and D1) exhibit inhibitory activity on binding of the 29-kDa fragment to heparin-Sepharose CL 6B. It dose inhibitory studies, peptide D5 showed the potent inhibitory activity with IC50 of 210 +/- 37 microM. A new heparin binding site in the C-terminal heparin binding domain of fibronectin is demonstrated and provides a rationale for understanding the mechanism of cell adhesion and spreading.

journal_name

Peptides

journal_title

Peptides

authors

Mohri H,Katoh K,Motomura S,Okubo T

doi

10.1016/0196-9781(96)00149-0

subject

Has Abstract

pub_date

1996-01-01 00:00:00

pages

1079-81

issue

6

eissn

0196-9781

issn

1873-5169

pii

0196-9781(96)00149-0

journal_volume

17

pub_type

杂志文章

相关文献

PEPTIDES文献大全
  • Oxytocin, oxytocin antagonist, TRH, and hypothalamic paraventricular nucleus stimulation effects on gastric motility.

    abstract::The roles of thyrotropin releasing hormone (TRH) and oxytocin as central regulators of gastric motility were investigated. Picomolar (4 picomoles) quantities of TRH injected into the dorsal motor nucleus of the vagus (DMN) elicited a significant increase in gastric motility while the same quantity of oxytocin elicited...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/0196-9781(87)90017-9

    authors: Rogers RC,Hermann GE

    更新日期:1987-05-01 00:00:00

  • Cellular colocalization of diuretic peptides in locusts: a potent control mechanism.

    abstract::Locust abdominal ganglia are shown to colocalize Locusta-diuretic peptide-, leucokinin I-, and lysine vasopressin-like immunoreactivity in posterior lateral neurosecretory cells. Extracts of abdominal ganglia were partially purified by RP-HPLC then dot immunoassay screened with the same antisera used for immunocytoche...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/0196-9781(94)00158-3

    authors: Thompson KS,Rayne RC,Gibbon CR,May ST,Patel M,Coast GM,Bacon JP

    更新日期:1995-01-01 00:00:00

  • Glycopeptide drugs: A pharmacological dimension between "Small Molecules" and "Biologics".

    abstract::Peptides are an important class of molecules with diverse biological activities. Many endogenous peptides, especially neuropeptides and peptide hormones, play critical roles in development and regulating homeostasis. Furthermore, as drug candidates their high receptor selectivity and potent binding leads to reduced of...

    journal_title:Peptides

    pub_type: 杂志文章,评审

    doi:10.1016/j.peptides.2020.170369

    authors: Apostol CR,Hay M,Polt R

    更新日期:2020-09-01 00:00:00

  • Beta-endorphin- and GABA-mediated depressor effect of specific electroacupuncture surpasses pressor response of emotional circuit.

    abstract::It has been proved that input of specific electroacupuncture (EA) can activate beta-endorphin(beta-EP)ergic and noradrenergic neurons projecting to the rostral ventrolateral medulla (RVL), the latter acting upon the RVL-GABAergic interneurons, thereby produce depressor effect. The present study further shows that: (1)...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/s0196-9781(01)00467-3

    authors: Ku YH,Chang YZ

    更新日期:2001-09-01 00:00:00

  • LmrBPP9: A synthetic bradykinin-potentiating peptide from Lachesis muta rhombeata venom that inhibits the angiotensin-converting enzyme activity in vitro and reduces the blood pressure of hypertensive rats.

    abstract::Bradykinin-potentiating peptides (BPPs) are an important group of toxins present in Lachesis muta rhombeata venom. They act directly at renin-angiotensin-aldosterone system, through the inhibition of angiotensin-converting enzyme (ACE). This action may contribute to the hypotensive shock observed during the envenoming...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/j.peptides.2018.01.015

    authors: Pinheiro-Júnior EL,Boldrini-França J,de Campos Araújo LMP,Santos-Filho NA,Bendhack LM,Cilli EM,Arantes EC

