Abstract：
:Experiments characterized the behavioral effects of bombesin (BN) administered systemically (1-8 micrograms/kg; IP) or centrally at the nucleus tractus solitarius (NTS) and the nucleus accumbens (NA) (0.0001-1.0 microgram/0.5 microliter). The role of dopaminergic system(s) in the mediation of BN-induced behavioral effects in rats was also investigated. In the "satiety" paradigm, grooming and eating behaviors were monitored in 5-hr-food-deprived rats trained to take a portion of their daily food intake over the 20 min observation period. The elicitation of grooming and satiety appeared to be specific to BN administration at the NTS but not the NA. The dopaminergic system(s) did not appear to mediate the behavior effects of BN intra NTS. The BN-induced grooming profile appeared to be paradigm independent although the baseline grooming profile was not. At the NTS, a dissociation of BN-induced grooming and satiety was evident on the basis of time-course and dose-effect. The similarity of the time-course of satiety induced by BN injected at the NTS and IP suggested that BN may mediate a physiological satiety signal at the NTS. Furthermore, since BN induced satiety 10(4) more potently and 20% more efficaciously intra NTS than IP, the NTS may be a critical site for the action of BN on satiety.
journal_name
Peptidesjournal_title
Peptidesauthors
Johnston SA,Merali Zdoi
10.1016/0196-9781(88)90249-5subject
Has Abstractpub_date
1988-01-01 00:00:00pages
233-44eissn
0196-9781issn
1873-5169pii
0196-9781(88)90249-5journal_volume
9 Suppl 1pub_type
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