    更新日期:2018-04-01 00:00:00

  • Identification of the short neuropeptide F precursor in the desert locust: evidence for an inhibitory role of sNPF in the control of feeding.

    abstract::Peptides of the short neuropeptide F (sNPF) family have been shown to modulate feeding behavior in a wide variety of insect species. While these peptides stimulate feeding and food-searching behavior in Drosophila melanogaster and Apis mellifera, an opposite effect has recently been demonstrated in the desert locust, ...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/j.peptides.2013.09.018

    authors: Dillen S,Verdonck R,Zels S,Van Wielendaele P,Vanden Broeck J

    更新日期:2014-03-01 00:00:00

  • Quantitative and qualitative effects of ethanol on the LHRH-LH axis of the rat.

    abstract::Ethanol (ETOH) has been shown to have pronounced effects on reproductive endocrinology in humans as well as laboratory animals. We have studied the effects of ETOH on the hypothalamic-pituitary-luteinizing hormone (LH) axis, using the male rat as an animal model. In order to better understand the method by which ETOH ...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/0196-9781(84)90278-x

    authors: Dees WL,Kozlowski GP

    更新日期:1984-01-01 00:00:00

  • Purification and characterization of a novel antimicrobial peptide from Brevibacillus laterosporus strain A60.

    abstract::A novel antimicrobial peptide, with molecular mass of 1602.0469Da, produced by Brevibacillus laterosporus strain A60 was isolated and purified from the soil of mango plants. The purification procedure consisted of ammonium sulfate precipitation, cation exchange chromatography on an HiTrap SP HP column, thin layer chro...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/j.peptides.2012.01.001

    authors: Zhao J,Guo L,Zeng H,Yang X,Yuan J,Shi H,Xiong Y,Chen M,Han L,Qiu D

    更新日期:2012-02-01 00:00:00

  • Inhibitory effect of ceruletide on haloperidol-induced catalepsy in rats.

    abstract::Ceruletide (CLT: 160 micrograms/kg, SC) produced a relatively long-lasting inhibition of haloperidol (HPD: 2 mg/kg, PO) catalepsy in rats. Neither bilateral vagotomies nor hypophysectomy abolished the anticataleptic effect of CLT. However, (-)-L-364,718 and proglumide blocked the effect of CLT. CLT (160 micrograms/kg)...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/0196-9781(89)90113-7

    authors: Ibii N,Ikeda M,Takahara Y,Eigyo M,Akiyoshi T,Matsushita A

    更新日期:1989-07-01 00:00:00

  • Membrane active antimicrobial activity and molecular dynamics study of a novel cationic antimicrobial peptide polybia-MPI, from the venom of Polybia paulista.

    abstract::As the frequent emergence of the resistant bacteria, the development of new agents with a new action mode attracts a great deal of interest. It is now widely accepted that antimicrobial peptides (AMPs) are promising alternatives to conventional antibiotics. In this study, antimicrobial peptide polybia-MPI and its anal...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/j.peptides.2012.11.002

    authors: Wang K,Yan J,Dang W,Liu X,Chen R,Zhang J,Zhang B,Zhang W,Kai M,Yan W,Yang Z,Xie J,Wang R

    更新日期:2013-01-01 00:00:00

  • Roles of different peptide fragments derived from proadrenomedullin in the regulation of vascular tone in isolated rat aorta.

    abstract::The effects of proadrenomedullin N-terminal 20 peptide (PAMP) and adrenotensin (ADT) on adrenomedullin (ADM)-induced vasodilation were investigated in aortic rings from rat. ADM (10(-9) to 10(-7)M) relaxed the aorta preconstricted with phenylephrine in a concentration-dependent manner. Denudation of endothelium or pre...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/s0196-9781(03)00109-8

    authors: Li J,Ren Y,Dong X,Zhong G,Wu S,Tang C

    更新日期:2003-04-01 00:00:00

  • MIF-I suppresses deprivation-induced fluid consumption in rats.

    abstract::Rats were injected IP with a 0.1 mg/kg dose of MIF-I, naloxone, dynorphin, [D-Phe4]-Met-enkephalin, [D-Ala2, F5Phe4]-Met-enkephalin-NH2, or the diluent vehicle, placed in their home cages for ten minutes, and then given ad lib access to either 20% sucrose, 10% sucrose, water, 0.01% quinine, or 0.02% quinine in a repea...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/0196-9781(80)90014-5

    authors: Olson RD,Kastin AJ,Olson GA,King BM,Von Almen TK,Berzas MC,Ibanez ML,Coy DH

    更新日期:1980-01-01 00:00:00

  • A novel VIP signaling pathway in T cells cAMP-->protein tyrosine phosphatase (SHP-2?)-->JAK2/STAT4-->Th1 differentiation.

    abstract::Vasoactive intestinal peptide (VIP) is a potent anti-inflammatory agent. In addition to the deactivation of macrophages, dendritic cells, and microglia, VIP shifts the Th1/Th2 balance, promoting the preferential differentiation and survival of Th2 cells, to the detriment of the proinflammatory Th1 effectors. Several m...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/j.peptides.2007.03.015

    authors: Liu L,Yen JH,Ganea D

    更新日期:2007-09-01 00:00:00

  • Intracerebroventricular administration of neuronostatin delays gastric emptying and gastrointestinal transit in mice.

    abstract::Neuronostatin is a 13-amino acid amidated peptide widely distributed in various organs including gastrointestinal tract. However, the effect of neuronostatin on gastrointestinal motility has not been well characterized. In the present work, effects of central administration of neuronostatin on gastric emptying and gas...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/j.peptides.2012.03.013

    authors: Su SF,Yang AM,Yang SB,Wang NB,Lu SS,Wang HH,Chen Q

    更新日期:2012-05-01 00:00:00

  • Change in substance P in a firearm wound and its significance.

    abstract::The present study was designed to detect the change of substance P (SP) in firearm wounds and its relationship with wound healing. Twenty two rabbits were randomly divided into two groups, one with firearm wounds created by steel balls shooting rabbits' thighs and another with stab wounds created by knife. The experim...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/s0196-9781(98)00068-0

    authors: Xinan L,Suguang L,Liangchao Z,Lei C

    更新日期:1998-01-01 00:00:00

  • The AT2 receptor--a matter of love and hate.

    abstract::In 1989, the development of specific angiotensin receptor antagonists which distinguish between two angiotensin receptor subtypes (AT1 and AT2) led to a breakthrough in angiotensin research. It turned out, that the AT1 receptor was almost entirely responsible for the "classical" actions of angiotensin II related to th...

    journal_title:Peptides

    pub_type: 杂志文章,评审

    doi:10.1016/j.peptides.2005.03.010

    authors: Steckelings UM,Kaschina E,Unger T

    更新日期:2005-08-01 00:00:00

  • B-type natriuretic peptide in outpatients after myocardial infarction: optimized cut-off value for incident heart failure prediction.

    abstract::Higher levels of natriuretic peptides were identified in outpatients after myocardial infarction (MI) compared to the healthy population, even in the absence of heart failure (HF). Therefore, we assessed the optimal cut-off value of B-type natriuretic peptide (BNP) in relation to new-onset HF prediction in 79 post-MI ...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/j.peptides.2010.06.023

    authors: Radovanovic M,Vasiljevic Z,Radovanovic N,Marinkovic J,Beleslin B,Mitrovic P,Stankovic S,Stankovic G

    更新日期:2010-10-01 00:00:00

  • Non-associative learning and anxiety in rats treated with a single systemic administration of the gastrin-releasing peptide receptor antagonist RC-3095.

    abstract::The gastrin-releasing peptide receptor (GRPR) has been implicated in the modulation of emotionally-motivated memory. In the present study, we investigated the role of the GRPR on non-emotional, non-associative memory, and anxiety. Adult male Wistar rats were given a systemic injection of the GRPR antagonist [D-Tpi6, L...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/j.peptides.2005.06.006

    authors: Martins MR,Reinke A,Valvassori SS,Machado RA,Quevedo J,Schwartsmann G,Roesler R

    更新日期:2005-12-01 00:00:00

  • Opposite effects of intraventricular and intracisternal administration of vasopressin on blood pressure in rats.

    abstract::Lysine-8-vasopressin (LVP) was injected into the lateral ventricle (ICV) or into the cisterna magna (c.m.) of ether-anesthetized rats. ICV injection of LVP decreased the blood pressure (BP), whereas c.m. administration increased it. The opposite effects of ICV versus c.m. administration of the peptide might be related...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/0196-9781(86)90021-5

    authors: Günther O,Kovács GL,Szabó G,Telegdy G

    更新日期:1986-05-01 00:00:00

  • C-terminal amide to alcohol conversion changes the cardiovascular effects of endomorphins in anesthetized rats.

    abstract::Endomorphin1-ol (Tyr-Pro-Trp-Phe-ol, EM1-ol) and endomorphin2-ol (Tyr-Pro-Phe-Phe-ol, EM2-ol), with C-terminal alcohol (-ol) containing, have been shown to exhibit higher affinity and lower intrinsic efficacy in vitro than endomorphins. In the present study, in order to investigate the alterations of systemic hemodyna...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/j.peptides.2005.07.006

    authors: Yu Y,Wang CL,Cui Y,Fan YZ,Liu J,Shao X,Liu HM,Wang R

    更新日期:2006-01-01 00:00:00

  • Angiotensin II reduces serotonin release in the rat subfornical organ area.

    abstract::In the present study we used intracerebral microdialysis techniques to examine whether angiotensin II (ANG II) modulates the release of serotonin (5-hydroxytryptamine, 5-HT) in the subfornical organ (SFO) in freely moving rats. Extracellular concentrations of 5-HT and its metabolite 5-hydroxyindoleacetic acid (5-HIAA)...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/s0196-9781(03)00164-5

    authors: Tanaka J,Kariya K,Nomura M

    更新日期:2003-06-01 00:00:00

  • Impaired retention by angiotensin II mediated by the AT1 receptor.

    abstract::We demonstrated previously that hippocampal dentate gyrus neurons were sensitive to angiotensin II (AII) and recently discovered that AII applied directly to the dentate gyrus inhibited granule cell long-term potentiation induction and that the inhibition is mediated by the AT1 receptor and can be blocked by losartan,...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/0196-9781(95)00073-s

    authors: Lee EH,Ma YL,Wayner MJ,Armstrong DL

    更新日期:1995-01-01 00:00:00

  • An update on the role of irisin in the regulation of endocrine and metabolic functions.

    abstract::Irisin is a novel myokine and adipokine that has gained much attention recently due to its mechanisms of action. Irisin is secreted following proteolytic cleavage of its precursor fibronectin type III domain containing 5 (FNDC5). Following its release, irisin exerts its major action by increasing the expression of mit...

    journal_title:Peptides

    pub_type: 杂志文章,评审

    doi:10.1016/j.peptides.2018.03.018

    authors: Mahgoub MO,D'Souza C,Al Darmaki RSMH,Baniyas MMYH,Adeghate E

    更新日期:2018-06-01 00:00:00

  • Pharmacological characterization of angiotensin II binding sites in the canine pancreas.

    abstract::High affinity 125I-angiotensin II (Ang II) binding sites were characterized in the canine pancreas. Total binding increased with protein concentration and equilibrium was reached within 60-90 min at 22 degrees C. Specific binding was saturable and averaged 70% of total. Scatchard analysis of binding yielded a KD of 0....

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/0196-9781(92)90114-i

    authors: Chappell MC,Diz DI,Jacobsen DW

    更新日期:1992-03-01 00:00:00

  • The state versus amyloid-beta: the trial of the most wanted criminal in Alzheimer disease.

    abstract::Investigators studying the primary culprit responsible for Alzheimer disease have, for the past two decades, primarily focused on amyloid-beta (Abeta). Here, we put Abeta on trial and review evidence amassed by the prosecution that implicate Abeta and also consider arguments and evidence gathered by the defense team w...

    journal_title:Peptides

    pub_type: 杂志文章,评审

    doi:10.1016/s0196-9781(02)00069-4

    authors: Rottkamp CA,Atwood CS,Joseph JA,Nunomura A,Perry G,Smith MA

    更新日期:2002-07-01 00:00:00

  • Peptidomic analysis of blood plasma after in vivo treatment with protease inhibitors--a proof of concept study.

    abstract::Native peptides can be regarded as surrogate markers for protease activity in biological samples. Analysis of peptides by peptidomics allows to monitor protease activity in vivo and to describe the influence of protease inhibition. To elucidate the potential of peptides as markers for in vivo protease inhibition we an...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/j.peptides.2008.08.016

    authors: Tammen H,Hess R,Rose H,Wienen W,Jost M

    更新日期:2008-12-01 00:00:00

  • Production of VIP- and PHM (human PHI)-related peptides in human neuroblastoma cells.

    abstract::We demonstrated the production and release of a peptide structurally identical with porcine and bovine VIP-28 in human neuroblastoma NB-OK-1 cell line. In the cells, VIP-like immunoreactive (IR-VIP) components of 8 K dalton (Kd), 11 Kd, 18 Kd and 30 Kd were also detected and the 8 Kd and 18 Kd components were apparent...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/0196-9781(84)90199-2

    authors: Hoshino M,Yanaihara C,Ogino K,Iguchi K,Sato H,Suzuki T,Yanaihara N

    更新日期:1984-03-01 00:00:00

  • Plantaricin A synthesized by Lactobacillus plantarum induces in vitro proliferation and migration of human keratinocytes and increases the expression of TGF-β1, FGF7, VEGF-A and IL-8 genes.

    abstract::This work showed the effect of pheromone plantaricin A (PlnA) on the proliferation and migration of the human keratinocytes NCTC 2544. PlnA was chemically synthesized and used as pure peptide or biologically synthesized during co-cultivation of Lactobacillus plantarum DC400 and Lactobacillus sanfranciscensis DPPMA174....

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/j.peptides.2011.07.004

    authors: Pinto D,Marzani B,Minervini F,Calasso M,Giuliani G,Gobbetti M,De Angelis M

    更新日期:2011-09-01 00:00:00

  • Increased serum chemerin level promotes cellular invasiveness in gastric cancer: a clinical and experimental study.

    abstract::This study sought to determine the serum levels of chemerin in gastric cancer patients and healthy subjects and to investigate the biological effect of chemerin on gastric cancer cells. Serum chemerin level of 36 gastric cancer patients and 40 healthy subjects was measured by enzyme-linked immunosorbent assay. AGS and...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/j.peptides.2013.10.009

    authors: Wang C,Wu WK,Liu X,To KF,Chen GG,Yu J,Ng EK

    更新日期:2014-01-01 00:00:00

  • Vasoactive intestinal peptide increases VEGF expression to promote proliferation of brain vascular endothelial cells via the cAMP/PKA pathway after ischemic insult in vitro.

    abstract::Vasoactive intestinal peptide (VIP) enhances angiogenesis in rats with focal cerebral ischemia. In the present study, we investigated the molecular mechanism of the proangiogenic action of VIP using an in vitro ischemic model, in which rat brain microvascular endothelial cells (RBMECs) are subjected to oxygen and gluc...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/j.peptides.2013.01.007

    authors: Yang J,Shi QD,Song TB,Feng GF,Zang WJ,Zong CH,Chang L

    更新日期:2013-04-01 00:00:00